Abstract: Sortase molecules and methods described herein allow for the construction of a CAR or CAR member, e.g., in situ, on a CARX, e.g., CART, cell. For example, sortase mediated transfer of an antigen binding domain, e.g., a scFv, onto a CAR member having a sortase acceptor motif in place of an antigen binding domain can provide for a complete CAR member on a cell wherein the cell does not comprise nucleic acid that encodes the complete CAR member.

Abstract: Apparatus (1) for reshaping plastic preforms (10) into plastic containers (20) has a blow moulding device (14) which has at least two side parts (14a, 14b) and a base mould (14c) which form a hollow space inside which the plastic preforms (10) are reshaped into the plastic containers (20), wherein the apparatus has a changing device (40) which is suitable and intended either to remove the complete blow moulding device (14) or only parts (14a, 14b, 14c) of the blow moulding device (14) from the blow mould supports (16) thereof and/or to arrange them on the blow mould supports (16), wherein the base mould (14c) is arranged on a base mounting (19), and in a changing mode, through a lifting movement (H) and in particular a lifting and/or lowering of the base mounting (19), the base mould (14c) can be connected to the base mounting (19) or can be disconnected from the base mounting (19), and between the base mounting (19) and the base mould (14c) at least one first disconnectable media connection (21) is provided,

Abstract: A sensor for at least detecting steering torque of a steel steering column includes a magnetic field generating element which is configured to generate a magnetic field. The magnetic field penetrates the steering column so as to magnetize a steel material thereof. The sensor also includes a magnetic field detection element which is configured to detect a magnetic field change caused by a magnetoelastic effect of the magnetized steel material of the steering column when the steering column is subjected to torque stress. An output signal of the magnetic field detection element characterizes steering torque. The sensor also includes a base plate bearing the magnetic field generating element and the magnetic field detection element. The base plate is spaced from and separate from the steel steering column. The magnetic field generating element and the magnetic field detection element are directly mounted on the base plate.

Abstract: An example method includes obtaining user consent to collect and make use of personal information for providing behavioral coaching; obtaining contextual and fitness related information of a user; determining, by inputting the contextual and fitness related information into a model that defines a motivational state, a current motivational state of the user; determining, based at least in part on the current motivational state of the user, a type of information to output as part of the behavioral coaching, wherein the type of information is selected from a group comprising education information, inspirational information, and achievement information; determining, based on the type of information to output, a channel for outputting the type of information as part of the behavioral coaching; and outputting, by the computing device, via the channel, a notification including content of the type of information.

Abstract: A semiconductor device includes a source region and a drain region of a first conductivity type, a body region of a second conductivity type between the source region and the drain region, a gate configured to control current through a channel of the body region, a drift zone of the first conductivity type between the body region and the drain region, a superjunction structure formed by a plurality of regions of the second conductivity type laterally spaced apart from one another by intervening regions of the drift zone, and a diffusion barrier structure disposed along sidewalls of the regions of the second conductivity type of the superjunction structure. The diffusion barrier structure includes alternating layers of Si and oxygen-doped Si and a Si capping layer on the alternating layers of Si and oxygen-doped Si.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: The computer-implemented method includes simulating, by a processor, using an electromagnetic solver including ray launching or ray tracing, multiple rays that reach a vicinity of a receiver of a wireless channel, determining locations of interactions of the rays with an environment of the wireless channel, post-processing, using one or more of the multiple rays, information about received signal at the receiver to obtain temporal variations therein, and determining a characteristic of the wireless channel using results of the post-processing.

Abstract: A cable marker strip includes two rows of cable markers which are arranged behind one another in a cable direction. The cable marker strip includes a labeling track which has one labeling surface for each cable marker, wherein one fastening structure is provided for each cable marker on a fastening surface of the labeling track. The fastening surface lies opposite the labeling surface and has a connecting track and two holding limbs which are connected to the connecting track, which lie opposite one another, and together define a cable receptacle. Starting from the connecting track, spacing the holding limbs from one another decreases in the region of the cable receptacle so that the cable receptacle tapers. A printer for printing the cable marker strip and a method for printing the cable marker strip by way of the printer are also provided. The printer includes a print head which is arranged above pressure bars for the rows of cable markers.

Abstract: A network node transmits a scheduling configuration, over a Single Cell Multicast Control Channel, that indicates whether a single transport block or multiple transport blocks of a Single Cell Multicast Traffic Channel are scheduled. The network node may then transmit a transport block in accordance with the scheduling configuration. Correspondingly, a user equipment receives the scheduling configuration. The UE may then receive a transport block in accordance with the scheduling configuration.

