Abstract: A method for providing an adjustable video player is disclosed. The method includes providing, by an electronic device, a content item player for playback of a content item in a portion of a user interface (UI) of an application executed on the electronic device and receiving an indication of a gesture to minimize the content item player made by a user of the electronic device. The method further includes minimizing the content item player into a mini-player shown on the application UI without interrupting the playback of the content item in the content item player.

Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.

Abstract: A pack having a group of tobacco industry products wrapped in a laminate to form a bundle is disclosed. The pack has a base containing the bundle, and a lid mounted to the base for rotation between open and closed positions. The laminate has an outer layer having a first cut that defines an outer layer region bounded by said first cut and, an inner layer having a second cut that defines an inner layer region bounded by said second cut. The inner layer region lies within the outer layer region. A part of the outer layer region is attached to an inside surface of the lid such that, as the lid is rotated into its open position, the inner and outer layer regions are lifted causing the inner and outer layers to delaminate in a peripheral region between the first and second cuts and an opening to be created in the laminate.

Abstract: Embodiments of the present invention provide a method, system and computer program product for limiting client side data storage based upon client geolocation. In an embodiment of the invention, a method for the differentiated treatment of data at rest in a mobile device includes receiving in a cache manager a request to cache data in a cache of a mobile device. Also, a geolocation for the mobile device is retrieved contemporaneous with the receipt of the request. Thereafter, it is determined from the geolocation whether or not the mobile device is present within a restricted geographic zone. Finally, in response to determining that the mobile device is present within a restricted geographic zone, the cache manager is directed to cache the data in a cache in the mobile device. But, otherwise the cache manager is directed to cache the data in a cache disposed in the computer communications network.

Abstract: A patient-matched cutting block including a surface or point contact features adapted to at least partially conform to or reference a patient specific anatomy. The cutting block having guide slots configured for guiding the movement of cutting tools relative to the patient specific anatomy or features configured to mate to and guide standard cutting guides relative to patient specific anatomy in order to form plateau and eminence resections of the patient specific anatomy.

Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

Abstract: A three-dimensional printer includes a vessel containing a liquid in which a printed object can debind during fabrication. More generally, the vessel may contain any liquid medium selected to control or modify properties of a printed object during fabrication. For example, the liquid may also or instead impose a controlled thermal environment for the printed object, apply finishing materials to an exterior surface of the object, provide a component or catalyst for a reaction, or otherwise treat the printed object or control ambient conditions during printing.

Abstract: Support structures are used in certain additive fabrication processes to permit fabrication of a greater range of object geometries. For additive fabrication processes with materials that are subsequently sintered into a final part, an interface layer is fabricated between the object and support in order to inhibit bonding between adjacent surfaces of the support structure and the object during sintering. Interface layers suitable for manufacture with an additive manufacturing system may resist the formation of bonds between a support structure and an object during subsequent sintering processes.

Abstract: A patient-matched cutting block including a surface or point contact features adapted to at least partially conform to or reference a patient specific anatomy. The cutting block having guide slots configured for guiding the movement of cutting tools relative to the patient specific anatomy or features configured to mate to and guide standard cutting guides relative to patient specific anatomy in order to form plateau and eminence resections of the patient specific anatomy.

Abstract: In an aspect, multiple metallic base materials are mixed into a user-controlled multimetallic mixture and extruded into a net shape, which is thermally processed into a multimetallic and/or alloyed object. In another aspect, a superstructure is fabricated around an object, but physically isolated from the object, with a shape facilitating robotic handling of the superstructure, along with removal of powder from the object, after a three-dimensional printing process. In another aspect, a ceramic precursor is used to create a separable interface between a support structure and a sinterable object. More specifically, a sinterable structure is fabricated from a sinterable powder in an aqueous binder, and an interface layer is formed by depositing a ceramic precursor in a nonaqueous solution onto the sinterable structure. When the ceramic precursor is exposed to water in the aqueous binder, the ceramic can precipitate to form an unsinterable, ceramic interface layer between sinterable structures.

Abstract: A pack having a group of tobacco industry products wrapped in a laminate to form a bundle is disclosed. The pack has a base containing the bundle, and a lid mounted to the base for rotation between open and closed positions. The laminate has an outer layer having a first cut that defines an outer layer region bounded by said first cut and, an inner layer having a second cut that defines an inner layer region bounded by said second cut. The inner layer region lies within the outer layer region. A part of the outer layer region is attached to an inside surface of the lid such that, as the lid is rotated into to its open position, the inner and outer layer regions are lifted causing the inner and outer layers to delaminate in a peripheral region between the first and second cuts and an opening to be created in the laminate.

