Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.

Abstract: Systems and methods for generating images from an autonomous vehicle ride. The images can include images from inside the vehicle and outside the vehicle, and can be used to create a highlight reel of the ride. The images can be captured automatically and include images of passengers during the ride. The highlight reel is provided to a user who can choose to share it with others.

Abstract: Methods and systems for creating a multi-applicant account profile are described. During a first remote session, a first applicant provides at least two pieces of contact data for second applicant. A unique link and a one-time password are transmitted to the second applicant using respective first and second pieces of contact data. A second remote session is initiated, in response to receipt of the one-time password, provided via the unique link. During the second remote session, identification information of the second applicant is provided. A new multi-applicant account profile is then created, after verifying the identification information of the first applicant and the second applicant.

Abstract: An apparatus comprises a cache comprising a plurality of cache entries, and cache replacement control circuitry to select, in response to a cache request specifying a target address missing in the cache, a victim cache entry to be replaced with a new cache entry. The cache request specifies a partition identifier indicative of an execution environment associated with the cache request. The victim cache entry is selected based on re-reference interval prediction (RRIP) values for a candidate set of cache entries. The RRIP value for a given cache entry is indicative of a relative priority with which the given cache entry is to be selected as the victim cache entry. Configurable replacement policy configuration data is selected based on the partition identifier, and the RRIP value of the new cache entry is set to an initial value selected based on the selected configurable replacement policy configuration data.

Abstract: A semi-trailer including a cargo area, and an integrated fifth-wheel coupler unit extending horizontally along a front lower portion of the semi-trailer. The coupler unit includes an upper coupler surface defining a floor level of the cargo area, a lower coupler surface spaced below the upper coupler surface, and a kingpin projecting downwardly from the lower coupler surface and configured for coupling with a tow vehicle fifth wheel. A utility line connection portion is provided for establishing connections between at least one utility source of the tow vehicle and at least one utility component of the semi-trailer. The integrated fifth-wheel coupler unit includes a front wall with a recessed cavity at a central widthwise location accommodating the utility line connection portion.

Abstract: A blade for a turbine engine with a wall separating a cooling fluid flow and a hot gas fluid flow and having a heated surface along which the hot gas fluid flow flows and a cooled surface facing the cooling fluid flow. A plurality of cooling holes each having a passage extending between an inlet at the cooled surface and an outlet at the heated surface. The outlet extending between an upstream end and a downstream end with respect to the hot gas fluid flow to define a distance, the passage defining a centerline forming a first angle (?) with the heated surface.

Abstract: The disclosure provides methods and compositions useful for labeling of target molecules with origin-specific nucleic acid identifiers (for example, barcodes), which can be used subsequently to identify, quantify, or otherwise characterize a feature or activity of target molecules originating from a particular discreet volume. Such target molecules can include polypeptides expressed by cells, in which nucleic acid molecules encoding the polypeptides are labeled with the same, or matched, origin-specific nucleic acid identifiers.

Abstract: A patient interface, such as a nasal cannula is described. The patient interface has a body portion to be located, in-use upon a face of a user. The body portion has at least one side arm that extends laterally from a central bridge portion to be located about a user's septum region, where each side arm is connected to a resilient, or relatively more rigid, bridge portion element. The interface has at least one, and preferably a pair of, nasal prong(s). The body portion has at least one fluid passageway connected to the nasal prong(s) for supply of a gas to the nare(s) of the user's nose. A cross section of the passageway varies along the length of the body portion to regions of varying flexibility along the body portion. The bridge portion element defines a substantially predetermined spatial relationship for outlet(s) of a gas delivery system supplying gas via each side arm to the outlet(s) from which, for example, the nasal prong(s) may be provided in fluid connection.

Abstract: Systems, devices and methods including a handheld sensing device comprising: a sensor configured to measure ambient methane, ethane, propane, butane, and/or pentane concentrations; and a handle, where the sensor is disposed on a first end of the handle; control electronics comprising: a processor having addressable memory, the processor in communication with the sensor, where the processor is configured to: receive the measured ambient gas concentrations; and detect elevated ambient gas concentrations that may be attributed to a natural gas emissions source based on the measured ambient gas concentrations.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: Methods and systems for generating physiological metrics for display on a computing device are disclosed herein. In some implementations, an exemplary system comprises a torso wearable device including a wireless transmitter and a sensor, and non-transitory computer-readable media (CRM). The CRM, when executed by a computing device in communication with the wireless transmitter, can perform operations comprising: receiving the input signals representing respiration of the user; displaying a graphical user interface to the user; receiving one or more user inputs associated with a desired metric; displaying on the graphical user interface a first visualization corresponding to the desired metric; and displaying on the graphical user interface a second visualization corresponding to a physiological metric based on the input signals generated from the sensor. The second visualization can change in real time based on real time angular displacement of the sensor in response to the respiration of the user.

