Abstract: The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. It also describes the use of high HER2:HER3 ratio as a selection criterion for treating cancer patients, such as ovarian cancer patients, with a HER inhibitor, such as pertuzumab. In addition, the application describes the use of high HER3 as a selection criterion for treating cancer patients with a chemotherapeutic agent, for instance gemcitabine.

Abstract: A device (10) for variably adjusting control times of gas exchange valves (9a, 9b) of an internal combustion engine (1), including an external rotor (22) and an internal rotor (23) that is arranged such that it can rotate in relation to the external rotor. One of the components is drivingly connected to the crankshaft (2) and the other component is drivingly connected to the camshaft (6, 7). At least one pressure chamber (33) is provided and each of the pressure chambers (33) is divided into two counter-working pressure chambers (35, 36). One of the working chambers (35, 36) of each pressure chamber (33) acts as an advance chamber and the other pressure chamber (35, 36) as a retarding chamber. At least two rotation angle limiting devices (42, 43) are provided, with each of the rotation angle limiting devices (42, 43) being able to assume an unlocked state and locked state.

Abstract: A device (10) for variably adjusting control times of gas exchange valves (9a, 9b) of an internal combustion engine (1) is provided, having an external rotor (22) and an internal rotor (23) that is arranged such that it can rotate in relation to the external rotor. One of the components is drivingly connected to the crankshaft (2) and the other component is drivingly connected to the camshaft (6, 7). At least one pressure chamber (33) is provided and each of the pressure chambers (33) is divided into two counter-working pressure chambers (35, 36). One of the pressure chambers (35, 36) of each pressure chamber (33) acts as an advance chamber and the other pressure chamber (35, 36) as a trailing chamber. At least two rotation angle limiting devices (42, 43) are provided, each of the rotation angle limiting devices (42, 43) being able to assume an unlocked state and locking state.

Abstract: A support (30) for the joint hinge of a wiper blade (10) at a hook-shaped end (20) of a bar (18) in a windshield wiper. Owing to an open hub on part of its periphery (28), the support can be slipped on a bearing shank of the wiper blade (10) and, so mounted, be maintained by the hook-shaped end (20) above hub surfaces (46, 62, 66) and ratchet elements (70, 76, 78). The two side walls (32, 34) which are connected by the hub (36) and a plurality of crossbars (60, 64, 70) extend in the longitudinal direction (38), on both sides, towards the hub (34) and the inside widths (40, 42) between the side walls (32, 34) are different at their opposite ends.

Abstract: A device for changing the control times of an internal combustion engine (camshaft adjuster) having a pressure medium distributor arranged within a camshaft is provided. The pressure medium distributor is provided at its front end with a radially extending shoulder, this shoulder forming part of the camshaft axial mounting.

Abstract: A device for setting the relative rotational position of a camshaft (2, 3) of an internal combustion engine (11) relative to a crankshaft (1) driving the camshaft (2, 3), having a traction mechanism drive (4) wrapping around the crankshaft (1) and the camshaft (2, 3), which includes a loaded traction-mechanism section (8, 9) and a non-loaded traction-mechanism section (7), and a tensioning device (5, 6, 10) for changing the length of the loaded traction-mechanism section (8, 9). The tensioning device (5, 6, 10) is supported on the internal combustion engine (11) and has an adjustment device (20) that can be fixed.

Abstract: A control valve for a device for changing the control times of an internal combustion engine, having a substantially hollow-cylindrical valve housing, a control piston which is arranged within the valve housing and can be displaced axially, a pressure medium connection, two operating connections, and at least one tank connection. The operating connections, the pressure medium connection and the tank connection are formed as radial connections. It is possible for the operating connections to be connected to the pressure medium connection and the tank connection by axial displacement of the control piston within the valve housing. The operating connections are arranged adjacently.

Abstract: An apparatus (10) for the variable setting of control times of gas-exchange valves (9a, b) of an internal combustion engine (1) is provided and includes a drive element (22), a driven element (23), at least one pressure chamber (35, 36), a pressurized medium system (37), and a pressure storage device (43). The pressure chamber (35, 36) and the pressure storage device (43) communicate with the pressurized medium system (37), and a phase position between the driven element (23) and the drive element (22) can be changed by supplying pressurized medium to or discharging pressurized medium from the pressure chamber (35, 36) by the pressurized medium system (37).

Abstract: A control valve (18) for a device (1) to modify the timing of an internal combustion engine is provided. Here, a controlled rotation of the camshaft in reference to the crankshaft can be achieved via a hydraulic adjustment drive. A control valve (18) with operative connectors (A, B), a hydraulic connector (P), and at least one reservoir connector (T, T1, T2) controls the inflow of hydraulic fluid into and/or the outflow of hydraulic fluid out of the hydraulic adjustment drive. A filter (46) is arranged between the hydraulic connector (P) and the operative connectors (A, B).

