Abstract: The present invention is directed to diagnostic methods for differentiating Alzheimer's Disease (AD) patients and Frontotemporal Dementia (FTD) patients versus Healthy Controls. The invention also provides methods for distinguishing between these two neurodegenerative diseases AD and FTD, a method for monitoring the progression of AD and/or FTD, a method for determining the efficacy of an AD and/or FTD therapy and a method for screening compounds to be used against AD and/or FTD.

Abstract: A technique for data sharing among multiple filers that share a volume in a private or public cloud object store is implemented. In this approach, a mechanism is provided to enable a local filer to determine whether other filers that are sharing the volume have a consistent view of new data being written to the cloud object store by the local filer. The begins by associating together a collection of one or more files in a “push class.” On demand, a push operation for the push class is initiated on the local filer. Preferably, the push is managed according to one or more push criteria associated with the push class. Typically, the push operation pushes file data and metadata associated with the one or more files of the push class in respective phases, with the file data being pushed to the cloud during a first phase and the metadata associated with that file data being pushed during a second phase that follows the first phase.

Abstract: A decoy mounting method, system, and apparatus comprises a decoy platform, a mount connected to the decoy platform, and a pole connected to the decoy platform by the mount. The decoy platform comprises a first stand wing, a second stand wing, and a connecting member connecting the first stand wing and the second stand wing. In an embodiment each of the first stand wing and the second stand wing further comprise a bottom section, a sloped wall section, and an upper section. In an embodiment, a motion creating assembly is configured to impart motion on a decoy mounted in the stand system.

Abstract: The present disclosure is directed to a ladder system. A ladder system may comprise a first section comprising: a first rail, a second rail, and a first support connected to the first rail and the second rail; a second section comprising a first leg; a first connector for connecting, either directly or indirectly via one or more second connectors, the first section to the second section; and a ladder system-opening facilitator connected to the first section and the second section, wherein the first section is substantially parallel to the second section when the ladder system is in a closed position, wherein the ladder system-opening facilitator automatically completes an opening action for the ladder system in response to initiation of the opening action, and wherein the first section is angular to the second section when the ladder system is in an open position.

Abstract: A technique for data sharing among multiple filers that share a volume in a private or public cloud object store is implemented. In this approach, a mechanism is provided to enable a local filer to determine whether other filers that are sharing the volume have a consistent view of new data being written to the cloud object store by the local filer. The begins by associating together a collection of one or more files in a “push class.” On demand, a push operation for the push class is initiated on the local filer. Preferably, the push is managed according to one or more push criteria associated with the push class. Typically, the push operation pushes file data and metadata associated with the one or more files of the push class in respective phases, with the file data being pushed to the cloud during a first phase and the metadata associated with that file data being pushed during a second phase that follows the first phase.

Abstract: Aspects of the disclosure are directed to reducing clock-ungating induced voltage droop by determining a maximum frequency value associated with an output clock waveform; modulating a clock frequency of the output clock waveform for a first time duration based on a first programmable mask pattern or a first Boolean function; and determining if either the first programmable mask pattern or the first Boolean function should be changed. In accordance with one aspect, a voltage droop mitigation circuit includes a control logic for receiving an input clock waveform and a clock enable signal waveform and for outputting a gated clock enable signal waveform; a latch coupled to the control logic, the latch for holding a state of the gated clock enable signal waveform and a AND gate coupled to the latch, the AND gate for outputting an output clock waveform.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: A spacer formed of an intermetallic compound, such as nitinol. The spacer includes at least two segments shaped in opposing arches. The unique properties of the intermetallic compound enable the material to be deformed into a planar, insertable shape when the material is cooled below a transition temperature and returns to the undeformed shape when the material returns to an ambient, operational temperature. An expansion mechanism assembly engages with the spacer to apply an expansion force, extending the spacer longitudinally drawing the spacer into the planar configuration. The expansion mechanism assembly can be used to guide the spacer into the desired position within the patient. The spacer control mechanism assembly is subsequently removed, relieving the expansion force, returning the spacer to the natural un-deformed, arched shape as it returns to body temperature. Retention features can be integrated in the spacer to aid in retaining the spacer in location.

Abstract: A system, apparatus, and method for physiological data collection, providing targeted content, and facilitating remote diagnostics. In one embodiment, a kiosk contains physiological data collection devices, electronic computing devices, and targeted-content display devices to automatically collect physiological data regarding a patient and display targeted content specifically tailored to that patient based on the collected data.

Abstract: Aspects of the disclosure are directed to reducing clock-ungating induced voltage droop by determining a maximum frequency value associated with an output clock waveform; modulating a clock frequency of the output clock waveform for a first time duration based on a first programmable mask pattern or a first Boolean function; and determining if either the first programmable mask pattern or the first Boolean function should be changed. In accordance with one aspect, a voltage droop mitigation circuit includes a control logic for receiving an input clock waveform and a clock enable signal waveform and for outputting a gated clock enable signal waveform; a latch coupled to the control logic, the latch for holding a state of the gated clock enable signal waveform and a AND gate coupled to the latch, the AND gate for outputting an output clock waveform.

