Abstract: The invention provides antibody formulations and methods useful for prophylaxis or treatment of synucleinopathies, including Parkinson's disease.

Abstract: The present disclosure describes a pharmaceutical formulation of an anti-CD19 antibody.

Abstract: The present invention relates to a method of identifying a nucleotide at a defined position and determining the sequence of a target polynucleotide using an electro-switchable biosensor, as well as devices comprising an electro-switchable biosensor and uses thereof.

Abstract: A communication device comprises a set of filters that are selectively coupled to different groups of front end ports and an antenna port to form a diplexer, a single filter or a no filter connection for transmission and reception of different data signals. A processor operates to selectively determine or combine filters and couple them to the front end ports and the antenna port based on an operational mode and a frequency separation of signals operating in different frequency ranges of different operating bands. The operational mode can alter between a carrier aggregation mode, in which more than one operating band is aggregated during transmission or reception, and a non-carrier aggregation mode, in which only one filter, no filters or the diplexer is bypassed. The insertion loss of the transmissions and receptions can also be actively decreased.

Abstract: The present invention is directed to sequencing of nucleic acids. A method is provided for sequencing based on immobilized nucleic acid on a surface. Advantageously, a long range detection mechanism is used for detecting, whether a nucleotide provided to the substrate of a biochip has been incorporated into the immobilized template nucleic acid. Various different alignment means are provided by the present invention which can be used for facilitating a rigidly locking of the orientation of the DNA complex, which complex comprises the template nucleic acid, the primer and the capture nucleic acid. Various different linker systems may be used to immobilize the DNA complex at a first and a second strand end, such that the desired alignment of the DNA complex is achieved. Also co-adsorbed molecules on the substrate surface can be used for such an aligning measure.

Abstract: A circuit for generating a radio frequency signal is provided. The circuit includes an amplifier configured to generate a radio frequency signal based on a baseband signal. Further, the circuit includes a power supply configured to generate a variable supply voltage based on a control signal indicating a desired supply voltage, and to supply the variable supply voltage to the amplifier. The circuit further includes an envelope tracking circuit configured to generate the control signal based on a bandwidth of the baseband signal, and to supply the control signal to the power supply.

Abstract: An apparatus for determining information on a power variation of a transmit signal comprises a power amplifier module, an antenna module and a power variation determining module. The power amplifier module amplifies a radio frequency transmit signal and the antenna module transmits at least partly the amplified radio frequency transmit signal. The power variation determining module determines a weighted sum of a first feedback signal derived from the amplified radio frequency transmit signal and a second feedback signal derived from the amplified radio frequency transmit signal. The first feedback signal and the second feedback signal comprise different dependencies on a varying impedance at the antenna module. Further, the power variation determining module generates a power variation signal based on the weighted sum. The power variation signal comprises information related to a power variation of the amplified radio frequency transmit signal.

Abstract: Techniques for closed loop power control in multi-transmission systems are discussed. One example system employing such techniques can include coupling circuitry configured to receive a transmission path signal comprising a plurality of signal components, wherein the plurality of signal components comprises at least a first signal component in a first frequency band and a second frequency component in a second frequency band distinct from the first frequency band; filter circuitry configured to receive the transmission path signal from the coupling circuitry, to separate the first signal component from the second signal component, and to separately output the first signal component and the second signal component; and power control circuitry configured to receive the first signal component and the second signal component, and to generate a first power control signal based on the first signal component and a second power control signal based on the second signal component.

Abstract: An apparatus compensates nonlinearities in envelope tracking (ET) used in a mobile device by limiting a bandwidth of an envelope signal representing an envelope of an input baseband signal to be less than a bandwidth of tracker circuitry, generating a scaled replica of an output signal of the tracker circuitry based on the bandwidth-limited envelope signal, and generating a model distortion signal based on the scaled replica and the input baseband signal, where the model distortion signal emulates ET linearity degradation. The apparatus is further configured to generate an output baseband signal based on the scaled replica, the model distortion signal, and the input baseband signal, where the output baseband signal is pre-distorted relative to the input baseband signal according to the scaled replica, the model distortion signal, and the input baseband signal to compensate for degradations in transmit signal quality due to ET nonlinearities.

Abstract: An assembly of a vehicle fixed bodywork panel and a support part for this fixed bodywork panel, comprising one adjustment means in translation of the fixed bodywork panel comprising: a translation member engaging said support part along a member translation axis; a through hole arranged into a first portion of the bodywork panel, the member translation axis being offset from the through-hole, and; a translation coupling element for the translation member and the fixed bodywork panel engaging the through hole, so that moving the translation member along the member translation axis causes a translation of the fixed bodywork panel relative to the support part in a translation direction allowing the fixed bodywork panel to be in a desired position, e.g. flush with a mobile bodywork panel.

