Abstract: A coupling system for securing and positioning a reflective marker in a navigation array is disclosed. The coupling system can include a carrier configured to hold the marker with a reflective element for detection by a surgical tracking system in a socket of the array. The carrier can include a body with an exterior for interfacing with the socket and an open end with engagement features for holding a body of the marker. The carrier is configured to visibly present the reflective element of the marker in the socket when the carrier is disposed in the socket. The carrier can be configured to securely hold the marker to the array when the marker is disposed in the carrier and the carrier is disposed in the array such that the marker cannot be removed from the carrier unless the carrier is removed from the socket.

Abstract: A flexible marker system for use with a computer-assisted surgical (CAS) tracking system is disclosed. The system includes a rigid frame or instrument having a plurality of coupling locations each configured to position a navigation marker in a predetermined position and a flexible array configured to be coupled with the rigid frame or instrument. The flexible array can include an elastically deformable body and a plurality of navigation markers, where the flexible array is configured to be coupled to the rigid frame or instrument by stretching the elastically deformable body over the rigid frame or instrument such that each of the plurality of navigation markers is positioned at one of the plurality of coupling locations of the rigid frame or instrument.

Abstract: A fuel mixture includes a fuel, ethanol, and modified graphene oxide (mGO) nanoparticles functionalized with a hydrocarbon. The mGO is less than 1000 ppm of the ethanol, and a blend of the ethanol and the mGO is less than 10% of the fuel mixture.

Abstract: A fuel mixture includes a fuel, ethanol, and modified graphene oxide (mGO) nanoparticles functionalized with a hydrocarbon. The mGO is less than 1000 ppm of the ethanol, and a blend of the ethanol and the mGO is less than 10% of the fuel mixture.

Abstract: A flexible marker system for use with a computer-assisted surgical (CAS) tracking system is disclosed. The system includes a rigid frame or instrument having a plurality of coupling locations each configured to position a navigation marker in a predetermined position and a flexible array configured to be coupled with the rigid frame or instrument. The flexible array can include an elastically deformable body and a plurality of navigation markers, where the flexible array is configured to be coupled to the rigid frame or instrument by stretching the elastically deformable body over the rigid frame or instrument such that each of the plurality of navigation markers is positioned at one of the plurality of coupling locations of the rigid frame or instrument.

Abstract: A coupling system for securing and positioning a reflective marker in a navigation array is disclosed. The coupling system can include a carrier configured to hold the marker with a reflective element for detection by a surgical tracking system in a socket of the array. The carrier can include a body with an exterior for interfacing with the socket and an open end with engagement features for holding a body of the marker. The carrier is configured to visibly present the reflective element of the marker in the socket when the carrier is disposed in the socket. The carrier can be configured to securely hold the marker to the array when the marker is disposed in the carrier and the carrier is disposed in the array such that the marker cannot be removed from the carrier unless the carrier is removed from the socket.

Abstract: A dispenser for dispensing and attaching individual markers to a reference array of a tracking system is described. A housing defines a cavity extending along a longitudinal axis. The housing has a dispensing end defining a dispensing aperture. A plurality of markers are stacked within the cavity. Each marker has a marker attachment feature by which the marker is attachable to an attachment site of a reference array. The dispensing end of the housing provides a retainer which exerts a retaining force on a bottom most marker sufficient to retain the plurality of markers within the cavity but permitting the bottom most marker to be released from the cavity when the bottom most marker has been attached by its attachment feature to the attachment site of the reference array.

Abstract: A trial neck (30) and a method for trialling a neck of an orthopedic implant in a hip replacement procedure. The method includes inserting a broach (10) into a medullary canal of a femur and connecting a distal end of a trial neck to a proximal end (12) of the broach. The trial neck includes a proximal end connectable to a trial head. The trial neck includes a body portion extending along a neck axis (5) of the trial neck between the distal end and the proximal end. The proximal end includes a male connector for connection to a corresponding female connector of a trial head. The male connector includes a plurality of connection members (34A, 34B) extending parallel to the neck axis. The connection members are separated by one or more elongate slots (50) including at least one kink (52) forming an interlock between the connection members separated by that slot. The connection members are resiliently deflectable.

Abstract: Disclosed herein are compositions comprising florpyrauxifen, an agriculturally acceptable salt or ester thereof, or combinations thereof, and a second herbicide, wherein the compositions are safened for use on white clover. The second herbicide may be selected from 2,4-D, amidosulfuron, saflufenacil, an agriculturally acceptable salt or ester thereof, or combinations thereof.

Abstract: Surgical instrument trays and related methods are described. The surgical instrument tray includes a tray having a plurality of side walls and a base which define an interior space. An insert is located within the interior space of the tray and is removable from the interior space. A lid is provided for closing the interior space and which is removable from the tray. The insert has an upper surface including a plurality of outlines, each outline having the shape of the outline of a corresponding surgical instrument or part of a surgical instrument, each outline being in the form of a continuous strip, and wherein each outline has at least one support arranged to receive and releasably hold the corresponding surgical instrument or part of the surgical instrument above and in registration with the outline.

