Abstract: Novel compounds which act as protein degradation inducing moieties for proto-oncogene tyrosine-protein kinase receptor (RET), which may be either wild type RET or a mutant form of RET.

Abstract: Information identifying a message scanning system is encoded into URLs. A document management system can decode the identifying information to verify that a document accessed via a URL was accessed by a trusted entity rather than by an unknown user. The document management system sends a message including a URL to access a document. When a message scanning system known to the document management system reviews the message for threats, it encodes its identity into a modified form of the URL in the message and uses the modified URL to access the resource. The document management system can decode the identity of the messaging system using a decoding key. Based on the identification, the document management system updates records associated with the document to include the document acce by the message scanning system.

Abstract: The present invention is directed to an electro-optical sensor for high intensity electric field measurement. The electro-optical sensor was used to measure a strong 118 MV/m narrow pulse width (˜33 ns) electric field in the magnetically insulated transmission line (MITL) of a pulsed power accelerator. Accurately measuring these high fields using conventional pulsed power diagnostics is difficult due to the strength of interfering particles and fields. The electro-optical sensor uses a free space laser beam with a dielectric crystal sensor that is highly immune to electromagnetic interference and does not require an external calibration.

Abstract: A catheter may include a catheter body, which may include a proximal end, a distal end, and a lumen formed by an inner wall of the catheter body that extends between the proximal end and the distal end along a longitudinal axis. The distal end of the catheter body may include a distal lumen opening disposed on the longitudinal axis. The distal end may also include a leading edge. The leading edge may form the distal lumen opening and may include an upper and a lower portion. The lower portion of the leading edge may be disposed distally to the upper portion of the leading edge.

Abstract: A beverage preparation machine for dispensing beverages comprising: a housing; a first reservoir station; a first reservoir for containing an aqueous medium, the first reservoir being connectable to said first reservoir station; an auxiliary module station for receiving an auxiliary module.

Abstract: New treatments for Ikaros and/or Aiolos mediated disorders are provided that comprise administering an effective amount of a cereblon binder that degrades Ikaros or Aiolos by the ubiquitin proteasome pathway.

Abstract: A method for monitoring an object (20) in the environment of an aircraft (10) on the ground (2), having the steps of: transmitting a communication signal between a communication device arranged on the object (20), in particular a land vehicle, and at least one communication device spatially allocated to the aircraft (10) on the ground (2), and determining spatial location information relating to the object (20) on the basis of the transmitted communication signal. In addition, a device having an interface which is configured to read in data based on the communication signal transmitted between the communication devices, and a determination unit which is configured to determine spatial location information relating to the object (20) on the basis of the data which have been read in. Furthermore, a system for monitoring an object (20) in the environment of an aircraft (10) on the ground (2), having such a device.

Abstract: A door assembly for a payload bay (10) having an opening (12), the door assembly comprising at least one door (20, 220). The at least one door comprises: a panel section (22, 222) having a first end (24, 224) and a second end (26, 226); and a first mounting member (30, 230) arranged orthogonally to the panel section at the first end and having a first engagement feature (31, 231) having a rotational axis (18, 218) about which the panel section is arranged to rotate. The engagement feature is arranged to engage with a first fixing member (16, 216) on one side of the payload bay to rotatably couple the panel section to the payload bay. The at least one door is arranged to translate between a closed configuration, in which the panel section is arranged in the same plane as the opening, and an open configuration, in which the panel section is arranged at at least 90 degrees to the plane of the opening, by rotating about the rotational axis.

Abstract: Present invention provides compounds that cause specifically the degradation of BRAF. The present compounds are useful for the treatment of various cancers.

Abstract: The present invention relates to an unmanned aerial vehicle (UAV) for agricultural weed management. The UAV comprises a control and processing unit (20), and a camera (30). The control and processing unit is configured to control the UAV to fly to a location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to control the camera to acquire at least one image relating to the ground at the location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to analyse the at least one image to determine the presence of at least one weed and its location on the ground.

