Abstract: A system includes at least one processing circuit including at least one memory and one or more processors configured to: obtain, via a user interface, a non-bounded query relating to a travel trip, the non-bounded query excluding at least one parameter associated with the travel trip; identify, via a first machine learning model, the at least one excluded parameter based on the non-bounded query; identify, via a second machine learning model and from among a first set of travel results that match the non-bounded query and the excluded parameter, a second set of the travel results that meet a presentation threshold of customer popularity based on at least one of a location selected by one or more users or a time selected by the one or more users; and present, via the user interface, one or more travel results of the second set, and the presentation threshold.

Abstract: Provided are compositions comprising vectors for the co-expression of a modified GlcNAc-1-Phosphotransferase gene and a lysosomal enzyme. The gene encoding the lysosomal enzyme is operably linked to a first promoter and the gene encoding the GlcNAc-1-Phosphotransferase is operably linked to a second promoter. Also provided herein are methods of treating a lysosomal storage disorder comprising administering to a subject the compositions of the disclosure.

Abstract: Sequence data is received that specifies at least one sequence of interest. Thereafter, homologous sequence are collected based on the sequence data and are represented in a multiple sequence alignment using a novel search approach. Next, an epistatic model is computed by a first machine learning model that represents a revolutionary landscape of the multiple sequence alignment. Later, a second machine learning model is used to iteratively generate statistical inferences based upon the epistatic model, to result in a candidate pool of sequences comprising variants of the sequence of interest. Data can then be provided which characterizes the candidate pool of sequences.

Abstract: A comfort assembly for a vehicle seat cushion, the comfort system includes a carrier having a thermal device; a spacer layer attached to the B-side of the carrier; and an effector device attached to the spacer layer so that the spacer layer is between the effector device and the B-side of the carrier; the effector device is attached to the carrier before the comfort assembly is installed onto an A-surface of the cushion of the vehicle seat.

Abstract: The invention provides a bifunctional compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, Cy1, Cy2, Cy3, Cy4, Z1, Z2 and the degron are as described herein.

Abstract: This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail. Alternatively, the Degron can be linked to a Targeting Ligand which binds to a Target Protein for protein degradation.

Abstract: A method involves delivering an elongate shaft to a target tissue location, the elongate shaft comprising a flex portion configured to move between a first state and a second state, moving the flex portion from the first state to the second state to facilitate driving a first tissue anchor into the target tissue location, and moving the flex portion from the second state to the first state while maintaining contact between the flex portion and the first tissue anchor.

Abstract: An energy absorption side structure for a vehicle comprises: a first stamped panel having a series of first ridges each extending substantially perpendicular to a longitudinal axis of the first stamped panel; and a second stamped panel assembled to the first stamped panel to form an enclosed space extending substantially an entire length of the longitudinal axis; wherein the energy absorption side structure is configured for attachment to backup structure of the vehicle.

Abstract: The present invention relates to an unmanned aerial vehicle (UAV) for agricultural weed management. The UAV comprises a control and processing unit (20), and a camera (30). The control and processing unit is configured to control the UAV to fly to a location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to control the camera to acquire at least one image relating to the ground at the location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to analyse the at least one image to determine the presence of at least one weed and its location on the ground.

Abstract: The invention features a headset, and systems including the headset, equipped with electrical sensors. The headset is suitable for use by a child and suitable for use in a gaming system, e.g., to train attention.

Abstract: A structural crossmember with battery pack mounting for a vehicle comprises: a crossmember configured to extend between a first side sill of a vehicle body and a second side sill of the vehicle body across from the first side sill, the crossmember having (i) a first linear portion with a distal end at the first sill, (ii) a second linear portion with a distal end at the second side sill, and (iii) an arched portion that couples respective proximate ends of the first and second linear portions to each other; a first mount for a passenger cabin component, the first mount positioned on a first side of the crossmember facing toward a passenger cabin of the vehicle; and a second mount for the battery pack, the second mount positioned on a second side of the crossmember opposite from the first side.

Abstract: Information identifying a message scanning system is encoded into URLs. A document management system can decode the identifying information to verify that a document accessed via a URL was accessed by a trusted entity rather than by an unknown user. The document management system sends a message including a URL to access a document. When a message scanning system known to the document management system reviews the message for threats, it encodes its identity into a modified form of the URL in the message and uses the modified URL to access the resource. The document management system can decode the identity of the messaging system using a decoding key. Based on the identification, the document management system updates records associated with the document to include the document acce by the message scanning system.

