Abstract: The present disclosure describes a pharmaceutical formulation of an anti-CD19 antibody.

Abstract: An apparatus for intraoperative neuromonitoring of nerves in the pelvic region of a patient, having at least one nerve stimulator which can be introduced into the operating area during an operation, and a sensor device which can be attached to at least one pelvic organ of the patient. In order to provide an apparatus of this type, by means of which it is possible to reliably monitor, without a significant delay, the integrity/proper functioning of nerves which act on one or more pelvic organs, i.e. in particular the bladder and/or the rectum, during an operation in the pelvic region of a patient, the sensor device includes at least two sensing electrodes, which can be applied to the pelvic organs, and an impedance measuring device, which is or can be connected to the sensing electrodes and has a display showing impedance changes in the pelvic organs between the sensing electrodes.

Abstract: A circuit for generating a radio frequency signal is provided. The circuit includes an amplifier configured to generate a radio frequency signal based on a baseband signal. Further, the circuit includes a power supply configured to generate a variable supply voltage based on a control signal indicating a desired supply voltage, and to supply the variable supply voltage to the amplifier. The circuit further includes an envelope tracking circuit configured to generate the control signal based on a bandwidth of the baseband signal, and to supply the control signal to the power supply.

Abstract: An apparatus for a mobile communication device adapted for digital pre-distortion that includes a memory and a processor operatively coupled to the memory of the processor. The processor receives a first input signal and also receives a first output signal from a power amplifier that is based on the first input signal. The processor additionally varies compression applied to a second input signal based on the first output signal of the power amplifier, generates a distortion compensation vector for the second input signal based on the first output signal of the power amplifier, and also varies an input excitation signal supplied to the power amplifier based on the first output signal of the power amplifier.

Abstract: A circuit for generating a radio frequency signal is provided. The circuit includes an amplifier configured to generate a radio frequency signal based on a baseband signal. Further, the circuit includes a power supply configured to generate a variable supply voltage based on a control signal indicating a desired supply voltage, and to supply the variable supply voltage to the amplifier. The circuit further includes an envelope tracking circuit configured to generate the control signal based on a bandwidth of the baseband signal, and to supply the control signal to the power supply.

Abstract: A device for digital envelope tracking with dynamically changing voltage levels for a radio frequency (RF) power amplifier is disclosed. A power management unit generates a set of supply voltages for a power amplifier based on a control signal. A setpoint generator in the power management integrated circuit gradually increases or decreases a target voltage such that the set of supply voltages output from the voltage converter gradually increase or decrease in response to a gradual transition of the target voltage. A transceiver includes digital models for replicating a behavior of the setpoint generator and a voltage regulator in the voltage converter such that a signal pre-distortion unit may use an instantaneous voltage level for signal predistortion.

Abstract: A data transmission system may comprise a first transmission chain comprising a first transmission power controller, the first transmission power controller being configured to operate in an open loop power control mode or in a closed loop power control mode; a second transmission chain; and a power control mode selector configured to select the first transmission power controller to operate in the open loop power control mode or in the closed loop power control mode based on at least one quantity indicative of interference induced by the second transmission chain in the first transmission power controller when operating in the closed loop power control mode.

Abstract: Systems, circuitries, and methods for predistorting a digital signal in a transmit chain based on a predistortion function are provided. A method includes shifting a center frequency of an input signal by an offset to generate an adapted signal; predistorting the adapted signal based on a predistortion function to generate a predistorted adapted signal; reverting the shifting of the center frequency of the predistorted adapted signal by the offset to generate a predistorted signal; and causing transmission of the predistorted signal by a transmit chain.

Abstract: Systems, circuitries, and methods for predistorting a digital signal in a transmit chain based on a predistortion function are provided in which the function is determined based on a first digital signal or a first transmit chain state. A method includes: receiving a second digital signal that is input to the transmit chain, wherein the transmit chain is characterized by a present transmit chain state; performing a first operation on the second digital signal to generate an adapted digital signal, wherein the first operation is based on either a relationship between the first digital signal and the second digital signal, or a relationship between the first transmit chain state and the present transmit chain state; predistorting the adapted digital signal based on the predistortion function; and performing a second operation on the predistorted adapted signal, wherein the second operation corresponds to an inverse of the first operation.

Abstract: Systems, methods, and circuitries are provided for generating a power amplifier supply voltage based on a target envelope signal for a radio frequency (RF) transmit signal. An envelope tracking system includes a first selector circuitry and predistortion circuitry. The first selector circuitry is disposed in a selector module and is configured to input a plurality of voltages conducted on a first plurality of power lanes, wherein the first plurality of power lanes is part of a power distribution network; select a voltage from the plurality of voltages based on the target envelope signal; and provide the selected voltage to a supply lane connected to an input of the power amplifier that amplifies the RF transmit signal. The predistortion circuitry is configured to modify the RF transmit signal based on a selected power lane of the first plurality of power lanes that conducts the selected voltage.

