Patents by Inventor Andreas Kuhn
Andreas Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240110214Abstract: The present disclosure provides technologies for performing in vitro transcription that can generate product RNA preparations with reduced levels of certain contaminants (e.g., aberrant products), and particularly of double-stranded RNA (dsRNA).Type: ApplicationFiled: December 7, 2021Publication date: April 4, 2024Inventors: Thomas Ziegenhals, Andreas Kuhn, Stephanie Fesser
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Publication number: 20240101999Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).Type: ApplicationFiled: August 17, 2023Publication date: March 28, 2024Inventors: Thomas POEHMERER, Phillip KUHN, Frank NOTKA, Andreas ZEIDLER, Korbinian HEIL, Axel TREFZER, Geir FONNUM, Federico KATZEN, Kristian ANDERSSON, Xiquan LIANG
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Patent number: 11925694Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject. i.e., vaccine RNA encoding vaccine antigen.Type: GrantFiled: March 18, 2022Date of Patent: March 12, 2024Assignee: BioNTech SEInventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Publication number: 20240075165Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.Type: ApplicationFiled: November 16, 2022Publication date: March 7, 2024Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Patent number: 11916465Abstract: A compensating element having a first and a second assembly, wherein a locking mechanism is provided which can be switched over between a first and a second operating state. In the first operating state, the first assembly is connected fixedly to the second assembly and, in the second operating state, the first and second assemblies are connected to each other via a spring mechanism in such a manner that they are movable relative to each other. The locking mechanism includes an electric motor that can be used to switch over between the first and the second operating state. A locking ring is or is not braced against at least three balls depending on its rotational position with respect to a center axis. The locking ring is connected in terms of rotary drive to the electric motor via a torsion spring which is elastic with respect to the center axis.Type: GrantFiled: June 23, 2022Date of Patent: February 27, 2024Assignee: Robert Bosch GmbHInventors: Michael Danzberger, Andreas Rueb, Christoph Janssen, Efim Kuhn, Fan Yang, Markus Groganz, Peter Schlegel, Sebastian Siedler, Thomas Dickmann
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Publication number: 20240002127Abstract: The present disclosure relates to the fields of packaging, transportation, and storage of temperature-sensitive materials, such as biological and/or pharmaceutical products. Various aspects of such packaging, transportation, and storage are provided herein for ultra-low temperature materials useful for the treatment and/or prevention of disease. The present disclosure also provides packaging materials, methods of transportation, and methods of storage for maintaining biological and/or pharmaceutical materials at ultra-low temperatures in order to maintain the integrity of the materials. The present disclosure further relates to the field of RNA to prevent or treat coronavirus infection.Type: ApplicationFiled: April 16, 2021Publication date: January 4, 2024Inventors: Marjoh Nauta, Dirk Jozef Peeters, Tom Frank Steven Van Doorslaer, Advait Vijay Badkar, Ramin Darvari, Nicholas William Warne, James Jean, Danny Pierre G. Hendrikse, Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Publication number: 20230312348Abstract: A process for preparing a porous carbon material. The process comprises the process steps: providing a carbon source; providing an amphiphilic species; contacting the carbon source and the amphiphilic species to obtain a precursor; and heating the precursor to obtain the porous carbon material; wherein the carbon source comprises a carbon source compound, wherein the carbon source compound comprises an aromatic ring having one or more attached OH groups and an ester link.Type: ApplicationFiled: April 21, 2023Publication date: October 5, 2023Inventors: Julie MICHAUD-BERNLOCHNER, Daniel WEINGARTH, Andreas KUHN, Dominik SAMUELIS
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Publication number: 20230312349Abstract: A process for the preparation of a porous carbon material using an improved amphiphilic species. Also disclosed are a porous carbon material, devices comprising the porous carbon material and use of an amphiphilic compound for the preparation of a porous carbon material. The process for preparing a porous carbon material comprises the process steps: (a) providing a carbon source comprising a first carbon source compound; (b) providing an amphiphilic species comprising a first amphiphilic compound, the first amphiphilic compound comprising two or more adjacent ethylene oxide-based repeating units; (c) contacting the carbon source and the amphiphilic species to obtain a precursor; and (d) heating the precursor to obtain the porous carbon material.Type: ApplicationFiled: June 7, 2023Publication date: October 5, 2023Inventors: Julie MICHAUD-BERNLOCHNER, Daniel WEINGARTH, Andreas KUHN, Dominik SAMUELIS
