Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

Abstract: An electric power assisted steering system comprises a steering mechanism which operatively connects a steering wheel to the road wheels of the vehicle, an electric motor operatively connected to the steering mechanism; a torque signal generator adapted to produce a torque signal indicative of the torque carried by a portion of the steering mechanism, a column velocity signal generator for producing a column velocity signal indicative of the angular velocity of the steering wheel or steering column and a signal processing unit adapted to receive the output signals from the sensing means and to produce therefrom a torque demand signal representative of a torque to be applied to the steering mechanism by the motor.

Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.

Abstract: Methods of preparing organosilane-functionalized regions on a substrate surface and more specifically fabricating patterned functionalized substrates suitable to be optically read, the methods generally comprising employing a vapor deposition process of an organosilane gas onto a lithographically patterned silicon surface followed by removal of the patterning media in a bath of organic solvents and ultrasonic excitation. The inventive methods provide optimized surface density of functional species while avoiding deleterious effects that can occur when lithographically patterned substrates are exposed to various gaseous species during the functionalization process.

Abstract: A formwork release composition containing formwork release oil, which contains a hydrophobic metal oxide and/or metal sulphide component is disclosed. Photocatalytically active compounds, such as particular semiconductors and in particular TiO2, are particularly suitable. The invention also concerns the use of the formwork release composition for producing exposed concrete. The concrete and mortar products thus produced are characterized by a homogeneous surface with self-cleaning properties that gives an enhanced resistance against weathering and a much longer lasting brilliance and whiteness.

Abstract: An electric power assisted steering system for a vehicle, comprising: a steering mechanism which operatively connects a steering wheel to road wheels of the vehicle, a torque sensor arranged to, in use, produce a torque signal indicative of the torque carried by a portion of the steering mechanism, an electric motor operatively connected to the steering mechanism, a signal processing unit arranged to, in use, produce from the torque signal a torque demand signal representative of a torque to be applied to the steering mechanism by the motor, the signal processing unit comprising a first calculating unit arranged to calculate an initial torque demand signal dependent on the torque signal, and a second calculating unit arranged to, in use, calculate a torque damping signal indicative of an amount the initial torque signal is to be damped in order to generate the torque demand signal, and a motor drive stage arranged to provide, in use, a drive current to the motor responsive to the torque demand signal, in whic

Abstract: Methods of preparing organosilane-functionalized regions on a substrate surface and more specifically fabricating patterned functionalized substrates suitable to be optically read, the methods generally comprising employing a vapor deposition process of an organosilane gas onto a lithographically patterned silicon surface followed by removal of the patterning media in a bath of organic solvents and ultrasonic excitation. The inventive methods provide optimized surface density of functional species while avoiding deleterious effects that can occur when lithographically patterned substrates are exposed to various gaseous species during the functionalization process.

Abstract: Substrates are provided for use in the detection, identification and analysis of biologic or chemical samples that are labeled with a fluorescent label, in which the plane of maximum fluorescence is displaced from a reflective substrate surface so that the intensity maximum of the standing wave interference pattern of incident and reflected probe radiation is enhanced. The format of the substrates includes substantially planar surfaces as well as substrates with introduced variations to the substrate surface, e.g., depressions, wells, pedestals and the like, disposed in arrays or other similar structures such that one or more fluorophore-comprising objects can be attached thereto.

Abstract: A formwork release composition containing formwork release oil, which contains a hydrophobic metal oxide and/or metal sulphide component is disclosed. Photocatalytically active compounds, such as particular semiconductors and in particular TiO2, are particularly suitable. The invention also concerns the use of the formwork release composition for producing exposed concrete. The concrete and mortar products thus produced are characterized by a homogeneous surface with self-cleaning properties that gives an enhanced resistance against weathering and a much longer lasting brilliance and whiteness.

Abstract: Methods are provided for carrying out nucleic acid analysis, including sequence identification, employing voltage and/or controlled electric charge to enhance operation. A device comprises substrates for nucleic acid analysis, a first electrically conductive layer, a first electrically insulative layer of dielectric material on the first conductive layer, a second electrically conductive layer disposed upon the first insulative layer in a pattern to define discrete attachment sites for macromolecules on the first insulative layer, the second conductive layer provided with means for resisting affinity for the macromolecules to impede their attachment to sites on the second conductive layer, and terminals for the first and second conductive layers for applying a voltage pattern between the first and the second conductive layers to control affinity between the macromolecules and the discrete attachment sites.

Abstract: Substrates are provided for use in the detection, identification and analysis of biologic or chemical samples that are labeled with a fluorescent label, in which the plane of maximum fluorescence is displaced from a reflective substrate surface so that the intensity maximum of the standing wave interference pattern of incident and reflected probe radiation is enhanced. The format of the substrates includes substantially planar surfaces as well as substrates with introduced variations to the substrate surface, e.g., depressions, wells, pedestals and the like, disposed in arrays or other similar structures such that one or more fluorophore-comprising objects can be attached thereto.

