Abstract: The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice.

Abstract: A method for generating and using a video-based icon (videcon) in a message, where a videcon comprises a (preferably short) video and an associated code, comprising identifying the code within a message, retrieving the video associated with the code, inserting either the video or a link to the video into the message, and sending the message to its intended recipient.

Abstract: A Trench gate MOS field-effect transistor having a narrow, lightly doped, region extending from a channel accommodating region (3) of same conductivity type immediately adjacent the trench sidewall. The narrow region may be self-aligned to the top of a lower polysilicon shield region in the trench or may extend the complete depth of the trench. The narrow region advantageously relaxes the manufacturing tolerances, which otherwise require close alignment of the upper polysilicon trench gate to the body-drain junction.

Abstract: A triac circuit comprises a triac having first and second main terminals (MT1,MT2) and a gate terminal and a thyristor connected between one of the main terminals (MT1,MT2) and a control terminal of the triac circuit. The thyristor is used to prevent turn on of the triac when it has turned on by temperature induced leakage currents.

Abstract: An assembly and method for anchoring a wall frame to the foundation of a building utilizes an anchor member which can be threaded upon a threaded shank which is connected to and extends upwardly from the foundation, a cable, a first cable vice which is connectable to one end of the cable and being anchorable to a top member of the wall frame which is positioned upon the foundation, a second cable vice which is connectable to the other end of the cable, and a cap member. The second cable vice is anchorable to the cap member, and the cap member is connectable to the anchor member so that when the cable is anchored between the top member of the wall frame and the cap member by way of the first and second cable vices, the cap member can be connected to the anchor member to thereby tension the cable between the top member of the wall frame and the foundation.

Abstract: An extendable edge reference tool is disclosed. A first segment having a extending end and a receptacle end is provided. The receptacle end includes a coupling mechanism for joining a second segment using an over-center locking force to secure said second segment to said first segment. This tool provides for a useful continuous reference edge over extended distances through adjoining segments. Each segment is suitably compact to be easy stowed. The segments are useful individually. The segments can be joined to extend tool to lengths useful in common construction tasks.

Abstract: A leak detector is disclosed. The optical leak detector may include a sensor module for transmitting and receiving signals corresponding to the surface level of a monitored fluid and include leak detection logic for detecting a leak signature. The leak detection logic may be configured to determine if fluid contained in a tank is in a non-full state outside of a normal state and activate an alarm.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.

Abstract: A multi-line chalk reel is disclosed that may be comprised of three or more line reels disposed in a polar arrangement of parallel but distinct rotation axes that has a single method for engaging and disengaging a single drive arrangement to any one spool. This arrangement provides a variety of advantages, including a package solution of useful dimensions and a low part count to minimize parts in assembly. The single drive arrangement reduces cost, and provides for convenient access to individual spools.

Abstract: Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.

Abstract: An extendable edge reference tool is disclosed. A first segment having a extending end and a receptacle end is provided. The receptacle end includes a coupling mechanism for joining a second segment using an over-center locking force to secure said second segment to said first segment. This tool provides for a useful continuous reference edge over extended distances through adjoining segments. Each segment is suitably compact to be easy stowed. The segments are useful individually. The segments can be joined to extend tool to lengths useful in common construction tasks.

Abstract: A Trench gate MOS field-effect transistor having a narrow, lightly doped, region extending from a channel accommodating region (3) of same conductivity type immediately adjacent the trench sidewall. The narrow region may be self-aligned to the top of a lower polysilicon shield region in the trench or may extend the complete depth of the trench. The narrow region advantageously relaxes the manufacturing tolerances, which otherwise require close alignment of the upper polysilicon trench gate to the body-drain junction.

Abstract: The present invention relates to peptide ligands of the melanocortin receptors, in particular the melanocortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as insulin resistance.

Abstract: Mice lacking expression of the Enho gene provide useful tools in the study of the Enho gene and to investigate possible treatments for glucose, lipid and energy metabolism.

Abstract: The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice.

Abstract: An extendable edge reference tool is disclosed. A first segment having a extending end and a receptacle end is provided. The receptacle end includes a coupling mechanism for joining a second segment using an over-center locking force to secure said second segment to said first segment. This tool provides for a useful continuous reference edge over extended distances through adjoining segments. Each segment is suitably compact to be easy stowed. The segments are useful individually. The segments can be joined to extend tool to lengths useful in common construction tasks.

Abstract: The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.