Abstract: Aspects of the disclosure are directed to reducing clock-ungating induced voltage droop by determining a maximum frequency value associated with an output clock waveform; modulating a clock frequency of the output clock waveform for a first time duration based on a first programmable mask pattern or a first Boolean function; and determining if either the first programmable mask pattern or the first Boolean function should be changed. In accordance with one aspect, a voltage droop mitigation circuit includes a control logic for receiving an input clock waveform and a clock enable signal waveform and for outputting a gated clock enable signal waveform; a latch coupled to the control logic, the latch for holding a state of the gated clock enable signal waveform and a AND gate coupled to the latch, the AND gate for outputting an output clock waveform.

Abstract: The present invention relates to methods for the detection and quantification of apolipoproteins and isoforms thereof in a sample, as well as to predictive methods of the probability of neurodegenerative or cardiovascular disease development based on apolipoprotein levels as determined by the detection methods of the invention.

Abstract: A method of forming an aligner includes dipping a positive mold of teeth in a liquid material to form a liquid layer and curing the liquid layer to form a shell. The shell may include an inner layer including material from the liquid material and an outer layer including material from another liquid material. Prior to dipping the mold in the liquid material, features may be coupled to the layer. The features may be selected from the group consisting of an archwire, a sensor, and a bracket. The mold includes model teeth and a gingival margin on a base. Dipping may be to a predefined depth. A fluid level of the material is positioned proximate the gingival margin. The fluid level may define the edge of the shell. A set of aligners including at least one aligner having an edge that defines an opening and the edge is as-formed.

Abstract: A versioned file system comprises a set of structured data representations. At a first time, an interface creates and exports to a cloud data store a first structured data representation corresponding to a first version of the local file system. The first structured data representation is an XML tree having a root element, one or more directory elements associated with the root element, and one or more file elements associated with a given directory element. Upon a change within the file system, the interface creates and exports a second structured data representation corresponding to a second version of the file system. The second structured data representation differs from the first structured data representation up to and including the root element of the second structured data representation. The interface continues to generate and export the structured data representations to the data store.

Abstract: A method of manufacturing an orthodontic appliance includes plating a first pattern of a material on a substrate to define a layer. Repeating plating of the first material one or more times forms an additional pattern. A layered structure is built up and forms a portion of the orthodontic appliance. A pattern of a second material different from a first material may be plated on the substrate or on a pattern of the first material. The material may be a sacrificial material that may be later removed. The orthodontic appliance may be an archwire or a self-ligating orthodontic bracket having one or more layered structures formed by plating patterns of the material. Plating may include plating patterns of materials so as to form a movable member in place relative to a bracket body.

Abstract: The invention relates to methods for determining the likelihood that a patient with mild cognitive impairment develops Alzheimer's disease based on the determination of the levels of different metabolites, including amino acids, proteins and lipids. The invention also provides a method for diagnosing Alzheimer's disease or mild cognitive impairment in a subject based on the determination of the above metabolites.

Abstract: A versioned file system comprises a set of structured data representations. At a first time, an interface creates and exports to a cloud data store a first structured data representation corresponding to a first version of the local file system. The first structured data representation is an XML tree having a root element, one or more directory elements associated with the root element, and one or more file elements associated with a given directory element. Upon a change within the file system, the interface creates and exports a second structured data representation corresponding to a second version of the file system. The second structured data representation differs from the first structured data representation up to and including the root element of the second structured data representation. The interface continues to generate and export the structured data representations to the data store.

Abstract: An interface between an existing local file system and a data store generates and exports to the data store a versioned file system. The state of the local file system at a given point in time can be determined using the versioned file system. In operation, the interface creates and exports to the data store structured data representations, which correspond to versions of the local file system, as well as actual file system data that these structured data representations represent. A cache associated with the interface stores recently used data and metadata, as well as all write data and metadata waiting to be transferred to the data store. Prior to transfer, one or more data transformations may be applied to the data and metadata. In one embodiment, the data store comprises one or more cloud storage service providers. A content control system is used to configure and manage the interface.

Abstract: An interface between an existing local file system and a data store generates and exports to the data store a versioned file system. The state of the local file system at a given point in time can be determined using the versioned file system. In operation, the interface creates and exports to the data store structured data representations, which correspond to versions of the local file system, as well as actual file system data that these structured data representations represent. A cache associated with the interface stores recently used data and metadata, as well as all write data and metadata waiting to be transferred to the data store. Prior to transfer, one or more data transformations may be applied to the data and metadata. In one embodiment, the data store comprises one or more cloud storage service providers. A content control system is used to configure and manage the interface.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.