Abstract: An internal-combustion engine with a device for adjusting the rotational angle (camshaft adjuster (1)) of a camshaft (2) relative to a crankshaft is provided. The device comprises a driving wheel (3) connected in a rotationally locked way to the crankshaft, a driven part (6) connected in a rotationally locked way to the camshaft (2), and an adjusting mechanism, with which the phase position between the crankshaft and camshaft (2) can be set and maintained in a certain range of angles. A reduction of the required axial structural space of the camshaft adjuster (1) and the number of individual parts is achieved in that the driven part (6) is fixed to the camshaft (2) with a frictional, positive-fit, or interference-fit connection.

Abstract: A camshaft adjuster (10) for an internal combustion engine which includes a locking mechanism is provided. At least one locking element (21, 22) which can be locked in the zone of a central position (20) as well as at least one additional locking element (23, 24) that can be locked in the zone of a retarded end position (19) or an advanced end position (20) are provided such that the internal combustion engine can be selectively started from an end position (19, 20) or the central position.

Abstract: A device and method for enriching and/or depleting substances in a liquid is disclosed. An exemplary device comprises a membrane module that consists essentially of concentric elements and that has a separation element in which the substance to be enriched and/or depleted is carried, and whereby the liquid is carried outside of the separation element. The exemplary device also comprises a drive module that encompasses a drive unit for driving a conveying element that conveys the liquid, the drive unit having a radial magnetic coupling for a central impeller located on the inside. The exemplary device further comprises a conveying module for conveying the liquid through the device, housing the conveying element, whereby the drive module is adapted to be inserted into and removed from the membrane module with a liquid-tight closure. The exemplary device further an oxygenator having an outside fiber bundle and an inside fiber bundle.

Abstract: A device (1) for the variable adjustment of control times of an internal combustion engine, including a stator (2), a driven element (3) arranged coaxially thereto, with both components being assembled so as to rotate relative to one another, and both components define at least one pressure chamber (10) at least in the radial and circumferential directions, and a housing (11), separate from the stator (2) and the driven element (3) which encloses the stator (2) and the driven element (3) in an oil-tight manner, whereby the housing (11) seals and defines the pressure chamber in an axial direction.

Abstract: The present application describes extending survival in a cancer patient, where the patient is producing an elevated level of EGF or TGF-alpha, by treating the patient with a HER dimerization inhibitor, such as pertuzumab.

Abstract: A device for changing the control times of an internal combustion engine (camshaft adjuster) having a pressure medium distributor arranged within a camshaft is provided. The pressure medium distributor is provided at its front end with a radially extending shoulder, this shoulder forming part of the camshaft axial mounting.

Abstract: A device for changing the control times of an internal combustion engine (camshaft adjuster (1)) having a pressure medium distributor (21) arranged within a camshaft (11) is provided. The pressure medium distributor (21) is provided at its front end with a radially extending shoulder (42), this shoulder (42) forming part of the camshaft axial mounting.

Abstract: A hydraulic device for adjusting the rotation angle of a camshaft relative to a crankshaft in an internal combustion engine. The device has a rotor, with blades arranged around its periphery. A stator is connected in a rotationally secure manner to a drive wheel. The rotor and the stator together form pressure chambers, which can be filled with hydraulic fluid via a hydraulic fluid system, in which there is disposed a volume accumulator.

Abstract: The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor alpha, and a HER2 biomarker in a biological sample from the patient and predicting the response to the treatment with the HER inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed.

Abstract: An internal-combustion engine with a device for adjusting the rotational angle (camshaft adjuster (1)) of a camshaft (2) relative to a crankshaft is provided. The device comprises a driving wheel (3) connected in a rotationally locked way to the crankshaft, a driven part (6) connected in a rotationally locked way to the camshaft (2), and an adjusting mechanism, with which the phase position between the crankshaft and camshaft (2) can be set and maintained in a certain range of angles. A reduction of the required axial structural space of the camshaft adjuster (1) and the number of individual parts is achieved in that the driven part (6) is fixed to the camshaft (2) with a frictional, positive-fit, or interference-fit connection.

Abstract: The invention relates to an apparatus (1) for the variable setting of the control times of gas exchange valves of an internal combustion engine, having a stator (2) and an output element (3) which is arranged coaxially with respect to the former, the two components being mounted such that they can rotate with respect to one another, and having a housing (11) which is configured separately with respect to the stator (2) and with respect to the output element (3) and which surrounds the stator (2) and the output element (3) at least partly and prevents engine oil escaping from the apparatus (1), an outer circumferential surface of the stator (2) being configured in the circumferential direction with a radial profile, into which the housing (11) protrudes in such a way that a form-fitting connection of both components is produced in the circumferential direction.