Abstract: A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. Analogs of Mycalolide B have been prepared and tested in breast and ovarian cancer cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells. The compounds have been shown to disrupt actin.

Abstract: An aquaculture system can include an aquafarm with one or more aquatic pods of aquatic organisms and a remote device to manage the aquafarm. An aquatic pod may be associated with an aquatic structure with a buoyancy system and a control device to automatically perform daily farming functions. The aquatic structure may include an enclosure to hold the aquatic organisms. The control device may be configured to use a smart buoyancy assistant to control the buoyancy system and to determine the farming task to perform in response to environmental stimuli. The remote device can receive data representing crop metrics, harvest results, and sensor data. The remote device can aggregate data from multiple aquatic pods and correlate the data to generate aquaculture models to improve the harvest results. The remote device can generate overview and maintenance reports for the aquafarm.

Abstract: Disclosed are a method, a device, and/or a system of a wall-mounted pet accessory to prevent liquid and residue accumulation behind a feeding container. In one aspect, a pet accessory includes a rectangular surface, a first double-headed pin, and a second double-headed pin. The rectangular surface molded from silicone material has a width wider than a height. A first hole and a second hole is formed along the width of the pet accessory. The first double-headed pin includes a lower circular base portion, an upper circular base portion, a cylindrical spacer, and a long cylindrical shaft pin. A first indentation area is created between the lower and upper circular base portions of the first double-headed pin. A second indentation area is created between the lower and upper circular base portions of the second double-headed pin. The long cylindrical shaft pin is used to insert in a vertical surface.

Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least three identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.

Abstract: A drilling system includes a drill string and surface equipment. The drill string includes a mud pulse transmitter. The mud pulse transmitter is configured to provide a first mud pulse transmission at a first rate responsive to drilling, and provide a second mud pulse transmission at a second rate responsive to not drilling. The surface equipment is coupled to the drill string. The surface equipment includes a mud pulse receiver. The mud pulse receiver is configured to receive the first mud pulse transmission at the first rate responsive to drilling, and receive the second mud pulse transmission at the first rate responsive to drilling. The second rate is higher than the first rate.

Abstract: The present disclosure is related to computational methods of determining intrinsic reaction coordinates (IRCs) for chemical transformations (e.g., chemical reactions) via dual nested integration.

Abstract: An aquaculture system can include an aquafarm with one or more aquatic pods of aquatic organisms and a remote device to manage the aquafarm. An aquatic pod may be associated with an aquatic structure with a buoyancy system and a control device to automatically perform daily farming functions. The aquatic structure may include an enclosure to hold the aquatic organisms. The control device may be configured to use a smart buoyancy assistant to control the buoyancy system and to determine the farming task to perform in response to environmental stimuli. The remote device can receive data representing crop metrics, harvest results, and sensor data. The remote device can aggregate data from multiple aquatic pods and correlate the data to generate aquaculture models to improve the harvest results. The remote device can generate overview and maintenance reports for the aquafarm.

Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.

Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, ?-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci to

Abstract: A system for analyzing distinct datasets with a common index is configurable to (i) receive input data that includes a first set of data and a second set of data that share a common index; (ii) perform a clustering operation on the first set of data to generate a set of clustered data comprising groups representing related datapoints; (iii) identify a set of occurrences within the second set of data (where each occurrence is associated with a respective set of coordinates in the common index), (iv) for each of the set of occurrences: (a) localize search space(s) in the common index using the respective set of coordinates for the occurrence, and (b) facilitate analysis of group(s) of the set of clustered data that are located within the search space(s) to determine whether a relationship exists between the group(s) and the occurrence.

