Abstract: Alkali-swellable rheology modifier comprising a core-shell polymer comprising a core polymer and a shell comprising at least one shell copolymer layer at least partially cross-linked and containing a mole percent of crosslinking agent greater than the mole percent of crosslinking agent in the core polymer, provided if the mole percent of crosslinking agent in the core polymer is zero, then either the core polymer is greater than 60 wt % of the core-shell polymer; the core polymer comprises at least one associative monomer; at least one shell copolymer layer copolymer comprises at least one associative monomer; and/or the at least one shell copolymer layer that is at least partially cross-linked comprises greater than 3 mole% crosslinking agent.

Abstract: The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AA V) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins.

Abstract: Embodiments are described for a simple convertible utility knife and scraper includes a handle, slide mechanism, and flat spring with a centrally mounted utility blade. The flat spring locks into precut positions in the handle to secure the blade in the desired position, whether in a cutting position or a scraping position. The blade can be partially extended to expose the front of the blade in the cutting position. When the slide is fully extended, the blade can rotate about a central axis to a position perpendicular to the handle and then be retracted into slots at the end of the handle to secure and support the blade in the scraper position.

Abstract: This disclosure details a surgical system and method for changing one or more dimensions of harvested tissue, such an autograft, which is harvested from one location in a patient's body and used for a surgical repair or reconstruction procedure in another location in the patient's body. An example surgical system includes a first press component defining a cavity configured to receive harvested tissue, and a second press component including a projection insertable into the cavity. Further, at least one of the first and second press components are made of a transparent or semi-transparent material such that when harvested tissue is in the cavity and when the projection is inserted into the cavity, the harvested tissue is visible through at least one of the first and second press components.

Abstract: The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AA V) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins.

Abstract: Technologies for identifying and inspecting web page tags include a tag inspection system. The tag inspection system receives configuration information, which includes a seed uniform resource locator. The tag inspection system accesses a web page corresponding to the seed uniform resource locator. A tag of the web page is invoked by the tag inspection system. Tag execution data is received in response to invocation of the tag of the web page. The received tag execution data is analyzed by the tag inspection system. A report is generated based on the analysis of the received tag execution data. Other embodiments are described and claimed.

Abstract: Embodiments are described for a simple convertible utility knife and scraper includes a handle, slide mechanism, and flat spring with a centrally mounted utility blade. The flat spring locks into precut positions in the handle to secure the blade in the desired position, whether in a cutting position or a scraping position. The blade can be partially extended to expose the front of the blade in the cutting position. When the slide is fully extended, the blade can rotate about a central axis to a position perpendicular to the handle and then be retracted into slots at the end of the handle to secure and support the blade in the scraper position.

Abstract: A system for providing a bone cerclage according to an exemplary aspect of the present disclosure includes, among other things, a suture passer including a shaft. The shaft includes a passageway and a slot leading to the passageway. The slot has a variable width along a length of the passageway. A method is also disclosed.

Abstract: The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors.

Abstract: Systems, methods, and articles for performing document intake, such as intake of legal documents. The systems disclosed herein receive pages of documents, automatically group the pages to identify documents in a legal matter, and automatically update a status of the legal matter based on the identified documents. This is achieved by one or more of receiving a file which contains one or more pages, grouping the pages, determining a document type for each group, obtaining a plurality of phases for a legal matter, assigning a phase to each group, and organizing the groups based on the assigned phase for each group.

Abstract: The present disclosure relates to a Medical Pet Garment designed to encase and protect a pet's torso area, in particular a quadruped pet that underwent a medical procedure. The Medical Pet Garment comprises an upper torso portion and a hindquarters flap. The upper torso portion is designed to substantially cover a pet's torso and comprises a top part which substantially covers a pet's back and a bottom part which substantially covers a pet's chest. The hindquarters flap extends from the bottom part opposite to the neck opening. When the Medical Pet Garment is worn by a pet, the hindquarters flap may be positioned over the pet's abdomen and rump and secured in this position by a releasable attachment to the top part. To allow the pet to relieve itself, a user has to simply release the hindquarters flap from the top part and uncover the pet's abdomen and rump. A user may then lay the hindquarters flap against the bottom part of the upper torso portion and releasably secure it there.

Abstract: The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors.

Abstract: A web content inspection system is configured to monitor the activity of web content tags and cookies during interaction with web content. Monitoring may include automated simulations of web content interaction that occur in a virtual browser or environment, as well as real-time monitoring of web content interactions that occur with actual users through a browser or other application. Features may include monitoring of the creation of cookies, writing information to cookies, and reading information from cookies, as well as associating cookies with the tags or scripts that affect them, and displaying such associations in a hierarchical form that indicates the sequence of actions that led to the cookie activity. Other features include monitoring for the presence of high-risk information in plain-text or encoded formats, within a URL or other portion of web content. Other features include determination of overall risk associated with a tag based on its activities.

Abstract: A system and method of employing a computing device to present a graphical user interface (GUI) for a portfolio for a legal matter and to enable a user to input documents from a file to generate events for the portfolio. A file having a plurality of legal documents associated with the portfolio is obtained. The legal documents are extracted from the file using an artificial intelligence model. A name is automatically selected for each respective extracted legal document based on a match between keywords in the document and a list of known legal document names. An event is automatically generated for each document based on the name of the document and data within the document. The portfolio is updated with the plurality of extracted legal documents and the generated events and the plurality of extracted legal documents and the generated events are presented to a user.

Abstract: A system and method for configuring an application is described. A mapping definition defines a mapping between a first level attribute, a second level attribute, and a third level attribute of the application. The first level attribute indicates a goal of an operation of the application. The second level attribute indicates a factor that contributes to the goal. The third level attribute indicating a metric associated with the factor. The system accesses metrics that measure of operations of the application by a plurality of user accounts. A graphical user interface is generated for the first level attribute and displays the metric from the third level attribute that is mapped to the second level attribute for a set of user accounts from the plurality of user accounts based on the mapping definition. The system generates a configuration setting for the application of the set of user accounts based on the metric of the third level attribute.

Abstract: Nucleic acids encoding Parvoviral Rep proteins with a mutated nuclear localization signal (NLS) are provided. Also provided is a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein with a mutated zinc finger domain and a nucleic acid comprising a nucleotide sequence encoding a Parvoviral Rep protein comprising an amino acid mutation at position 43, 57, 79, 97, 120, 179, 305, 484, 493 or 571 with reference to SEQ ID NO: 2. Nucleic acid constructs and cells, such as insect cells, comprising the nucleic acids are provided as well as a method for producing a recombinant Parvoviral virion using the nucleic acids.

Abstract: Technologies for identifying and inspecting web page tags include a tag inspection system. The tag inspection system receives configuration information, which includes a seed uniform resource locator. The tag inspection system accesses a web page corresponding to the seed uniform resource locator. A tag of the web page is invoked by the tag inspection system. Tag execution data is received in response to invocation of the tag of the web page. The received tag execution data is analyzed by the tag inspection system. A report is generated based on the analysis of the received tag execution data. Other embodiments are described and claimed.

Abstract: The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AA V) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins.

Abstract: A method for providing a bone cerclage according to an exemplary aspect of the present disclosure includes, among other things, wrapping suture around a bone, tensioning the suture to tighten the suture relative to the bone, and securing the suture to the bone.