Abstract: The present invention relates to a method (10) to control weeds comprising the steps of: a) acquiring geopositional information of planted crop seeds on an agricultural field and generating a crop seed map, b) acquiring soil elevation data and the corresponding geopositional information of the soil elevation on the agricultural field where the crop seeds have been planted or are being planted at at least two different time points and generating soil surface profile maps of the agricultural field, the soil surface profile maps showing the soil surface profiles at the at least two different time points, c) comparing the soil surface profile maps and the crop seed map to identify differences in the soil elevation profile that are not associated with seed growth of the planted seeds on the agricultural field, d) generating a weed control agent spray map on the basis of the differences in the identified soil elevations on the agricultural field that are not associated with seed growth of the planted crop seeds on

Abstract: A catheter may include a catheter body, which may include a proximal end, a distal end, and a lumen formed by an inner wall of the catheter body that extends between the proximal end and the distal end along a longitudinal axis. The distal end of the catheter body may include a distal lumen opening disposed on the longitudinal axis. The distal end may also include a leading edge. The leading edge may form the distal lumen opening and may include an upper and a lower portion. The lower portion of the leading edge may be disposed distally to the upper portion of the leading edge.

Abstract: The invention relates to a spray unit comprising an axle (20), a disc (30), a disc shape modifying assembly (40) and a liquid applicator (50). The disc is configured to spin about the axle centred on the centre of the disc. The liquid applicator is configured to apply liquid to a surface of the disc. The disc shape modifying assembly is configured to modify the trajectory of the liquid droplets that leave the spray unit by way of varying the diameter of the disc.

Abstract: Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

Abstract: The invention relates to a spray unit (10) with an axle (20), an atomising disc (30), a spray direction modifying assembly (40), and a liquid applicator (50). The atomising disc is configured to spin about the axle centred on the centre of the disc. The liquid applicator is configured to apply liquid to a surface of the atomising disc. The spray direction modifying assembly is in proximity to the atomising disc. The spray direction modifying assembly comprises at least one air channel (41). The at least one air channel is configured to provide air in proximity to the atomising disc to modify the subsequent trajectory of the liquid droplets that leave the outer edge of the atomising disc.

Abstract: The invention relates to a spray unit comprising an axle (10), a disc (20), a liquid applicator (40) and a spray direction assembly (50). The disc is configured to spin about the axle centred on the centre of the disc. The liquid applicator is configured to apply liquid to a surface of the disc. The spray direction assembly partially surrounds the disc. The inner surface of the spray direction assembly is configured to modify the trajectory of all liquid that leaves the outer edge of the disc.

Abstract: A computer implemented method for rendering a page that includes one or more dynamic design elements into an output video is described. The method comprises processing the page to generate one or more layers, each layer being either a static layer associated with one or more static design elements of the page or a dynamic layer associated with a single dynamic design element of the page. Output frames are then generated using the layers and then encoded into the output video.

Abstract: A method for reducing the number of images or the length of a video from a digital image collection using a social network, includes receiving a digital image collection captured by a user to be viewed by a viewer; wherein the viewer and the user are members of the same social network and using a processor to access the social network to determine a relationship between a viewer and the user. The method further includes using the processor to determine a set of summarization parameters based on the relationship between the viewer and the user and using the processor to reduce the number of images or the length of the video from the digital image collection using the determined set of summarization parameters to be viewed by the viewer.

Abstract: The present invention relates to an unmanned aerial vehicle (UAV) for agricultural field management. The UAV comprises a control and processing unit (20) and a camera (30). The control and processing unit is configured to control the UAV to fly to a location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crop. The control and processing unit is configured to control the camera to acquire at least one image relating to the crop at the location inside the canopy of the crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to analyse the at least one image to determine at least one disease, at least one pest and/or at least one nutritional deficiency.

Abstract: The disclosed technology for preparing digital samples for synthesis of RF to simulate channels and GNSS satellites using GPUs includes receiving simulated position and velocity of an antenna, dividing the cycle into points to be converted into the synthesized signal, and computing the points. A first LUT includes pseudo random sequences combinable to produce a code that varies over time for encoding the channel, and a second LUT specifies linear combinations of the pseudo random sequences in the first LUT that produce channel codes to produce the digital sample points. Also included is using GPUs to generate the channel code for a point by mapping the channel code and time position, combining the code with data to be encoded, repeatedly applying the using and combining to produce points, using multiple GPU cores to encode sample points concurrently in the cycle, and sending an ordered sequence of points to a converter.