Abstract: Substrates are provided for use in the detection, identification and analysis of biologic or chemical samples that are labeled with a fluorescent label, in which the plane of maximum fluorescence is displaced from a reflective substrate surface so that the intensity maximum of the standing wave interference pattern of incident and reflected probe radiation is enhanced. The format of the substrates includes substantially planar surfaces as well as substrates with introduced variations to the substrate surface, e.g., depressions, wells, pedestals and the like, disposed in arrays or other similar structures such that one or more fluorophore-comprising objects can be attached thereto.

Abstract: The compounds of formula (I), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C?CH; R2, R3, R4 and R5 are radicals independently selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl and (C1-C4)-alkyl; and R6 is a radical selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl, (C1-C4)-alkyl, R7, CH?CH—R7 and O—CH2—R7; wherein R7 is phenyl or phenyl mono- or independently di-substituted with F, Cl, Br, (C1-C3)-alkoxyl or (C1-C4)-alkyl, exhibit a similar chemotactic index to that of amygdalin (natural product whose chemotaxis profile is similar to that of peptide T) and, consequently, are useful for treating inflammatory and/or allergic dermatophathies, such as psoriasis, and are especially much less toxic than amygdalin.

Abstract: The compounds of formula (1), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C=CH; R2, R3, R4 and R5 are radicals independently selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl and (C1-C4)-alkyl; and R6 is a radical selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkoxyl, (C1-C4)-alkyl, R7, CH=CH-R7 and O-CH2-R7; wherein R7 is phenyl or phenyl mono- or independently di-substituted with F, Cl, Br, (C1-C3)-alkoxyl or (C1-C4)-alkyl, exhibit a similar chemotactic index to that of amygdalin (natural product whose chemotaxis profile is similar to that of peptide T) and, consequently, are useful for treating inflammatory and/or allergic dermatophathies, such as psoriasis, and are especially much less toxic than amygdalin.

Abstract: An electric power assisted steering system comprises a steering mechanism which operatively connects a steering wheel to the road wheels of the vehicle, an electric motor operatively connected to the steering mechanism; a torque signal generator adapted to produce a torque signal indicative of the torque carried by a portion of the steering mechanism, a column velocity signal generator for producing a column velocity signal indicative of the angular velocity of the steering wheel or steering column and a signal processing unit adapted to receive the output signals from the sensing means and to produce therefrom a torque demand signal representative of a torque to be applied to the steering mechanism by the motor.

Abstract: A method for controlling an electric assist motor for providing steering assist in response to a sensed torque signal includes the step of filtering the sensed torque signal to provide a low frequency torque signal and a high frequency torque signal. A low frequency assist torque signal is determined as a function of the low frequency torque signal. A high frequency assist gain signal is determined as a function of the sensed torque signal and a sensed vehicle speed. The high frequency assist gain signal is applied to the high frequency torque signal to determine a high frequency assist torque signal. A torque command signal is determined as a function of the low frequency assist torque signal and the high frequency assist torque signal. The electric assist motor is commanded to provide steering assist in accordance with the torque command signal.

Abstract: An electric power assisted steering system for a vehicle, comprising: a steering mechanism which operatively connects a steering wheel to road wheels of the vehicle, a torque sensor (6) arranged to, in use, produce a torque signal indicative of the torque carried by a portion of the steering mechanism, an electric motor (1) operatively connected to the steering mechanism, a signal processing unit (7) arranged to, in use, produce from the torque signal a torque demand signal (8) representative of a torque to be applied to the steering mechanism by the motor, the signal processing unit comprising a first calculating unit (12) arranged to calculate an initial torque demand signal (10) dependent on the torque signal, and a second calculating unit (13) arranged to, in use, calculate a torque damping signal (11) indicative of an amount the initial torque signal is to be damped in order to generate the torque demand signal, and a motor drive stage arranged to provide, in use, a drive current to the motor responsive

Abstract: The invention relates to a process for the chemical modification of a surface of a support, in which said surface contains available hydroxyl groups and lacks metals or metallic alloys. According to the invention, the surface is treated with orthophosphoric acid. The surface thus treated can be used to immobilize biomolecules, cellular membranes, liposomes, cells or tissue sections. The invention is suitable for use in biotechnology, proteomics, genomics, pharmacology and histology in order to carry out studies on immobilized products.

Abstract: An electric power assisted steering apparatus for a vehicle, comprises a steering mechanism, which operatively connects a steering wheel to the road wheels of the vehicle, an electric motor operatively connected to the steering mechanism, a torque sensing means adapted to produce a first output signal indicative of the torque carried by a portion of the steering mechanism, a vehicle speed sensing means for producing a second output signal indicative of the speed of the vehicle, a signal processing unit adapted to receive the first and second signals and to produce a torque demand signal representative of a torque to be applied to the steering mechanism by the motor; and a motor drive stage adapted to provide a drive current to the motor responsive to the torque demand signal.