Abstract: An injection device for injecting medicament in a patient comprises a housing configured to house a fluid reservoir that has one of a plurality of volumes of medicament. An injection conduit fluidly coupled to the fluid reservoir defines a fluid pathway from the fluid reservoir to the patient. A firing mechanism is coupled to the fluid reservoir and is configured to expel the medicament from the fluid reservoir through the injection conduit. A volume setting mechanism is coupled to the firing mechanism and is configured to select the one of the plurality of volumes of medicament for the firing mechanism to expel. A dose setting mechanism is configured to select all or a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated.

Abstract: A method of forming an antimicrobial film, including providing a substrate with a polymer coating disposed thereon, the polymer coating including: an antimicrobial material, an inner surface contacting the substrate, and an outer surface opposite the inner surface; and extracting ions from the antimicrobial material toward the outer surface, such that the outer surface interacts with surface microorganisms. A composition, including a polymer; an antimicrobial material; and at least one of an organic solvent and an additive. The antimicrobial material comprises at least one of copper-containing glass particles, copper oxide particles, copper metal particles, copper salts, copper coordination complexes, cuprite crystals, and a combination thereof. Further, the additive can be selected to increase the oxidation resistance of the antimicrobial material.

Abstract: The disclosed technology for preparing digital samples for synthesis of RF to simulate channels and GNSS satellites using GPUs includes receiving simulated position and velocity of an antenna, dividing the cycle into points to be converted into the synthesized signal, and computing the points. A first LUT includes pseudo random sequences combinable to produce a code that varies over time for encoding the channel, and a second LUT specifies linear combinations of the pseudo random sequences in the first LUT that produce channel codes to produce the digital sample points. Also included is using GPUs to generate the channel code for a point by mapping the channel code and time position, combining the code with data to be encoded, repeatedly applying the using and combining to produce points, using multiple GPU cores to encode sample points concurrently in the cycle, and sending an ordered sequence of points to a converter.

Abstract: The present invention relates to methods and means for producing nitrogenase polypeptides in the mitochondria of plant cells. The present disclosure provides plant cells that express one or more MTP-Nif fusions and/or translational NifD-NifK and NifE-NifN fusions. The present disclosure also provides nucleic acid constructs encoding these fusions as well as expression constructs for expression and targeting of the fusions to the mitochondria of plant cells. The present disclosure also provides transgenic plants comprising the plant cells of the invention and products obtained therefrom.

Abstract: The invention provides cereblon binders of Formulas: or pharmaceutically acceptable salts thereof, for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications to treat medical disorders including, but not limited to cancer.

Abstract: Safety conduit system includes a pair of couplings, each including an elongate fitting or housing having barbs at one end and spaced apart teeth at an opposite end. A conduit made of a thermoplastic hose, and stainless steel reinforcement around the hose is attached at each end to the barbed end of a respective coupling. A thread is optionally provided on an outer surface of the housing inward of the barbs so that ferrules on the conduit and having inner threads can threadingly engage with the threads on the couplings and enable the safety conduit system to maintain connection between the conduit and couplings at relatively high fluid flow pressure through the safety conduit system, such as around 40,000 psi.

Abstract: A bone fixation device configured to fix one or more bone segments is provided.

Abstract: An injection device for injecting medicament in a patient comprises a housing configured to house a fluid reservoir that has one of a plurality of volumes of medicament. An injection conduit fluidly coupled to the fluid reservoir defines a fluid pathway from the fluid reservoir to the patient. A firing mechanism is coupled to the fluid reservoir and is configured to expel the medicament from the fluid reservoir through the injection conduit. A volume setting mechanism is coupled to the firing mechanism and is configured to select the one of the plurality of volumes of medicament for the firing mechanism to expel. A dose setting mechanism is configured to select all or a fraction of the one of the plurality of volumes of medicament that is injected from the injection conduit when the firing mechanism is actuated.

Abstract: Novel compounds which act as protein degradation inducing moieties for proto-oncogene tyrosine-protein kinase receptor (RET), which may be either wild type RET or a mutant form of RET.

Abstract: Information identifying a message scanning system is encoded into URLs. A document management system can decode the identifying information to verify that a document accessed via a URL was accessed by a trusted entity rather than by an unknown user. The document management system sends a message including a URL to access a document. When a message scanning system known to the document management system reviews the message for threats, it encodes its identity into a modified form of the URL in the message and uses the modified URL to access the resource. The document management system can decode the identity of the messaging system using a decoding key. Based on the identification, the document management system updates records associated with the document to include the document acce by the message scanning system.

