Abstract: A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors.

Abstract: A universal attachment flange to connect equipment utilized to perform a task to various connection arrangements. A universal attachment flange is provided with a plurality of hole patterns to permit a bolted attachment of the flange to other devices that present varying patterns of bolt receiving holes. The universal attachment flange is capable of connection to a variety of four (4) hole patterns and at least one three (3) hole pattern. In one form the universal attachment flange includes a through hole threaded to receive a connection fitting.

Abstract: A method of producing a plurality of transaction cards comprising the steps of providing a plurality of blank cards to which at least one element is to be applied, each card comprising at least one card tag, each card tag carrying production information identifying at least one element to be applied to the card and/or a location on the card at which at least one element is to be applied, wherein the production information carried by at least one of the plurality of card tags differs from the production information carried by at least another one of the plurality of card tags; reading the card tag; sorting the plurality of cards into at least first and second sorted groups based on the production information; and applying the at least one element to the card.

Abstract: Parvoviral capsid with incorporated Gly-Ala repeat region The present invention provides a nucleic acid construct comprising a nucleic acid sequence encoding a parvoviral VP1, VP2 and VP3 capsid proteins comprising an immuno evasion repeat sequence. In addition, the present invention provides a cell comprising such construct, a parvoviral virion comprising a capsid protein that comprises an immune evasion repeat sequence, use of that parvoviral virion in gene therapy and a pharmaceutical composition comprising such parvoviral virion.

Abstract: The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors.

Abstract: The present invention provides a method for enhanced production of a gene product of interest in a cell, using the AAV replication machinery. The present invention further relates to a cell for use in the method of the invention and a non-human transgenic animal or a transgenic plant comprising a cell of the invention.

Abstract: The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors.

Abstract: A method for producing a silicide contact. The method comprises the steps of depositing a metal on a SiC substrate; forming an encapsulating layer on deposited metal; and annealing said deposited metal to form a silicide contact. The encapsulating layer prevents agglomeration and formation of stringers during the annealing process.

Abstract: A protective case for a portable electronic device comprises a first side panel, a second, transparent side panel opposite the first side panel, and a peripheral side panel that is connected to both the first and second side panels. The second, transparent side panel is formed of first and second transparent layers that are bonded together to form a panel having a plurality of uniform, trapped-gas cells, each one fully sealed from all other cells. The transparent side panel enables full visibility of the contents of the case while providing cushioning for the contents. The first side panel also provides cushioning.

Abstract: A universal attachment flange to connect equipment utilized to perform a task to various connection arrangements. A universal attachment flange is provided with a plurality of hole patterns to permit a bolted attachment of the flange to other devices that present varying patterns of bolt receiving holes. The universal attachment flange is capable of connection to a variety of four (4) hole patterns and at least one three (3) hole pattern. In one form the universal attachment flange includes a through hole threaded to receive a connection fitting.

Abstract: A universal attachment flange to connect equipment utilized to perform a task to various connection arrangements. A universal attachment flange is provided with a plurality of hole patterns to permit a bolted attachment of the flange to other devices that present varying patterns of bolt receiving holes. The universal attachment flange is capable of connection to a variety of four (4) hole patterns and at least one three (3) hole pattern. In one form the universal attachment flange includes a through hole threaded to receive a connection fitting.

Abstract: The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation of the parvoviral Rep78 protein is a suboptimal initiation codon that effects partial exon skipping upon expression in insect cells. The insect cell further comprises a second nucleotide sequence comprising at least one parvoviral (AAV) inverted terminal repeat (ITR) nucleotide sequence and a third nucleotide sequence comprising a sequences coding for the parvoviral capsid proteins.

Abstract: A computer implemented image design facility capable of supporting image design by a plurality of users each having browser-based access, comprising: an image design engine capable of presenting an image design interface to a plurality of users via browser software on user computers, said image design engine comprising means for storing image designs resulting from a plurality of user design processes as a corresponding plurality of uniquely identifiable sessions; and a messaging engine to construct an electronic message to a new user identified by an existing one of said plurality of users, said messaging engine being coupled to said image design engine such that it receives session information relating to an image design produced by said existing user and intended by that user to be accessed by said new user.

Abstract: An apparatus includes a data processor; a user interface; a first communication interface through which a call may made; a second communication interface; and a memory that stores information received through the second communication interface. The information is received from at least one mobile communication device when disposed in proximity to the apparatus, such as being received through a Bluetooth link. The data processor is configurable to operate with the user interface, the memory and the first communication interface to initiate a call to the at least one mobile communication device using the stored information. The call is initiated when the at least one mobile communication device is no longer disposed in proximity to the apparatus.

Abstract: A method to serially determine changes in perfusion to tissues is provided. This method involves injecting contrast material into a catheter that is positioned in the blood supply proximal to the targeted tissue of interest, acquiring a time series of images that depicts the uptake of this contrast material within the tissue, deriving semi-quantitative or quantitative perfusion metrics based upon the time series of perfusion images, altering perfusion to the targeted tissue by means of injecting pharmacologic agents or embolic agents into the blood vessels supplying the targeted tissue, repeating the acquisition of perfusion images to serially monitor changes in tissue perfusion after each alteration, and calculating changes in perfusion metrics after each series of perfusion images. This method is used to monitor changes in perfusion to various tissues, including a diverse array of tumors.

Abstract: A method for producing a silicide contact. The method comprises the steps of depositing a metal on a SiC substrate; forming an encapsulating layer on deposited metal; and annealing said deposited metal to form a suicide contact. The encapsulating layer prevents agglomeration and formation of stringers during the annealing process.

Abstract: A multiple input, dual output, electric motor transmission device includes a ring gear and a ring gear motor for driving the ring gear. A first planetary gear set is engaged to the ring gear for geared rotation with respect to the ring gear and a first sun gear is engaged to the first planetary gear set for geared rotation with respect to the first planetary gear set. A first output shaft and a first electric motor are provided, wherein the first output shaft is coupled to a first one of the first planetary gear set and the first sun gear and a rotor of the first electric motor is coupled to a second one of the first planetary gear set and the first sun gear. A second planetary gear set, similar to the first planetary gear set, is also engaged to the ring gear for geared rotation with respect to the ring gear.

Abstract: An automated energy generating and energy using system is provided. The system includes at least one electric energy user, at least one electric energy source, and may also include at least one electric energy storage element. These elements are instrumented so that each electric energy user has a sensor for determining an amount of energy used, each electric energy source has a sensor for determining an amount of energy provided, and electric energy storage element has a sensor for determining an amount of energy available in the storage element. A controller is operatively connected to each energy source, energy storage element and sensor. The controller is configured to control a level of operation of the at least one source of energy based upon at least the amount of energy used and the amount of energy available in the storage element, if employed. In this way, an automated electrical energy system is provided.

Abstract: An audio data security method and apparatus of the present invention verifies a subject audio communication stream. Verification is by a valid audio encoding detection module, a human speech frequency detection module, a human speech pattern detection module, a music frequency detection module, a human speech prosody detection module, a white noise detection module, and an environmental noise detection module.

Abstract: A voice data security method and apparatus of the present invention modifies a subject voice data stream. Modification is by insertion of noise or similar interference effects. The amount of audio distortion is controllable. Audio or voice communications over a data network are thus made secure, and unauthorized use of the data network over voice channels is prevented.