Abstract: A switchable device for supplying at least one consumer of an internal combustion engine with pressure.

Abstract: A switchable device for supplying at least one consumer of an internal combustion engine with pressure.

Abstract: An apparatus for variable setting of control times of gas exchange valves of an internal combustion engine which has an outer and inner rotor rotatable relative to the former, with one component drive-connected to a crankshaft and the other drive-connected to a camshaft. The apparatus has at least one pressure space, which are each divided into two pressure chambers acting counter to one another. The apparatus has a plurality of pressure medium channels, via which pressure medium is fed to or led away from the pressure chambers. Additionally, the apparatus has a plurality of rotational-angle limitation devices assuming an unlocked and locked state. The locking states are set by the supply of pressure medium to or discharge of pressure medium from the respective rotational-angle limitation apparatus. Furthermore, a method for controlling an apparatus for variable setting of control times of gas exchange valves of an internal combustion engine is disclosed.

Abstract: A device (11) for the variable adjusting of the control timing of gas exchange valves (9, 10) of an internal combustion engine (1) with a drive element (13), an output element (14), at least one pressure chamber (23) and a volume accumulator (31), wherein the output element (14) is arranged in a rotatable manner to the drive element (13), and the pressure chamber (23) is bordered at least partially by these components (13, 14), wherein a phase position between the output element (14) and the drive element (13) can be variably adjusted by the pressure medium supply to or pressure medium removal from the pressure chamber (23). Pressure medium lines (25a, b, p) are provided by which the pressure medium can be supplied to the pressure chamber (23) or removed therefrom.

Abstract: A device (10) for variably adjusting control times of gas exchange valves (9a, 9b) of an internal combustion engine (1), including an external rotor (22) and an internal rotor (23) that is arranged such that it can rotate in relation to the external rotor. One of the components is drivingly connected to the crankshaft (2) and the other component is drivingly connected to the camshaft (6, 7). At least one pressure chamber (33) is provided and each of the pressure chambers (33) is divided into two counter-working pressure chambers (35, 36). One of the working chambers (35, 36) of each pressure chamber (33) acts as an advance chamber and the other pressure chamber (35, 36) as a retarding chamber. At least two rotation angle limiting devices (42, 43) are provided, with each of the rotation angle limiting devices (42, 43) being able to assume an unlocked state and locked state.

Abstract: A device for setting the relative rotational position of a camshaft (2, 3) of an internal combustion engine (11) relative to a crankshaft (1) driving the camshaft (2, 3), having a traction mechanism drive (4) wrapping around the crankshaft (1) and the camshaft (2, 3), which includes a loaded traction-mechanism section (8, 9) and a non-loaded traction-mechanism section (7), and a tensioning device (5, 6, 10) for changing the length of the loaded traction-mechanism section (8, 9). The tensioning device (5, 6, 10) is supported on the internal combustion engine (11) and has an adjustment device (20) that can be fixed.

Abstract: The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. It also describes the use of high HER2:HER3 ratio as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a HER inhibitor, such as pertuzumab. In addition, the application describes the use of high HER3 as a selection criterion for treating cancer patients with a chemotherapeutic agent, for instance gemcitabine.

Abstract: The invention relates to a device (11) for variably adjusting the control times of gas exchange valves (9, 10) of an internal combustion engine (1) having a hydraulic phase shifting device (12), a camshaft (6, 7), and a pressure accumulator (15), wherein the phase shifting device (12) can be brought into a drive connection with a crankshaft (2) and is connected to the camshaft (6, 7) in a rotationally fixed manner, wherein a phase position of the camshaft (6, 7) relative to the crankshaft (2) can be variably adjusted by means of the phase shifting device (12) and wherein the interior of the camshaft (6, 7) comprises a cavity (38).

Abstract: The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. It also describes the use of high HER2:HER3 ratio as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a HER inhibitor, such as pertuzumab. In addition, the application describes the use of high HER3 as a selection criterion for treating cancer patients with a chemotherapeutic agent, for instance gemcitabine.

Abstract: A device (10) for variably adjusting control times of gas exchange valves (9a, 9b) of an internal combustion engine (1) is provided, having an external rotor (22) and an internal rotor (23) that is arranged such that it can rotate in relation to the external rotor. One of the components is drivingly connected to the crankshaft (2) and the other component is drivingly connected to the camshaft (6, 7). At least one pressure chamber (33) is provided and each of the pressure chambers (33) is divided into two counter-working pressure chambers (35, 36). One of the pressure chambers (35, 36) of each pressure chamber (33) acts as an advance chamber and the other pressure chamber (35, 36) as a trailing chamber. At least two rotation angle limiting devices (42, 43) are provided, each of the rotation angle limiting devices (42, 43) being able to assume an unlocked state and locking state.