Abstract: Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.

Abstract: An apparatus for determining information on a power variation of a transmit signal comprises a power amplifier module, an antenna module and a power variation determining module. The power amplifier module amplifies a radio frequency transmit signal and the antenna module transmits at least partly the amplified radio frequency transmit signal. The power variation determining module determines a weighted sum of a first feedback signal derived from the amplified radio frequency transmit signal and a second feedback signal derived from the amplified radio frequency transmit signal. The first feedback signal and the second feedback signal comprise different dependencies on a varying impedance at the antenna module. Further, the power variation determining module generates a power variation signal based on the weighted sum. The power variation signal comprises information related to a power variation of the amplified radio frequency transmit signal.

Abstract: The invention provides anti-MCAM antibodies that inhibit the ability of human MCAM to bind a laminin alpha-4 chain and pharmaceutical compositions and pharmaceutical formulations incorporating the same for use in treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica (PMR) or Takayasu's arteritis, methods of generating such antibodies, and their use in the manufacture of medicaments for treatment of neuroinflammatory disease, autoimmune disease, or cancer.

Abstract: Techniques for closed loop power control in multi-transmission systems are discussed. One example system employing such techniques can include coupling circuitry configured to receive a transmission path signal comprising a plurality of signal components, wherein the plurality of signal components comprises at least a first signal component in a first frequency band and a second frequency component in a second frequency band distinct from the first frequency band; filter circuitry configured to receive the transmission path signal from the coupling circuitry, to separate the first signal component from the second signal component, and to separately output the first signal component and the second signal component; and power control circuitry configured to receive the first signal component and the second signal component, and to generate a first power control signal based on the first signal component and a second power control signal based on the second signal component.

Abstract: An apparatus for determining information on a power variation of a transmit signal comprises a power amplifier module, an antenna module and a power variation determining module. The power amplifier module amplifies a radio frequency transmit signal and the antenna module transmits at least partly the amplified radio frequency transmit signal. The power variation determining module determines a weighted sum of a first feedback signal derived from the amplified radio frequency transmit signal and a second feedback signal derived from the amplified radio frequency transmit signal. The first feedback signal and the second feedback signal comprise different dependencies on a varying impedance at the antenna module. Further, the power variation determining module generates a power variation signal based on the weighted sum. The power variation signal comprises information related to a power variation of the amplified radio frequency transmit signal.

Abstract: A communication device comprises a set of filters that are selectively coupled to different groups of front end ports and an antenna port to form a diplexer, a single filter or a no filter connection for transmission and reception of different data signals. A processor operates to selectively determine or combine filters and couple them to the front end ports and the antenna port based on an operational mode and a frequency separation of signals operating in different frequency ranges of different operating bands. The operational mode can alter between a carrier aggregation mode, in which more than one operating band is aggregated during transmission or reception, and a non-carrier aggregation mode, in which only one filter, no filters or the diplexer is bypassed. The insertion loss of the transmissions and receptions can also be actively decreased.

Abstract: Compensation for one or more effects of impedance mismatch between a power amplifier (PA) and at least one filter is discussed. One example system that compensates for impedance mismatch with at least one filter comprises a PA, a measurement component, and a feedback component. The PA is configured to receive PA stimuli comprising a supply voltage and a radio frequency (RF) signal to be amplified, wherein a PA output is configured to be coupled to the at least one filter. The measurement component is coupled to the PA and configured to measure an output signal from the PA, wherein the output signal comprises a forward signal associated with the PA and a reflected signal associated with the at least one filter. The feedback component is configured to receive the output signal and to adjust one or more of the PA stimuli based at least in part on the output signal.

Abstract: The present invention relates to a method of identifying a nucleotide at a defined position and determining the sequence of a target polynucleotide using an electro-switchable biosensor, as well as devices comprising an electro-switchable biosensor and uses thereof.

Abstract: Representative implementations of devices and techniques provide transmit power detection for an antenna of a wireless system having two or more transmit antennas. A correlation is reduced between a transmit signal of the antenna and signals from other antennas.

Abstract: A transmit circuit includes an envelope tracker configured to determine an envelope of a transmit signal and provide bias information based on the determined envelope of the transmit signal. The transmit circuit further includes a power amplifier configured to generate an RF output signal based on the transmit signal, a bias provider configured to provide a bias for the power amplifier based on the bias information, and an impedance determinator configured to determine a measure of a load impedance of a load coupled to an output of the power amplifier. The envelope tracker is configured to adapt the bias information based on the measure of the load impedance.