Abstract: The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

Abstract: A power-to-X system having an electrolyzer and an energy converter which are connected together via a hydrogen line. The system additionally has a chemical reactor for catalytically removing oxygen, a first heat exchanger, a water separator, a store, and a humidifier which are connected into the hydrogen line in the stated order one behind the other between the electrolyzer and the energy converter. A second heat exchanger is arranged in the hydrogen line such that a first side of the second heat exchanger is arranged in front of the first heat exchanger and a second side of the second heat exchanger is arranged downstream of the water separator in the hydrogen line.

Abstract: A holder for arrangement on a washing basket of a dishwasher includes: a main body and a folding element which is arranged pivotably thereon, the folding element being transferable from a use position to a non-use position and vice versa. The main body has a recess which is open at an edge thereof to receive tubular washware. The folding element has an outer contour corresponding to an inner contour of the recess and, in the use, position at least partially fills the recess flush with a supporting surface provided by the main body.

Abstract: A method for the performance-enhancing driver assistance of a road vehicle driven by a driver and provided with at least two drive wheels driven by at least one electric motor connected to a corresponding vehicular battery pack; the method comprises the steps of defining a dynamic model of the road vehicle; determining a route of a track travelled by the road vehicle; calculating, as a function of the dynamic model of the road vehicle and of the route, a convenience index relative to the use of energy of the vehicular battery pack by the electric motor; subdividing the route (R) into a plurality of sectors assigning to each a relative value of the calculated convenience index; delivering electrical power to the drive wheels according to the value of the convenience index assigned to each sector of the route.

Abstract: An electronic device may include a processor and wireless circuitry with transmit and receive antennas. Radar circuitry may use the transmit and receive antennas to perform spatial ranging on external objects farther than a threshold distance (e.g., 1-2 cm) from the transmit antenna. The wireless circuitry may include a voltage standing wave ration (VSWR) sensor coupled to the transmit antenna to detect the presence of objects within the threshold distance from the transmit antenna. This may serve to cover a blind spot for the radar circuitry near to the transmit antenna. The VSWR sensor may gather background VSWR measurements when other wireless performance metric data for the wireless circuitry is within a predetermined range of satisfactory values. The background VSWR measurements may be subtracted from real time VSWR measurements to perform accurate and robust ultra-short range object detection near to the transmit antenna.

Abstract: A system and method for generating an actuation signal for a robotic system for robot-assisted navigation of a medical object with a curved tip in a hollow organ of a patient. An an X-ray system for image monitoring of the intervention is assigned to the robotic system.

Abstract: The invention relates to a closing cap (11) and a method for producing a closing cap for a container (10) for receiving cosmetic creams, liquids or pasty substances, such as in particular mascara, the closing cap (11) being designed as a material hybrid and having a connective area for establishing a connection realized as a screw connection, bayonet connection or the like between the closing cap (11) and the container (10), the connective area being formed on an inner side (15) of a base body (12) made of metal, plastic or ceramics. The connective area has a plastic material as a contacting material in merely a portion for forming a physical contact between the closing cap (11) and the container (10) and the remaining portions are made of the same material as the base body (12).

Abstract: The present invention relates to a freeze-dried (also called lyophilized) drug nanosuspension. The present freeze-dried drug nanosuspension composition has an acceptable stability of the particle size distribution during storage, including long term storage.

Abstract: A slaughtered pig part processing plant including a conveyor with at least one retaining assembly for a pig part and a pig part deskinner below the conveyor. The deskinner including a knife and a skin gripper, wherein the conveyor is configured for advancing the retaining assembly in a machine direction (T) past the deskinner. A deskinner carrier structure including one or more actuators for moving the deskinner between an upper position and a lower position. The knife and the skin gripper configured for engaging in the upper position skin (S) of the pig part suspended from the retaining assembly advanced to the deskinner by the conveyor, and to progressively cut off and remove the-skin (S) when moved to the lower position.

Abstract: Described herein is an electrodepositable coating material including comprising one or more cathodically electrodepositable resins (A); one or more crosslinking agents (B); and one or more compounds represented by formula (I) where C(R1)(R2) is C?O or CH2; R3 is H or OH; R4 and R5 are H or OH, with the proviso that at least one of R4 and R5 is H; and R6-R7 is C?C or HC—CH. Also described herein is a method of coating a metallic substrate comprising including the steps of dipping a metallic substrate into an electrodeposition bath containing the electrodepositable coating material; switching the substrate as a cathode; depositing the electrodepositable coating material onto the substrate to form a coating layer; and drying and curing the thus formed coating layer. Further described herein is a method of using the compounds of formula (I) as anticorrosion agents in electrodeposition paints and coated substrates.

