Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Abstract: In an embodiment, a radio transmitter may be provided. The radio transmitter may include a radio transmitter control loop; and a controller configured in such a way that it operates the radio transmitter control loop as a closed control loop in a first operating mode, and that it operates the radio transmitter control loop as an open control loop in a second operating mode.

Abstract: An apparatus for amplifying a transmit signal comprises a transmit path comprising a power amplifier module to be coupled to an antenna module. The power amplifier module is configured to amplify a transmit signal. Further, the apparatus comprises an envelope tracking path comprising a variable delay module and a power supply module. The variable delay module is configured to vary a signal delay within the envelope tracking path according to a delay control parameter. Further, the apparatus comprises a delay control module configured to provide the delay control parameter based on a current characteristic transmit frequency of the transmit signal.

Abstract: Representative implementations of devices and techniques provide transmit power detection for an antenna of a wireless system having two or more transmit antennas. A correlation is reduced between a transmit signal of the antenna and signals from other antennas.

Abstract: The present invention is directed to sequencing of nucleic acids. A method is provided for sequencing based on immobilized nucleic acid on a surface. Advantageously, a long range detection mechanism is used for detecting, whether a nucleotide provided to the substrate of a biochip has been incorporated into the immobilized template nucleic acid. Various different alignment means are provided by the present invention which can be used for facilitating a rigidly locking of the orientation of the DNA complex, which complex comprises the template nucleic acid, the primer and the capture nucleic acid. Various different linker systems may be used to immobilize the DNA complex at a first and a second strand end, such that the desired alignment of the DNA complex is achieved. Also co-adsorbed molecules on the substrate surface can be used for such an aligning measure.

Abstract: A transmit circuit includes an envelope tracker configured to determine an envelope of a transmit signal and provide bias information based on the determined envelope of the transmit signal. The transmit circuit further includes a power amplifier configured to generate an RF output signal based on the transmit signal, a bias provider configured to provide a bias for the power amplifier based on the bias information, and an impedance determinator configured to determine a measure of a load impedance of a load coupled to an output of the power amplifier. The envelope tracker is configured to adapt the bias information based on the measure of the load impedance.

Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Abstract: An apparatus for amplifying a transmit signal includes a power amplifier module arranged within a transmit path to be coupled to an antenna module. The power amplifier module is configured to amplify a transmit signal. Further, the apparatus includes a coupling module arranged between the power amplifier module and the antenna module. The coupling module is configured to provide a reverse feedback signal substantially generated by a part of the amplified transmit signal reflected by the antenna module. Further, the apparatus includes a determining module configured to determine a delay information on a delay between the transmit path and an envelope tracking path based on at least the reverse feedback signal. Additionally, the apparatus includes a power supply module arranged within the envelope tracking path configured to vary a power supply of the power amplifier module based on a transmit signal envelope information with a temporal alignment depending on the delay information.

Abstract: An apparatus for amplifying a transmit signal comprises a transmit path comprising a power amplifier module to be coupled to an antenna module. The power amplifier module is configured to amplify a transmit signal. Further, the apparatus comprises an envelope tracking path comprising a variable delay module and a power supply module. The variable delay module is configured to vary a signal delay within the envelope tracking path according to a delay control parameter. Further, the apparatus comprises a delay control module configured to provide the delay control parameter based on a current characteristic transmit frequency of the transmit signal.

Abstract: The invention provides anti-MCAM antibodies that inhibit the ability of human MCAM to bind a laminin alpha-4 chain. The invention also provides pharmaceutical compositions and pharmaceutical formulations, methods of generating such antibodies, and their use in the manufacture of medicaments for treatment of neuroinflammatory disease, autoimmune disease, or cancer.

Abstract: A transmit circuit includes an envelope tracker configured to determine an envelope of a transmit signal and provide bias information based on the determined envelope of the transmit signal. The transmit circuit further includes a power amplifier configured to generate an RF output signal based on the transmit signal, a bias provider configured to provide a bias for the power amplifier based on the bias information, and an impedance determinator configured to determine a measure of a load impedance of a load coupled to an output of the power amplifier. The envelope tracker is configured to adapt the bias information based on the measure of the load impedance.

Abstract: A multi-mode amplifier system includes a supply converter and a multi-stage amplifier. The supply converter is configured to generate a plurality of varied supply signals according to an output power mode. The multi-stage amplifier is configured to generate an RF output signal from an RF input signal according to the varied supply signals.

Abstract: The invention provides antibody formulations and methods useful for prophylaxis or treatment of synucleinopathies, including Parkinson's disease.

Abstract: An apparatus for determining information on a power variation of a transmit signal comprises a power amplifier module, an antenna module and a power variation determining module. The power amplifier module amplifies a radio frequency transmit signal and the antenna module transmits at least partly the amplified radio frequency transmit signal. The power variation determining module determines a weighted sum of a first feedback signal derived from the amplified radio frequency transmit signal and a second feedback signal derived from the amplified radio frequency transmit signal. The first feedback signal and the second feedback signal comprise different dependencies on a varying impedance at the antenna module. Further, the power variation determining module generates a power variation signal based on the weighted sum. The power variation signal comprises information related to a power variation of the amplified radio frequency transmit signal.

Abstract: The disclosure relates to a method for improving the power consumption of a transmission chain by varying the operating point of a power amplifier to optimize (e.g., reduce) the current that is consumed by the amplifier. The operating point is varied by changing the bias voltage(s) (e.g., supply voltage, quiescent voltage) of the amplifier to a predetermined value that is chosen based upon the effect that a given transmitted signal modulation scheme characteristic (e.g., channel bandwidth and/or number of subcarriers) has on the operating point of a power amplifier.

Abstract: A control circuit and a method for controlling an operation of a power amplifier core are provided. The power amplifier core is switchable between an envelope tracking operation mode and a non-envelope tracking operation mode. The control circuit is configured to provide a control signal for controlling the operation of the power amplifier core or to process an amplified signal received from the power amplifier core in dependence on the operation mode of the power amplifier core.

Abstract: An antenna tuner control system includes an RF path, a lookup table and a state table analysis component. The RF path is configured to generate an RF signal. The lookup table has a state table that correlates antenna states with impedance values. The state table analysis component is configured to generate a tuner control signal from the RF signal using the lookup table.

Abstract: A transmit circuit includes an envelope tracker configured to determine an envelope of a transmit signal and provide bias information based on the determined envelope of the transmit signal. The transmit circuit further includes a power amplifier configured to generate an RF output signal based on the transmit signal, a bias provider configured to provide a bias for the power amplifier based on the bias information, and an impedance determinator configured to determine a measure of a load impedance of a load coupled to an output of the power amplifier. The envelope tracker is configured to adapt the bias information based on the measure of the load impedance.

Abstract: An envelope tracking system and a method for adjusting a nonlinear transfer function of an envelope tracking power supply for a power amplifier are provided. An output signal of the power amplifier is provided to a feedback receiver for determining an actual performance of the envelope tracking power amplifier. An assumed performance of the envelope tracking power amplifier is determined by evaluating the non-linear transfer function at a value defined by an input signal for a transmitter including the power amplifier. A difference between the assumed performance and the actual performance provides a correctional value for the nonlinear transfer function.

Abstract: A multi-mode amplifier system includes a supply converter and a multi-stage amplifier. The supply converter is configured to generate a plurality of varied supply signals according to an output power mode. The multi-stage amplifier is configured to generate an RF output signal from an RF input signal according to the varied supply signals.