Abstract: An apparatus for a mobile communication device adapted for digital pre-distortion that includes a memory and a processor operatively coupled to the memory of the processor. The processor receives a first input signal and also receives a first output signal from a power amplifier that is based on the first input signal. The processor additionally varies compression applied to a second input signal based on the first output signal of the power amplifier, generates a distortion compensation vector for the second input signal based on the first output signal of the power amplifier, and also varies an input excitation signal supplied to the power amplifier based on the first output signal of the power amplifier.

Abstract: An apparatus for wireless communication is provided. The apparatus includes a processing circuit configured to receive data to be wirelessly transmitted within a predefined frequency range. Further, the processing circuit is configured to generate a first radio frequency transmit signal of a first frequency range based on the data, and to generate a second radio frequency transmit signal of a second frequency range based on the data. The first frequency range and the second frequency range are subranges of the predefined frequency range. The apparatus further includes a front-end circuit configured to supply the first radio frequency transmit signal to a first antenna, and to supply the second radio frequency transmit signal to a second antenna.

Abstract: A predistortion circuit for a wireless transmitter includes a signal input configured to receive a baseband signal. Further, the predistortion circuit includes a predistorter configured to generate a predistorted baseband signal using the baseband signal and a select of one of a first predistorter configuration and a second predistorter configuration.

Abstract: Systems, methods, and circuitries are provided for generating a power amplifier supply voltage based on a target envelope signal for a radio frequency (RF) transmit signal. An envelope tracking system includes a first selector circuitry and predistortion circuitry. The first selector circuitry is disposed in a selector module and is configured to input a plurality of voltages conducted on a first plurality of power lanes, wherein the first plurality of power lanes is part of a power distribution network; select a voltage from the plurality of voltages based on the target envelope signal; and provide the selected voltage to a supply lane connected to an input of the power amplifier that amplifies the RF transmit signal. The predistortion circuitry is configured to modify the RF transmit signal based on a selected power lane of the first plurality of power lanes that conducts the selected voltage.

Abstract: A device for digital envelope tracking with dynamically changing voltage levels for a radio frequency (RF) power amplifier is disclosed. A power management unit generates a set of supply voltages for a power amplifier based on a control signal. A setpoint generator in the power management integrated circuit gradually increases or decreases a target voltage such that the set of supply voltages output from the voltage converter gradually increase or decrease in response to a gradual transition of the target voltage. A transceiver includes digital models for replicating a behavior of the setpoint generator and a voltage regulator in the voltage converter such that a signal pre-distortion unit may use an instantaneous voltage level for signal predistortion.

Abstract: Systems, circuitries, and methods for predistorting a digital signal in a transmit chain based on a predistortion function are provided in which the function is determined based on a first digital signal or a first transmit chain state. A method includes: receiving a second digital signal that is input to the transmit chain, wherein the transmit chain is characterized by a present transmit chain state; performing a first operation on the second digital signal to generate an adapted digital signal, wherein the first operation is based on either a relationship between the first digital signal and the second digital signal, or a relationship between the first transmit chain state and the present transmit chain state; predistorting the adapted digital signal based on the predistortion function; and performing a second operation on the predistorted adapted signal, wherein the second operation corresponds to an inverse of the first operation.

Abstract: The invention provides antibody formulations and methods useful for prophylaxis or treatment of synucleinopathies, including Parkinson's disease.

Abstract: A method for characterizing the interaction between a protein and a small molecule by detecting a change in fluorescence emitted by a fluorescent dye and a nucleic acid structure which can be used in said method.

Abstract: Systems, methods, and circuitries are provided for generating a power amplifier supply voltage based on a target envelope signal for a radio frequency (RF) transmit signal. An envelope tracking system includes a first selector circuitry and predistortion circuitry. The first selector circuitry is disposed in a selector module and is configured to input a plurality of voltages conducted on a first plurality of power lanes, wherein the first plurality of power lanes is part of a power distribution network; select a voltage from the plurality of voltages based on the target envelope signal; and provide the selected voltage to a supply lane connected to an input of the power amplifier that amplifies the RF transmit signal. The predistortion circuitry is configured to modify the RF transmit signal based on a selected power lane of the first plurality of power lanes that conducts the selected voltage.

Abstract: A data transmission system may comprise a first transmission chain comprising a first transmission power controller, the first transmission power controller being configured to operate in an open loop power control mode or in a closed loop power control mode; a second transmission chain; and a power control mode selector configured to select the first transmission power controller to operate in the open loop power control mode or in the closed loop power control mode based on at least one quantity indicative of interference induced by the second transmission chain in the first transmission power controller when operating in the closed loop power control mode.