Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable bicyclic prostaglandin; L is a linker group; and at least one co-monomer of Formula III J-(Y1-A)n, J represents a linking functional group, n is 2 to 8 preferably 3 to 8; Y1 comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 to C10 alkylene, amino, ether, ester, amide, carbon

Abstract: Disclosed herein are system, method, and device embodiments for implementing dynamic codeless logging in an integration platform system. An integration platform may provide a declaratively-configurable asset pre-configured to implement a logging functionality associated with a log point, package the declaratively-configurable asset within an integration application, and receive a selection of the log point associated with the declaratively-configurable asset. In addition, the integration application may generate log information corresponding to the log point based on the selection of the log point and the logging functionality. Further, the integration platform may present the log information within a graphical user interface.

Abstract: The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: Techniques are disclosed for aligning fiducial markers that commonly exist in each of multiple different N-dimensional (N-D) data sets. Notably, the N-D data sets are at least three-dimensional (3D) data sets. A first set and a second set of N-D data are accessed. A set of one or more fiducial markers that commonly exist in both those sets are identified. Based on the fiducial markers, one or more transformations are performed to align the two sets. Performing this alignment process results in at least a selected number of the common fiducial markers that exist in the two sets being within a threshold alignment relative to one another.

Abstract: Disclosed herein are system, method, and device embodiments for implementing dynamic codeless logging in an integration platform system. An integration platform may provide a declaratively-configurable asset pre-configured to implement a logging functionality associated with a log point, package the declaratively-configurable asset within an integration application, and receive a selection of the log point associated with the declaratively-configurable asset. In addition, the integration application may generate log information corresponding to the log point based on the selection of the log point and the logging functionality. Further, the integration platform may present the log information within a graphical user interface.

Abstract: A method for determining the presence of a copy number imbalance in genomic DNA of a test sample is provided. The method can separately measure hybridization of a single test sample to a first hybridization array and hybridization of a plurality of reference samples to a plurality of other, respective test arrays. A determination of copy number can be based on the best fit reference array, relative to the test array. The best fit can be determined based on the closest or most similar signal-to-noise ratio of the measured signals.

Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.

Abstract: A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. Analogs of Mycalolide B have been prepared and tested in breast and ovarian cancer cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells. The compounds have been shown to disrupt actin.

Abstract: Aquatic structures with adjustable buoyancy constructed in part with a vent valve for a buoyancy control device suitable for divers, where the vent valve may be opened by any combination of over-pressure, manual pressure relief or a powered means, where a force to a valve plug is applied by means of a spring that is constrained to prevent entirely lateral and angular movement but in which movement of the plug in the axis of the seat is unconstrained.

Abstract: A device for the delivery of an agent to an intestinal site has a backing element, a mucoadhesive element for adhering the device to the intestinal site, and a reservoir comprising the agent. The mucoadhesive element includes a polymer, an opposing surface having the capacity to adhere to the intestinal site, and a population of passageway(s) extending from the reservoir to the opposing surface for delivery of the agent from the reservoir to the intestinal site, each of the passageway(s) having a minimum diameter greater than 10 microns, the diameter being determined by cryogenic scanning electron microscopy after 30 minutes of hydration at 20° C. in phosphate buffered saline at pH 6.5.

Abstract: This disclosure describes systems, methods, and computer-readable media related to retargeting online advertisement campaign recommendations for advertisements with multiple items or services. Bids may be based on a combined advertisement creative comprising two or more items or services. Dynamically selecting multiple items at bid time using a retargeting model to determine a potential revenue generation amount associated with an event may increase the probability of a conversion event based on the creative that includes the selected items. In some embodiments, a machine-learned retargeting model may be used to select multiple items to be displayed in an advertisement. The retargeting model may be applied to items that were previously viewed by the consumer and may determine a value for each of the items using factors. A bid may be calculated for each of the selected items using the values determined by the retargeting model.

Abstract: Disclosed herein are system, method, and computer program product embodiments for providing anomaly feedback monitoring and detection. An embodiment operates by determining a first set of data corresponding to an anomaly indicating an undesirable data state for a first application. A subset of data from a second set of data corresponding to the undesirable data state is identified, wherein the second set of data is associated with communications between the first application and a second application. A notification identifying the anomaly is provided. Feedback associated with the anomaly is received. Data corresponding to the anomaly is updated based on the feedback.

Abstract: Disclosed herein are system, method, and device embodiments for implementing log tokenization in an integration platform system. An integration platform may provide a declaratively-configurable logger asset for deployment in an integration-application design tool, and package the declaratively configurable logger asset in an integration application at least partially built via the integration-application design tool. In addition, the integration application may identify sensitive information in original log data of the integration application, and generate modified log data based on tokenization of the sensitive information. Further, the integration application may log the modified log data into a log file.

Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.

Abstract: Disclosed herein are system, method, and device embodiments for implementing flow analysis in an integration platform system. An integration platform may provide a declaratively-configurable asset within an integration-application design tool, configure the declaratively-configurable asset based on declarative configuration information via the integration-application design tool, and package the declaratively-configurable asset into an integration application. Further, the integration platform may calculate a statistic associated with the declaratively-configurable asset based on the declarative configuration information during an execution of the integration application, and cause display of a graphic representation of the declaratively-configurable asset and the statistic in a monitoring tool.

Abstract: Aquatic structures with adjustable buoyancy constructed in part with a vent valve for a buoyancy control device suitable for divers, where the vent valve may be opened by any combination of over-pressure, manual pressure relief or a powered means, where a force to a valve plug is applied by means of a spring that is constrained to prevent entirely lateral and angular movement but in which movement of the plug in the axis of the seat is unconstrained.

Abstract: The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: Disclosed are methods for determining a genetic origin of fetal cellular DNA obtained from a pregnant female who is carrying a fetus in a current pregnancy. Methods are also disclosed for using the fetal cellular DNA and fetal cell-free DNA (cfDNA) to determine fetal genetic conditions such as copy number variations. The methods disclosed uses a probabilistic model to determine fetal cellular DNA origin based on alleles observed at informative genetic marker of the fetal cellular DNA. Systems and computer program products for performing the methods are also disclosed.

Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.

Abstract: An aquaculture system can include an aquafarm with one or more aquatic pods of aquatic organisms and a remote device to manage the aquafarm. An aquatic pod may be associated with an aquatic structure with a buoyancy system and a control device to automatically perform daily farming functions. The aquatic structure may include an enclosure to hold the aquatic organisms. The control device may be configured to use a smart buoyancy assistant to control the buoyancy system and to determine the farming task to perform in response to environmental stimuli. The remote device can receive data representing crop metrics, harvest results, and sensor data. The remote device can aggregate data from multiple aquatic pods and correlate the data to generate aquaculture models to improve the harvest results. The remote device can generate overview and maintenance reports for the aquafarm.