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Patent number: 11746015Abstract: A process for the preparation of a porous carbon material using an improved amphiphilic species. Also disclosed are a porous carbon material, devices comprising the porous carbon material and use of an amphiphilic compound for the preparation of a porous carbon material. The process for preparing a porous carbon material comprises the process steps: (a) providing a carbon source comprising a first carbon source compound; (b) providing an amphiphilic species comprising a first amphiphilic compound, the first amphiphilic compound comprising two or more adjacent ethylene oxide-based repeating units; (c) contacting the carbon source and the amphiphilic species to obtain a precursor; and (d) heating the precursor to obtain the porous carbon material.Type: GrantFiled: October 26, 2018Date of Patent: September 5, 2023Assignee: HERAEUS BATTERY TECHNOLOGY GMBHInventors: Julie Michaud-Bernlochner, Daniel Weingarth, Andreas Kuhn, Dominik Samuelis
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Publication number: 20230272406Abstract: The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3?-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.Type: ApplicationFiled: September 28, 2022Publication date: August 31, 2023Inventors: Alexandra Orlandini Von Niessen, Stephanie Fesser, Britta Vallazza, Tim Beissert, Andreas Kuhn, Ugur Sahin, Marco Alexander Poleganov
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Publication number: 20230183769Abstract: The present disclosure provides technologies for in vitro transcription reactions, particularly for production of pharmaceutical grade RNA, and in some embodiments for large scale production.Type: ApplicationFiled: August 23, 2022Publication date: June 15, 2023Inventors: Irena Rabe, Maximilian Buff, Thomas Ziegenhals, Johanna Drögemüller, Andreas Kuhn, Stephanie Fesser, Rodney Gene Combs, Nicole Eschmann, Jennifer Ann Schoborg Romine, Jenna Kathryn Williamson
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Patent number: 11661343Abstract: A process for preparing a porous carbon material. The process comprises the process steps: providing a carbon source; providing an amphiphilic species; contacting the carbon source and the amphiphilic species to obtain a precursor; and heating the precursor to obtain the porous carbon material; wherein the carbon source comprises a carbon source compound, wherein the carbon source compound comprises an aromatic ring having one or more attached OH groups and an ester link.Type: GrantFiled: October 26, 2018Date of Patent: May 30, 2023Assignee: HERAEUS BATTERY TECHNOLOGY GMBHInventors: Julie Michaud-Bernlochner, Daniel Weingarth, Andreas Kuhn, Dominik Samuelis
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Publication number: 20230075979Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.Type: ApplicationFiled: March 18, 2022Publication date: March 9, 2023Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Publication number: 20230073461Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.Type: ApplicationFiled: March 18, 2022Publication date: March 9, 2023Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Publication number: 20230012716Abstract: A method is for controlling a nuclear power plant comprising pressurized water nuclear reactor (3) having a reactor core producing power, a primary circuit (5) connecting the reactor core to a steam generator (9), one or more of control rods (16), which can be moved into the reactor core for controlling the power of the reactor core, an injecting device (22, 23, 24, 26, 28, 30) for injecting boric acid and/or deionized water into the primary circuit (5) for controlling the reactivity of the reactor core.Type: ApplicationFiled: December 12, 2019Publication date: January 19, 2023Inventors: Andreas KUHN, Klaus-Peter HORNUNG, Dreves HEIKE, Andreas PETRASCH
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Patent number: 11547673Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.Type: GrantFiled: April 16, 2021Date of Patent: January 10, 2023Assignee: BioNTech SEInventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Patent number: 11492628Abstract: The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3?-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.Type: GrantFiled: October 5, 2016Date of Patent: November 8, 2022Assignees: BioNTech SE, TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbHInventors: Alexandra Orlandini Von Niessen, Stephanie Fesser, Britta Vallazza, Tim Beissert, Andreas Kuhn, Ugur Sahin, Marco Alexander Poleganov
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Publication number: 20220341241Abstract: A device for identifying and monitoring the state of an arrangement to be monitored having an openable and closable wing element is provided. The device has a housing, which has a housing base securable on or connected in one piece to the arrangement and a second housing part attachable to and removable from the housing base. The device is also provided with an identification marker, the housing base has a first identification marker for the arrangement to be monitored having an openable and closable wing element, and the second housing part has at least one second identification marker identifying the second housing part.Type: ApplicationFiled: September 2, 2020Publication date: October 27, 2022Inventors: Helge STIER, Andreas KÜHN, Daniel GUSTORFF
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Publication number: 20220273820Abstract: Disclosed herein are RNA polynucleotides comprising a 5? Cap, a 5? UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.Type: ApplicationFiled: December 30, 2021Publication date: September 1, 2022Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci, Gábor Boros, Azita Josefine Mahiny, Jonas Reinholz, Katalin Karikó
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Publication number: 20220249704Abstract: Disclosed herein are RNA polynucleotides comprising a 5? Cap, a 5? UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.Type: ApplicationFiled: December 30, 2021Publication date: August 11, 2022Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci, Gábor Boros, Azita Josefine Mahiny, Jonas Reinholz, Katalin Karikó