Abstract: A platform is described for collecting and providing intelligence regarding security and/or other aspect(s), and for providing an assessment of the security and/or other aspects of the organization based on the collected and analyzed intelligence. In some implementations, the platform may assess security according to a lean security paradigm, and the platform may be described as a lean security intelligence platform. The platform provides a set of integrated tools for measurement, analytics, and reporting of security aspects and/or other aspects of an organization. The platform provides master assessment scores that gauge the maturity levels of the organization's overall security and/or compliance readiness, in some instances in accordance with Lean Security practices and/or principles. The platform provides access to an organization's analysis with respect to various metrics that are monitored over time determine whether the organization's performance is improving (or degrading) with respect to the metrics.

Abstract: A glider system capable of sustained long-term flight includes a fixed-wing glider having a dual fuselage system. The top surface of the glider is covered with a plurality of photovoltaic cells capable of powering onboard sensors, propeller systems, and/or onboard processers. The glider includes wing spars with a composite material covering an inner foam core, with the type of foam core or use of reinforcement materials differs along the length or width of the wing spars. The glider is able to downward facing sacrificial winglets to provide a landing system without the need for bulkier landing gear.

Abstract: A door assembly for a payload bay (10) having an opening (12), the door assembly comprising at least one door (20, 220). The at least one door comprises: a panel section (22, 222) having a first end (24, 224) and a second end (26, 226); and a first mounting member (30, 230) arranged orthogonally to the panel section at the first end and having a first engagement feature (31, 231) having a rotational axis (18, 218) about which the panel section is arranged to rotate. The engagement feature is arranged to engage with a first fixing member (16, 216) on one side of the payload bay to rotatably couple the panel section to the payload bay. The at least one door is arranged to translate between a closed configuration, in which the panel section is arranged in the same plane as the opening, and an open configuration, in which the panel section is arranged at at least 90 degrees to the plane of the opening, by rotating about the rotational axis.

Abstract: A system comprises an anchor (20) comprising an inner helical tissue-engaging element (24); an outer helical tissue-engaging element (22); and a head assembly (29). The head assembly comprises a first head (25), fixed to a proximal end of the inner tissue-engaging element, and a second head (26), fixed to a proximal end of the outer tissue-engaging element. The system further comprises a driver (28), reversibly interfacing with and engaging the first head and the second head, in order to anchor the anchor in the target tissue. Other applications are also described.

Abstract: The disclosed technology for preparing digital samples for synthesis of RF to simulate channels and GNSS satellites using GPUs includes receiving simulated position and velocity of an antenna, dividing the cycle into points to be converted into the synthesized signal, and computing the points. A first LUT includes pseudo random sequences combinable to produce a code that varies over time for encoding the channel, and a second LUT specifies linear combinations of the pseudo random sequences in the first LUT that produce channel codes to produce the digital sample points. Also included is using GPUs to generate the channel code for a point by mapping the channel code and time position, combining the code with data to be encoded, repeatedly applying the using and combining to produce points, using multiple GPU cores to encode sample points concurrently in the cycle, and sending an ordered sequence of points to a converter.

Abstract: The present invention relates to an aerial vehicle (10). aerial vehicle comprises a liquid chemical tank (20), at least one liquid spray unit (30), at least one actuator (40), a plurality of sensors (50), and a processing unit (60). The liquid chemical tank is configured to hold a liquid chemical. The at least one liquid spray unit is configured to spray the liquid chemical. The at least one actuator is configured to operate the at least one liquid spray unit. At least one sensor (51) of the plurality of sensors is configured to measure a speed of the aerial vehicle relative to the ground. At least one sensor (52) of the plurality of sensors is a light detection and ranging (LIDAR) sensor configured to measure the direction and distance of airborne particles relative to the aerial vehicle with respect to a fore-aft axis of the aerial vehicle.

Abstract: A comfort assembly for a vehicle seat cushion, the comfort system includes a carrier having a thermal device; a spacer layer attached to the B-side of the carrier; and an effector device attached to the spacer layer so that the spacer layer is between the effector device and the B-side of the carrier; the effector device is attached to the carrier before the comfort assembly is installed onto an A-surface of the cushion of the vehicle seat.

Abstract: A method includes predicting a first future timeseries for a first variable using a first model, predicting future values for a plurality of second variables using one or more second models, wherein the first variable is a function of the second variables, generating a second future timeseries for the first variable as based on the future values for the plurality of second variables, and providing a composite timeseries forecast for the first variable by combining the first future timeseries and the second future timeseries.