Abstract: The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. It also describes the use of high HER2:HER3 ratio as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a HER inhibitor, such as pertuzumab. In addition, the application describes the use of high HER3 as a selection criterion for treating cancer patients with a chemotherapeutic agent, for instance gemcitabine.

Abstract: A camshaft adjuster (10) for an internal combustion engine which includes a locking mechanism is provided. At least one locking element (21, 22) which can be locked in the zone of a central position (20) as well as at least one additional locking element (23, 24) that can be locked in the zone of a retarded end position (19) or an advanced end position (20) are provided such that the internal combustion engine can be selectively started from an end position (19, 20) or the central position.

Abstract: A camshaft adjuster which has a locking device by which a drive input and drive output part can be rotationally fixedly locked in a locking rotational position. The locking device has a multiplicity of engagement pairs which include one axial bar which is held in the drive input or drive output part and a bar slot which is formed in the respective other part. The engagement pairs are designed such that, during an adjustment of the drive output part in the drive direction, the bars can be placed in successive engagement with the bar slots in a relative rotational position between an end rotational position, which lags behind in the drive direction, and the locking rotational position. The bar slots prevent an adjustment of the drive output part counter to the drive direction and permit an adjustment in the drive direction until the locking rotational position is reached.

Abstract: An apparatus (10) for the variable setting of control times of gas-exchange valves (9a, b) of an internal combustion engine (1) is provided and includes a drive element (22), a driven element (23), at least one pressure chamber (35, 36), a pressurized medium system (37), and a pressure storage device (43). The pressure chamber (35, 36) and the pressure storage device (43) communicate with the pressurized medium system (37), and a phase position between the driven element (23) and the drive element (22) can be changed by supplying pressurized medium to or discharging pressurized medium from the pressure chamber (35, 36) by the pressurized medium system (37).

Abstract: A device and method for enriching and/or depleting substances in a liquid is disclosed. An exemplary device comprises a membrane module that consists essentially of concentric elements and that has a separation element in which the substance to be enriched and/or depleted is carried, and whereby the liquid is carried outside of the separation element. The exemplary device also comprises a drive module that encompasses a drive unit for driving a conveying element that conveys the liquid, the drive unit having a radial magnetic coupling for a central impeller located on the inside. The exemplary device further comprises a conveying module for conveying the liquid through the device, housing the conveying element, whereby the drive module is adapted to be inserted into and removed from the membrane module with a liquid-tight closure. The exemplary device further an oxygenator having an outside fiber bundle and an inside fiber bundle.

Abstract: A modular construction camshaft adjuster for the camshaft drive of an internal combustion engine with a chain or belt wheel, which has at least one wheel rim facing radially outwards with tooth engagement recesses, an annular wheel plate around a central circular opening and an essentially cylindrical wheel wall with a wall thickness, projecting in an axial direction from the annular wheel plate, such that the wheel wall and the wheel plate together form a cup shape. The minimum wall thickness of the essentially cylindrical wheel wall beneath the at least one wheel is equal to half the tooth engagement recess and the cup-shaped chain or belt wheel is made from a lightweight material.

Abstract: The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor alpha, and a HER2 biomarker in a biological sample from the patient and predicting the response to the treatment with the HER inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed.

Abstract: A device (1) for the variable adjustment of control times of an internal combustion engine, including a stator (2), a driven element (3) arranged coaxially thereto, with both components being assembled so as to rotate relative to one another, and both components define at least one pressure chamber (10) at least in the radial and circumferential directions, and a housing (11), separate from the stator (2) and the driven element (3) which encloses the stator (2) and the driven element (3) in an oil-tight manner, whereby the housing (11) seals and defines the pressure chamber in an axial direction.

Abstract: The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor alpha, and a HER2 biomarker in a biological sample from the patient and predicting the response to the treatment with the HER inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed.

Abstract: An apparatus for variable setting of control times of gas exchange valves of an internal combustion engine which has an outer and inner rotor rotatable relative to the former, with one component drive-connected to a crankshaft and the other drive-connected to a camshaft. The apparatus has at least one pressure space, which are each divided into two pressure chambers acting counter to one another. The apparatus has a plurality of pressure medium channels, via which pressure medium is fed to or led away from the pressure chambers. Additionally, the apparatus has a plurality of rotational-angle limitation devices assuming an unlocked and locked state. The locking states are set by the supply of pressure medium to or discharge of pressure medium from the respective rotational-angle limitation apparatus. Furthermore, a method for controlling an apparatus for variable setting of control times of gas exchange valves of an internal combustion engine is disclosed.