Abstract: A first server receives a set of cryptographic parameters from a second server. The set of cryptographic parameters is received from the second server as part of a secure session establishment between a client device and the second server. The first server accesses a private key that is not stored on the second server. The first server signs the set of cryptographic parameters using the private key. The first server transmits the signed set of cryptographic parameters to the second server. The first server receives, from the second server, a request to generate a premaster secret using a value generated by the second server that is included in the request and generates the premaster secret. The first server transmits the premaster secret to the second server for use in the secure session establishment between the client device and the second server.

Abstract: Naturally-derived compounds having various structures elicit the perception of salty taste or enhance the perception of salty taste of a salt. Food products may include such salty compounds, which may be used to reduce the sodium content, while parting a similar level of saltiness.

Abstract: A device and a method for providing an electrical current to an electrical load is disclosed. In particular, the device comprises a memory storage device for storing a plurality of ideal voltage waveforms; an electronic controller arranged in data communication with the memory storage device, the electronic controller operable to select one of the plurality of ideal voltage waveforms to compute a reference voltage and a switching period based on a predetermined rule; and an electronic switch arranged to receive the switching period to switch the electronic switch between an on state and an off state, wherein the electrical current is calculated based on a function of the reference voltage and the switching period of the electronic switch.

Abstract: A heating system and method for heating the interior of a vehicle, such as a motor vehicle, which has an air-air heat exchanger having a heat storage medium, and which is configured to transfer heat between exhaust air, drawn out of the interior, and intake air, supplied to the interior from the vehicle environment, between the exhaust air and the heat storage medium, and between the intake air and the heat storage medium.

Abstract: An electronic device modifies a first media content item by superimposing a first set of data over a first accented musical event. The first accented musical event has a first audio profile. The first set of data has a second audio profile configured to be masked by the first audio profile during playback of the first media content item. The electronic device transmits, to a second electronic device, the modified first media content item.

Abstract: A coaxial RF connector with inner and outer conductors has an outer conductor with a plurality of longitudinal slits forming a plurality of spring loaded contact elements. A contact sleeve is arranged movable in axial direction surrounding coaxially the outer conductor. The contact sleeve has a radial contact face which is in contact with the spring loaded contact elements and an axial contact face which has a plane orthogonal to the center axis of the connector for contacting a counter connector.

Abstract: A MOSFET includes a semiconductor body having a first side, a drift region, a body region forming a first pn-junction with the drift region, a source region forming a second pn-junction with the body region, in a vertical cross-section, a dielectric structure on the first side and having an upper side; a first gate electrode, a second gate electrode, a contact trench between the first and second gate electrodes, extending through the dielectric structure to the source region, in a horizontal direction a width of the contact trench has, in a first plane, a first value, and, in a second plane, a second value which is at most about 2.5 times the first value, and a first contact structure arranged on the dielectric structure having a through contact portion arranged in the contact trench, and in Ohmic contact with the source region.

Abstract: A combined telemetry system that can be used while drilling a wellbore consists of a multi-hop telemetry method and a single-hop telemetry method combined in parallel. The multi-hop and single-hop methods can be operated in parallel, for example, so that each telemetry method caries data concurrently from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly. The multi-hop and single-hop methods can also be operated in series, for example, so that data from the Measuring-While-Drilling tool located in the Bottom-Hole-Assembly are first carried with the single-hop telemetry method and then transferred to the multi-hop telemetry method at one or more node(s) close to the surface. Preferably, the multi-hop telemetry method can also carry data from along-string sensors. Another combined telemetry system that can be used while drilling a wellbore consists of two single-hop telemetry methods combined in parallel.

Abstract: A method for inspection of a target object, the method including irradiating a reference surface having a non-flat reference profile with radiation; determining reference response data based on detected radiation having interacted with the reference surface; irradiating a target object with radiation, the target object including a target surface having a non-flat target profile corresponding to the reference profile; determining inspection response data based on detected radiation having interacted with the target object; and determining at least one parameter of the target object based on the reference response data and the inspection response data. An alternative method; a control system for controlling an emitter system and a detector system; and an inspection system including a control system, an emitter system and a detector system, are also provided.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating neural network architectures. One of the methods includes receiving a request to determine an architecture for a task neural network; maintaining data specifying a plurality of candidate architectures for the task neural network; repeatedly performing operations comprising: selecting one or more candidate architectures in the maintained data to be modified; generating a new candidate architecture from the selected candidate architecture by, for each hyperparameter in the set of hyperparameters, selecting the value for the hyperparameter for the new candidate architecture; and adding data specifying the new candidate architecture to the maintained data; and selecting, as the final architecture for the task neural network, one of the candidate architectures specified in the maintained data.