Abstract: The present invention is directed to an electro-optical sensor for high intensity electric field measurement. The electro-optical sensor was used to measure a strong 118 MV/m narrow pulse width (˜33 ns) electric field in the magnetically insulated transmission line (MITL) of a pulsed power accelerator. Accurately measuring these high fields using conventional pulsed power diagnostics is difficult due to the strength of interfering particles and fields. The electro-optical sensor uses a free space laser beam with a dielectric crystal sensor that is highly immune to electromagnetic interference and does not require an external calibration.

Abstract: The present disclosure provides methods and an apparatus for imaging and analysing images of presumed protein deposits in the retina, retinal tissue or retinal structures and discloses methods differentiating or classifying these deposits and other optical signals from retinal structures into 1) whether they contain or do not contain classes, of proteins or protein deposits called amyloids or other proteins and/or protein deposits related to neurodegenerative eye and brain disease(s); 2) which type(s) of amyloid or other proteins or protein deposits they contain, as well as 3) whether the form and/or properties of the deposit are associated with a class of diseases or with one or another specific condition(s) (or disease(s)); whether or not this is a disease or class of disease associated with the retina or more generally with the nervous system, including the brain or 4) classified as associated with one or another level of severity of condition(s), or disease(s).

Abstract: A catheter may include a catheter body, which may include a proximal end, a distal end, and a lumen formed by an inner wall of the catheter body that extends between the proximal end and the distal end along a longitudinal axis. The distal end of the catheter body may include a distal lumen opening disposed on the longitudinal axis. The distal end may also include a leading edge. The leading edge may form the distal lumen opening and may include an upper and a lower portion. The lower portion of the leading edge may be disposed distally to the upper portion of the leading edge.

Abstract: A beverage preparation machine for dispensing beverages comprising: a housing; a first reservoir station; a first reservoir for containing an aqueous medium, the first reservoir being connectable to said first reservoir station; an auxiliary module station for receiving an auxiliary module.

Abstract: New treatments for Ikaros and/or Aiolos mediated disorders are provided that comprise administering an effective amount of a cereblon binder that degrades Ikaros or Aiolos by the ubiquitin proteasome pathway.

Abstract: A door assembly for a payload bay (10) having an opening (12), the door assembly comprising at least one door (20, 220). The at least one door comprises: a panel section (22, 222) having a first end (24, 224) and a second end (26, 226); and a first mounting member (30, 230) arranged orthogonally to the panel section at the first end and having a first engagement feature (31, 231) having a rotational axis (18, 218) about which the panel section is arranged to rotate. The engagement feature is arranged to engage with a first fixing member (16, 216) on one side of the payload bay to rotatably couple the panel section to the payload bay. The at least one door is arranged to translate between a closed configuration, in which the panel section is arranged in the same plane as the opening, and an open configuration, in which the panel section is arranged at at least 90 degrees to the plane of the opening, by rotating about the rotational axis.

Abstract: A method for monitoring an object (20) in the environment of an aircraft (10) on the ground (2), having the steps of: transmitting a communication signal between a communication device arranged on the object (20), in particular a land vehicle, and at least one communication device spatially allocated to the aircraft (10) on the ground (2), and determining spatial location information relating to the object (20) on the basis of the transmitted communication signal. In addition, a device having an interface which is configured to read in data based on the communication signal transmitted between the communication devices, and a determination unit which is configured to determine spatial location information relating to the object (20) on the basis of the data which have been read in. Furthermore, a system for monitoring an object (20) in the environment of an aircraft (10) on the ground (2), having such a device.

Abstract: Present invention provides compounds that cause specifically the degradation of BRAF. The present compounds are useful for the treatment of various cancers.

Abstract: The present invention relates to an unmanned aerial vehicle (UAV) for agricultural weed management. The UAV comprises a control and processing unit (20), and a camera (30). The control and processing unit is configured to control the UAV to fly to a location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to control the camera to acquire at least one image relating to the ground at the location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to analyse the at least one image to determine the presence of at least one weed and its location on the ground.

Abstract: The present invention relates to a method (10) to control weeds comprising the steps of: a) acquiring geopositional information of planted crop seeds on an agricultural field and generating a crop seed map, b) acquiring soil elevation data and the corresponding geopositional information of the soil elevation on the agricultural field where the crop seeds have been planted or are being planted at at least two different time points and generating soil surface profile maps of the agricultural field, the soil surface profile maps showing the soil surface profiles at the at least two different time points, c) comparing the soil surface profile maps and the crop seed map to identify differences in the soil elevation profile that are not associated with seed growth of the planted seeds on the agricultural field, d) generating a weed control agent spray map on the basis of the differences in the identified soil elevations on the agricultural field that are not associated with seed growth of the planted crop seeds on