Abstract: Templated document stream integration of checklist data includes loading different checklist templates for a generic endpoint in a computing infrastructure, each containing partially filed data and each corresponding to a different security policy hardening the generic endpoint from a cyberthreat. Specific endpoints are then selected in the computing infrastructure and, for each corresponding specific endpoint, a set of checklists generated, each checklist in the set deriving from a different checklist template and including the partially filled data of one of the different checklist templates. Further, remediation data stored in a data store of an enterprise application is merged into each one of the generated checklists in the set. Finally, the enterprise application is updated with respect to the corresponding one of the selected specific endpoints with the different checklists merging the partially filled data and the remediation data.

Abstract: Disclosed herein are system, method, and device embodiments for implementing dynamic codeless logging in an integration platform system. An integration platform may provide a declaratively-configurable asset pre-configured to implement a logging functionality associated with a log point, package the declaratively-configurable asset within an integration application, and receive a selection of the log point associated with the declaratively-configurable asset. In addition, the integration application may generate log information corresponding to the log point based on the selection of the log point and the logging functionality. Further, the integration platform may present the log information within a graphical user interface.

Abstract: Disclosed herein are system, method, and device embodiments for implementing dynamic codeless logging in an integration platform system. An integration platform may provide a declaratively-configurable asset pre-configured to implement a logging functionality associated with a log point, package the declaratively-configurable asset within an integration application, and receive a selection of the log point associated with the declaratively-configurable asset. In addition, the integration application may generate log information corresponding to the log point based on the selection of the log point and the logging functionality. Further, the integration platform may present the log information within a graphical user interface.

Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, ?-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 to

Abstract: A vehicle mounted spreader for spreading materials such as sand, salt, or other granular chemicals onto snow and ice covered road surfaces comprises a hopper for containing the material to be spread, a spinner for spreading the material, a conveyor for conveying the material from the hopper to the spinner, a vehicle speed sensor, a load sensor, and a controller programmed with an intended density of material (e.g., pounds per acre) and desired width of coverage; within the controller the vehicle speed sensor measurement and load sensor inputs are processed to generate outputs to control the speed of the conveyor and spinner, to both control the rate of material distribution and the pattern of material distribution to approach the intended density and width.

Abstract: Disclosed herein are system, method, and device embodiments for implementing dynamic codeless logging in an integration platform system. An integration platform may provide a declaratively-configurable asset pre-configured to implement a logging functionality associated with a log point, package the declaratively-configurable asset within an integration application, and receive a selection of the log point associated with the declaratively-configurable asset. In addition, the integration application may generate log information corresponding to the log point based on the selection of the log point and the logging functionality. Further, the integration platform may present the log information within a graphical user interface.

Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.

Abstract: Disclosed herein are system, method, and device embodiments for implementing dynamic codeless logging in an integration platform system. An integration platform may provide a declaratively-configurable asset pre-configured to implement a logging functionality associated with a log point, package the declaratively-configurable asset within an integration application, and receive a selection of the log point associated with the declaratively-configurable asset. In addition, the integration application may generate log information corresponding to the log point based on the selection of the log point and the logging functionality. Further, the integration platform may present the log information within a graphical user interface.

Abstract: Disclosed herein are system, method, and device embodiments for implementing dynamic codeless logging in an integration platform system. An integration platform may provide a declaratively-configurable asset pre-configured to implement a logging functionality associated with a log point, package the declaratively-configurable asset within an integration application, and receive a selection of the log point associated with the declaratively-configurable asset. In addition, the integration application may generate log information corresponding to the log point based on the selection of the log point and the logging functionality. Further, the integration platform may present the log information within a graphical user interface.

Abstract: Techniques are disclosed for aligning fiducial markers that commonly exist in each of multiple different N-dimensional (N-D) data sets. Notably, the N-D data sets are at least three-dimensional (3D) data sets. A first set and a second set of N-D data are accessed. A set of one or more fiducial markers that commonly exist in both those sets are identified. Based on the fiducial markers, one or more transformations are performed to align the two sets. Performing this alignment process results in at least a selected number of the common fiducial markers that exist in the two sets being within a threshold alignment relative to one another.