Abstract: A hybrid cable including: a jacket portion; a duct portion configured to be located inside the jacket portion; and an electrical conductor configured to be located inside the jacket portion. The electrical conductor is configured to be located outside of the duct portion; the electrical conductor and the duct portion extend substantially parallel to each other in the jacket portion; the duct portion is configured to be installed in the jacket portion in an empty state of the duct portion in which no wire or cable is in the duct portion; and the duct portion is configured to be loaded with fiber optic cable before, during, and after the hybrid cable is installed at an installation site so as to allow an installer to install an installation required number of fiber optic cables in the duct portion, thereby avoiding installation of unneeded fiber optic cable.

Abstract: The present invention generally relates to formulations comprising a drug and biodegradable polymers that are compacted mechanically from a physical mixture to disrupt interconnected open channels for substantially longer drug release than non-compacted counterpart formulations and methods of use and manufacture thereof.

Abstract: A sensor system for a turbomachine having an axis is disclosed. The sensor system includes a mounting member including a body configured to be mounted to a circumferential slot defined in at least a circumferential portion of a circumferential interior surface of a casing of the turbomachine. A plurality of sensors is coupled to the mounting member and configured to measure an operational parameter of the turbomachine.

Abstract: A folding pushcart, comprising a foldable cart body frame and a storage bag. The two sides of the body frame are hinged by two groups of first slanting rods and second slanting rods intersecting in the middle. The first diagonal rods in the corresponding groups on both sides are bent from a rod, and the bent bottom rod section faces the front and rear ends. The bottom rod section is used to support and tighten the bottom of the storage bag. The front and rear facades and the middle of the cart body frame are hinged by three U-shaped columns, and support the upper edge of the storage bag, forming a whole structure that can be folded and unfolded.

Abstract: In some embodiments, the present invention provides for a computer system which includes at least the following components: a plurality of computing devices associated with a plurality of users associated with a plurality of users; where each computing device of the plurality of computing devices is configured to: electronically receive software which, when being executed, cause such computing device to display a plurality of instances of a specifically programmed graphical user interface (GUI); where each instance of the GUI is configured to display a real-time updatable meeting information representative of a direct electronic proximity-based communication between at least two computing devices associated with at least two users who desire to meet at a particular location to engage in a transaction of at least one good, at least one service, or both, whose marketable value lasts for a period of 30 seconds to 60 minutes.

Abstract: Techniques for automatically securing receptacles of a retailer via an electronic lock include receiving a user request to reserve a receptacle, selecting a suitable receptacle based on one or more conditions, some of which may be specified by the user, and transmitting an electronic locking signal to secure, and thereby reserve, the selected receptacle. An association between the reserved receptacle and the user is stored, and the user is electronically notified. Subsequently, an electronic signal indicative of the identification of the user (or of the user's agent) is locally received. Upon determination that the user is expected and associated with the reserved receptacle, the techniques include causing an electronic unlocking signal to be transmitted to the electronic lock, thereby unlocking the receptacle.

Abstract: A mixing funnel for mixing fluids is provided. In one embodiment, the mixing funnel includes a tray having a fluid inlet arranged to receive a primary fluid flow, and first and second fluid passages configured to receive primary fluid flow from the fluid inlet such that the flow is divided to flow along the first and second fluid passages. The first and second fluid passages can be arranged to direct the primary fluid flow to a mixing area. The tray can further include a fluid outlet arranged to receive the primary fluid flow from the mixing area and to deliver the fluid to a container.

Abstract: An image sensor may include an array of imaging pixels arranged in rows and columns. Each column of imaging pixels may include a respective plurality of column output lines. Each column output line may be coupled to a respective subset of the imaging pixels in that column of imaging pixels. Each plurality of column output lines for a given column may be coupled to readout circuitry. Each group of column output lines may share a single respective sample and hold circuit and a single respective analog-to-digital converter. Alternatively, each group of column output lines may have one sample and hold circuit per column output line and each group of column output lines may share a single respective analog-to-digital converter. Alternatively, each group of column output lines may have one sample and hold circuit per column output line and may have one analog-to-digital converter per column output line.