Abstract: The invention relates to a housing (2) of a switch (1) for railroad applications, which housing has, in a sectional view or when viewed from the side, approximately an L-shaped cross-section, wherein the inputs (6) and outputs (7) project upward approximately vertically on the one leg (4) and the inputs (8) and outputs (9) extend approximately at a right angle thereto from the other leg (5).

Abstract: Welding A welding apparatus is provided for welding a weld seam, in particular a root weld seam, with a reversing welding wire the advancing rate, VD, of which is automatically reduced to a specified minimum rate value, VDmin, by a controller of the welding apparatus if no short-circuit, KS, is detected during an arcing phase within a specific time period, ?t, or within a specific extension, ?s, of the welding wire.

Abstract: A strain relief facility for a coaxial cable that is connectable to an electronics unit via an associated plug, includes two half-shells forming a receiver for the coaxial cable and the associated plug, and a fastening facility to fasten the strain relief facility to the electronics unit, and to fasten the half-shells to one another. The receiver has at least one cable section to receive the coaxial cable and a plug section to receive the plug.

Abstract: A directly-converting X-ray detector includes: a directly-converting sensor material, which is to be maintained at a working temperature, and configured to have a DC voltage applied thereto; a conditioning unit configured to cause a base current to flow through the sensor material; a heating unit for the sensor material, the heating unit configured to be regulated by a regulating unit to maintain the working temperature; and a control device having a plurality of electronics units, which include the regulating unit. When a new configuration and/or a reconfiguration process takes place, the control device is configured to maintain the operation of the conditioning unit, and to interrupt the operation of the heating unit and/or maintain the operation of the heating unit with the control value most recently ascertained in ordinary operation of the regulating unit.

Abstract: A planning device for generating control data for a treatment apparatus which produces at least one cut surface in the cornea by operation of a laser device, and to a treatment apparatus including a planning device of the specified type. Also, a method for generating control data for such a treatment apparatus, and a method of eye surgery. In this case, a rotation of the cut surface about an axis running substantially parallel to the ocular axis is facilitated during the determination of the cut surfaces.

Abstract: Producing a molded body made of opaque quartz glass includes providing SiO2 grains obtained by comminuting quartz glass having a purity of at least 99.9 wt % SiO2, forming a slurry containing a suspension liquid and the SiO2 grains and which has a total solids content, wet grinding the SiO2 grains in the slurry so as to form ground SiO2 grain particles, forming a porous green body from the slurry, and sintering the porous green body. To provide a low cost quartz glass, the wet grinding of the SiO2 grains takes place at least temporarily in the presence of SiO2 nanoparticles, the proportion of which in the total solids content of the slurry is in the range of 0.1 wt % to 10 wt %, and the slurry has a solids content in the range of 76 to 80 wt % after addition of the SiO2 nanoparticles and after the wet grinding.

Abstract: A device for conditioning blood including a heat exchanger module including a heat exchanger fiber layer including heat exchanger fibers to receive a heat exchanger fluid and exchange heat with the blood, a gaseous micro-emboli removal module including a micro-porous fiber layer including micro-porous fibers to receive atmospheric or sub-atmospheric pressures such that at least some gaseous micro-emboli are drawn from the blood through the micro-porous fibers, a gas exchanger module including a gas exchanger fiber layer including gas exchanger fibers to receive a gas mixture and exchange gas with the blood, and a potting material body that embeds the heat exchanger fibers, the micro-porous fibers, and the gas exchanger fibers and defines a blood compartment that extends through the heat exchanger module, the gaseous micro-emboli removal module, and the gas exchanger module.

Abstract: The present disclosure provides methods of treating subjects having obesity, methods of identifying subjects having an increased risk of developing obesity, methods of detecting human G-protein coupled receptor 75 variant nucleic acid molecules and variant polypeptides, and GPR75 variant nucleic acid molecules and variant polypeptides.

Abstract: A glazing unit is provided for producing an aesthetically pleasing effect. The glazing unit may include at least one polymer with a first structured surface to which a photonic structure is applied. The surface can reflect a first partial spectrum of incident electromagnetic radiation, and can transmit a second partial spectrum of incident electromagnetic radiation. A reflected proportion corresponds to a higher harmonic and is in a visible spectral range.

Abstract: An actuating clip (1) for a connector (10), having a cable receptacle (2) for receiving at least one cable; connecting means in order to connect the actuating clip to the connector in such a manner that the actuating clip adjoins the connector at a cable-side end of the connector; surfaces for actuating the connector (10), which are configured to ensure guiding of the connector (10) when the latter is connected to an actuating clip by the surfaces of the actuating clip (1) being able to be gripped by a human hand and/or by a gripping tool, wherein the surfaces of the actuating clip (1) are specifically designed to be gripped by a hand and/or by a gripping tool.