Abstract: A trial neck (30) and a method for trialling a neck of an orthopedic implant in a hip replacement procedure. The method includes inserting a broach (10) into a medullary canal of a femur and connecting a distal end of a trial neck to a proximal end (12) of the broach. The trial neck includes a proximal end connectable to a trial head. The trial neck includes a body portion extending along a neck axis (5) of the trial neck between the distal end and the proximal end. The proximal end includes a male connector for connection to a corresponding female connector of a trial head. The male connector includes a plurality of connection members (34A, 34B) extending parallel to the neck axis. The connection members are separated by one or more elongate slots (50) including at least one kink (52) forming an interlock between the connection members separated by that slot. The connection members are resiliently deflectable.

Abstract: A device and method for inserting a liner into an acetabular cup. The device includes a first portion configured to engage the liner and a rim of the acetabular cup to align a pole of the liner and a pole of the cup along an axis of the device prior to insertion of the liner into the cup. The device also includes a second portion for pushing the liner into the cup. The second portion includes a guide arrangement for engaging a rim of the liner. The second portion is coupled to the first portion for movement of the second portion with respect to the first portion along said axis.

Abstract: An instrument (200) for positioning a hollow cup component (202) of an orthopedic joint prosthesis and assembly thereof are described. The instrument includes a support member (204) having a plurality of jaw members (208) unitarily formed around its periphery. Each of the jaw members has a cup engaging limb (210) extending in a first direction to be received in a recess on an external side wall of the cup component. Each jaw member is pivotable between an engaged position in which the cup engaging limbs are displaced inwardly and a disengaged position in which the cup engaging limbs are displaced outwardly allowing the cup component to be removed from between the jaw members.

Abstract: A cutting block comprises a body having a top surface for guiding a saw blade, and a top plate connected to the body. The top plate can move between a first position in which the top plate is spaced apart from the body and a second position in which the top surface of the top plate is an extension of the top surface of the body. The top plate has first and second resiliently deformable arms extending from it, spaced apart along the top plate, and the body has first and second recesses formed in it extending substantially perpendicularly to the top surface of the body. The first and second arms on the top plate are inserted in the recesses so that the arms and the recesses define the path for movement of the top plate relative to the body between the first and second position.

Abstract: Methods for controlling bevel etch rate of a substrate during plasma processing within a processing chamber includes securing the substrate on a lower electrode within the processing chamber. A power source is provided. A gas mixture is flowed into the processing chamber. A first match arrangement coupled to an upper electrode is adjusted to control current flowing through the upper electrode to change the upper electrode from a grounded state to a floating state. A second match arrangement coupled to a top ring electrode is adjusted to control current flowing through the top ring electrode so as to control plasma formed above a top edge of the substrate. An extension of the upper electrode is lowered during plasma processing so as to minimize a gap between the extension of the upper electrode and the substrate received on the lower electrode, such that the gap is incapable of supporting plasma formed in the processing chamber.

Abstract: A cutting block comprises a body having a top surface for guiding a saw blade, and a top plate connected to the body. The top plate can move between a first position in which the top plate is spaced apart from the body and a second position in which the top surface of the top plate is an extension of the top surface of the body. The top plate has first and second resiliently deformable arms extending from it, spaced apart along the top plate, and the body has first and second recesses formed in it extending substantially perpendicularly to the top surface of the body. The first and second arms on the top plate are inserted in the recesses so that the arms and the recesses define the path for movement of the top plate relative to the body between the first and second position.

Abstract: The invention provides a device for fitting into a hollow component to provide an indication of whether the hollow component has been deformed, which includes a frame which can be fitted in the) component, and an elongate indicator suspendedly connected to the frame, with any deformation of the frame being visualised as a deflection of the indicator.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6 alkyl, or R2 and R3 taken together are —(CH2)3—; or R1 and R2 taken together can be —(CH2)2— and R3 can be —CH3; R4 halo, —CH3, —OCH3, —OCHF2, —OCF3, or —CN; and n can be 0, 1, or 2. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.

Abstract: A device and method for inserting a liner into an acetabular cup. The device includes a first portion configured to engage the liner and a rim of the acetabular cup to align a pole of the liner and a pole of the cup along an axis of the device prior to insertion of the liner into the cup. The device also includes a second portion for pushing the liner into the cup. The second portion includes a guide arrangement for engaging a rim of the liner. The second portion is coupled to the first portion for movement of the second portion with respect to the first portion along said axis.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6 alkyl, or R2 and R3 taken together are —(CH2)3—; or R1 and R2 taken together can be —(CH2)2— and R3 can be —CH3; R4 halo, —CH3, —OCH3, —OCHF2, —OCF3, or —CN; and n can be 0, 1, or 2. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.