Abstract: A social graph may be modeled as a collection of claims. Each claim is associated with an author, an audience, and an assertion about a fact. Probabilistic information may be collected from various sources for a claim, enabling a social networking system to evaluate a truthfulness of the assertion made in the claim. User-declared profile information may be evaluated as claims. A user, entity, or application may make claims about any assertions made in the social networking system. Reputation scores may be determined for users based on evaluations of their historical assertions. Claims may be evaluated for truthfulness using a probabilistic prediction model using heuristics analysis, regression analysis, and machine learning methods. A claims-based profile of users may be provided to viewers based on the contexts in which the claims were made. Viewers may view claims made about users, such as the users' biographical information, contact information, expertise, and interests.

Abstract: Embodiments of the present invention provide a method, system and computer program product for limiting client side data storage based upon client geolocation. In an embodiment of the invention, a method for the differentiated treatment of data at rest in a mobile device includes receiving in a cache manager a request to cache data in a cache of a mobile device. Also, a geolocation for the mobile device is retrieved contemporaneous with the receipt of the request. Thereafter, it is determined from the geolocation whether or not the mobile device is present within a restricted geographic zone. Finally, in response to determining that the mobile device is present within a restricted geographic zone, the cache manager is directed to cache the data in a cache in the mobile device. But, otherwise the cache manager is directed to cache the data in a cache disposed in the computer communications network.

Abstract: Systems and methods to provide patient-specific cutting blocks that allow for bone resurfacing procedures, such as milling or burring, with simplified devices. A computer assisted surgical cutting block is produced having a surface region that matches with the surface region of a patient's bone to be altered. A cutting tool may be provided having a contoured bone mating surface and a contoured and patient-specific shaped cutting guide surface located in a plane above the bone mating surface. One or more channels are provided in the cutting block, and as the surgeon moves the cutting tool (a milling or burring, for example) in the channels, the tool cuts the bone both laterally along the surface of the bone and vertically into the bone according to the cutting guide surface and other preselected surface features of the cutting block.

Abstract: A sample analysis and medical data acquisition system for patient management includes a first user interface (UI) display module for displaying a medical chart page that includes selectable items associated with patient management. The first UI display module displays a set of medical delivery systems associated with a selectable medical delivery selection item, from which a medical delivery system is chosen. The system includes a second UI display module, in communication with the first UI display module, for displaying parameter fields for entry of operation data associated with the chosen medical delivery system. Medical data is captured from a patient by an analyzer configured to perform analysis of samples from the patient. The medical data is analyzed in accordance with entered operation data. The system includes an analysis display module, in communication with at least the first UI display module, for displaying sample analysis results.

Abstract: Support structures are used in certain additive fabrication processes to permit fabrication of a greater range of object geometries. For additive fabrication processes with materials that are subsequently sintered into a final part, an interface layer is formed between the object and support in order to inhibit bonding between adjacent surfaces of the support structure and the object during sintering. The support structure may be a multi-part support structure to mitigate mold lock or facilitate removal from enclosed spaces.

Abstract: Techniques are disclosed for fabricating multi-part assemblies. In particular, by forming release layers between features such as bearings or gear teeth, complex mechanical assemblies can be fabricated in a single additive manufacturing process.

Abstract: Patient-matched surgical instruments and associated methods having an anatomy facing side including several discrete, physically separate anatomy contacting portions configured to match the anatomy of a particular patient and including one or more of non-uniform in distribution, non-uniform in shape and non-uniform in surface area.

Abstract: Devices, systems, and methods are directed to binder jetting for forming three-dimensional parts having controlled, macroscopically inhomogeneous material composition. In general, a binder may be delivered to each layer of a plurality of layers of a powder of inorganic particles. An active component may be introduced, in a spatially controlled distribution, to at least one of the plurality of layers such that the binder, the powder of inorganic particles, and the active component, in combination, form an object. The object may be thermally processed into a three-dimensional part having a gradient of one or more physicochemical properties of a material at least partially formed from thermally processing the inorganic particles and the active component of the object.

Abstract: A wearable device described herein includes a housing and a mount configured to mount the housing to an external surface of a wearer. The wearable device further includes one or more sensors configured to measure at least one physiological parameter of the wearer. The wearable device may obtain an activity metric that is based on at least one physiological parameter of the wearer measured by the one or more sensors and demographical data specific to the wearer. In some examples, the wearable may be configured to calculate the activity metric or a preliminary activity metric and to indicate the activity metric and/or preliminary activity metric to the wearer. In some examples, the wearable device may transmit the physiological parameter measurement to an external device and receive an indication of the activity metric from the external device.