Abstract: Techniques and compositions are disclosed for composite feedstocks with powder/binder systems suitable for three-dimensional printing, such as fused filament fabrication. The composite feedstocks may include a jacket about a core, with at least the core including a powder material suspended in a binder system and the jacket having a hardness or toughness greater than a hardness or toughness of the core for the feedstock. In general, the harder jacket may protect the core from unintended deformation or damage during transportation, storage, or use. For example, the difference in hardness or toughness between the jacket and the core may facilitate gripping the feedstock (e.g., by gear drives or the like) with a higher amount of force than is otherwise applicable if the feedstock were composed of the core alone, without damaging the core, during a fused filament fabrication process or another additive manufacturing process.

Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.

Abstract: A variety of additive manufacturing techniques can be adapted to fabricate a substantially net shape object from a computerized model using materials that can be debound and sintered into a fully dense metallic part or the like. However, during sintering, the net shape will shrink as binder escapes and the base material fuses into a dense final part. If the foundation beneath the object does not shrink in a corresponding fashion, the resulting stresses throughout the object can lead to fracturing, warping, or other physical damage to the object resulting in a failed fabrication. To address this issue, a variety of techniques are disclosed for substrates and build plates that contract in a manner complementary to the object during debinding and sintering.

Abstract: One embodiment illustrated herein includes a system for simulating communications in an environment. The system includes a postulated physical environment model, having modeled terrain and continuous changes over time. A channel parameter calculator is coupled to the postulated physical environment model, and configured to obtain samples from the postulated physical environment model, each sample comprising information about modeled terrain at a given time. The channel parameter calculator is further configured to, from the obtained samples, generate communication channel parameters, over time. A channel simulator is coupled to the channel parameter calculator. The channel simulator is configured to be coupled to signal source and to, using the communication channel parameters, apply the communication channel parameters to a communication signal from the signal source to simulate transmission of data through a simulated channel over time.

Abstract: A printer fabricates an object from a computerized model using a fused filament fabrication process. The shape of an extrusion nozzle may be varied during extrusion to control, e.g., an amount of build material deposited, a shape of extrudate exiting the nozzle, a feature resolution, and the like.

Abstract: A support structure is fabricated below a printed object to form a structure that prevents or minimizes a drag on a floor while the object shrinks during sintering.

Abstract: A printer fabricates an object from a computerized model using a fused filament fabrication process. A former extending from a nozzle of the printer supplements a layer fusion process by applying a normal force on new material as it is deposited to form the object. The former may use a variety of techniques such as heat and rolling to improve physical bonding between layers.

Abstract: A printer fabricates an object from a computerized model using a fused filament fabrication process. The shape of an extrusion nozzle may be varied during extrusion to control, e.g., an amount of build material deposited, a shape of extrudate exiting the nozzle, a feature resolution, and the like.

Abstract: An infiltratable material forms a net shape containing a porous network that can be infiltrated with a supplemental material, commonly referred to as an infiltrant, e.g., by heating the infiltrant so that it melts and wicks into the porous network of the net shape. By using additive fabrication technologies to spatially dispose an infiltrant about an infiltratable structure, a composite structure can be created that advantageously controls the amount of infiltrant applied to the infiltratable structure and the spatial distribution of the infiltrant about and/or within the infiltratable structure prior to infiltration.

Abstract: Multiple metallic base materials are mixed into a user-controlled multimetallic mixture and extruded into a net shape according to a digital model. The net shape can then be thermally processed into a multimetallic and/or alloyed object.

Abstract: A support structure is fabricated below a printed object to form a structure that prevents or minimizes a drag on a floor while the object shrinks during sintering.

Abstract: The devices, systems, and methods of the present disclosure are directed to spreading powder to facilitate accurate layer-by-layer fabrication of three-dimensional objects formed through binder jetting. More specifically, a spreader may be moved across a volume defined by a powder box to spread the powder in a layer. As the spreader is moved across the volume, the spreader may vibrate to pack the powder in the volume. By applying this vibration to the powder on a layer-by-layer basis, the resulting three-dimensional object formed through the binder jetting process may have improved density. In turn, such improved density may be useful for forming the three-dimensional objects into finished parts meeting target density standards, which may be particularly useful in the fabrication of metal parts. Further, or instead, applying vibration to the powder may reduce the likelihood of layer-to-layer variations in the three-dimensional object, thus reducing the likelihood of defects in finished parts.

Abstract: A printer fabricates an object from a computerized model using a fused filament fabrication process. A former extending from a nozzle of the printer supplements a layer fusion process by applying a normal force on new material as it is deposited to form the object. The former may use a variety of techniques such as heat and rolling to improve physical bonding between layers.

Abstract: A printer fabricates an object from a computerized model using a fused filament fabrication process. The shape of an extrusion nozzle may be varied during extrusion to control, e.g., an amount of build material deposited, a shape of extrudate exiting the nozzle, a feature resolution, and the like.

Abstract: A superstructure is fabricated around an object, but physically isolated from the object, with a shape that facilitates robotic handling of the superstructure, along with removal of powder from the object, after a three-dimensional printing process such as binder jetting.

Abstract: A ceramic precursor is used to create a separable interface between a support structure and a sinterable object. More specifically, a sinterable structure can be fabricated from a build material including a sinterable powder in an aqueous binder, and an interface layer can be formed by depositing a ceramic precursor in a nonaqueous solution onto the sinterable structure. When the ceramic precursor is exposed to water in the aqueous binder of the build material, the ceramic can precipitate to form an unsinterable, ceramic interface layer between the sinterable structure and adjacent sinterable structures.

Abstract: A support structure is formed from a support material below a printed object that shrinks similarly to a build material of the printed object during processing in a furnace.

Abstract: A patient-matched cutting block including a surface or point contact features adapted to at least partially conform to or reference a patient specific anatomy. The cutting block having guide slots configured for guiding the movement of cutting tools relative to the patient specific anatomy or features configured to mate to and guide standard cutting guides relative to patient specific anatomy in order to form plateau and eminence resections of the patient specific anatomy.

Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.

Abstract: Devices, systems, and methods are directed to the use of nanoparticles for improving fabrication of three-dimensional objects formed through layer-by-layer delivery of an ink onto a powder of metal particles in a powder bed. More specifically, the ink may include a colloid of nanoparticles of an inorganic material (e.g., a metal) in a carrier, and the colloid may be destabilized along one or more sections of at least one layer. Destabilization of the colloid may aggregate the nanoparticles along at least one layer to facilitate, for example, formation of an interface layer useful for separating the three-dimensional objects from associated support structures. Further, or instead, the aggregated nanoparticles may be useful for hardening a given layer to facilitate uniform distribution of a subsequent layer on top of the given layer. Thus, more generally, aggregation of the nanoparticles along the powder be may be useful for improving quality of the three-dimensional objects being fabricated.