Abstract: The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.

Abstract: A handheld measurement device of an embodiment of the invention includes a distance measurement engine and an angular position measurement engine. A controller controls the distance measurement engine and associates an elevation, azimuth position, or relative angular position from the angular position measurement engine with distance measurements taken from the elevation engine. In preferred operations, each point measured from a target under the control of a user is automatically associated with an elevation and/or azimuth position obtained from the angular position engine. Preferably, the controller determines a set of relative coordinates in space for a plurality of related target points. The controller may then calculate a variety of useful distances, areas, volumes, etc., regarding the plurality of target points.

Abstract: A multi-line chalk reel is disclosed that may be comprised of three or more line reels disposed in a polar arrangement of parallel but distinct rotation axes that has a single method for engaging and disengaging a single drive arrangement to any one spool. This arrangement provides a variety of advantages, including a package solution of useful dimensions and a low part count to minimize parts in assembly. The single drive arrangement reduces cost, and provides for convenient access to individual spools.

Abstract: An assembly and method for anchoring a wall frame to the foundation of a building utilizes an anchor member which can be threaded upon a threaded shank which is connected to and extends upwardly from the foundation, a cable, a first cable vice which is connectable to one end of the cable and being anchorable to a top member of the wall frame which is positioned upon the foundation, a second cable vice which is connectable to the other end of the cable, and a cap member. The second cable vice is anchorable to the cap member, and the cap member is connectable to the anchor member so that when the cable is anchored between the top member of the wall frame and the cap member by way of the first and second cable vices, the cap member can be connected to the anchor member to thereby tension the cable between the top member of the wall frame and the foundation.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.

Abstract: Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.

Abstract: Apparatus and methods of operation of apparatus for the extracorporeal perfusion of organs are provided which support viability and function of an organ such as a liver, generally outside the body. Blood is supplied as described herein to an organ such as a liver under physiological pressure but without forcing blood flow at any particular rate such that the organ is allowed to auto-regulate blood flow. This allows for organ preservation or resuscitation prior to transplantation, maintenance of organs for use in experimental study of isolated liver physiology, and treatment of patients suffering from organ failure.

Abstract: A multi-line chalk reel is disclosed that may be comprised of three or more line reels disposed in a polar arrangement of parallel but distinct rotation axes that has a single method for engaging and disengaging a single drive arrangement to any one spool. This arrangement provides a variety of advantages, including a package solution of useful dimensions and a low part count to minimize parts in assembly. The single drive arrangement reduces cost, and provides for convenient access to individual spools.

Abstract: A fluid connector including a first conduit and a collar is provided. The first conduit is hollow and has a fluid passageway. The collar is also hollow and encircles the first conduit, and includes an externally positioned attachment mechanism. The collar has an internal bore at a first end for inserting a second conduit. Also, a fluid connector assembly is described, which includes the fluid connector, a mating portion and a second conduit. The mating portion is attached to the second conduit and encircles it. The collar is inserted into an internal bore in the mating portion, so that the first conduit is aligned to the second conduit.

Abstract: A handheld measurement device of an embodiment of the invention includes a distance measurement engine and an angular position measurement engine. A controller controls the distance measurement engine and associates an elevation, azimuth position, or relative angular position from the angular position measurement engine with distance measurements taken from the elevation engine. In preferred operations, each point measured from a target under the control of a user is automatically associated with an elevation and/or azimuth position obtained from the angular position engine. Preferably, the controller determines a set of relative coordinates in space for a plurality of related target points. The controller may then calculate a variety of useful distances, areas, volumes, etc., regarding the plurality of target points.

Abstract: A guide system for signal lines includes a guide tube, through which the signal lines are guided, a cooling system which laterally surrounds the guide tube and has at least one coolant chamber and at least one inlet and at least one outlet for the coolant. The coolant chamber is tubular in construction and is hermetically sealed by a seal at least at one end face.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.

Abstract: A force measuring apparatus uses a flexible cantilever beam engaging a tool at one end and a handle at the other end so that a force, normal to the beam, can be applied and delivered to the tool. Mounted in spaced apart longitudinal alignment on each side of the beam, is a tensioned wire, and a vibratory modulator in electromagnetic communication with the wire causing the wire to vibrate. A vibratory sensor is also positioned on each side of the beam in sensory communication with each respective wire.

Abstract: Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.

Abstract: A web server and data warehouse (1) is provided to enable one or more suppliers of goods or services (4) to service one or more customers (10). Communication between the suppliers, customers and web server uses the internet (3) which is accessed using local internet service providers (2, 5, 9, 11) to minimise telephone call costs. The web server (1) provides automated websites by means of which suppliers can set parameters for goods or equipment at the customer sits. The customer sites transmit measured parameters to the website.

Abstract: A system for monitoring the state of resources, that is stocks of consumable items or plant and equipment, at one or more remote sites and for enabling the restoration of those resources to a desired state comprises a central server (1) connected to the internet (3) via a local internet service provider (2). A monitoring unit (8) at each remote site is connected to the server (1) via the internet (3) using respective local internet service providers (9). A controller (4) is connected to the server. The central server (1) provides a web site that the monitoring unit (8) and the controller (4) can access. The monitoring unit (8) transmits data to the server (1) indicating the state of the resources at the remote site to the server using the web site. The server receives processes and stores the data transmitted by the monitoring unit (8).

Abstract: An approved method of chilling carcasses is described which results in less shrinkage and higher quality meat.

Abstract: An improved method of chilling carcasses is described which results in less shrinkage and higher quality meat.