Abstract: An additive manufacturing method including depositing a first amount of metal powder on a print bed, the first amount metal powder forming a first layer, depositing a first binder component to the first layer in a first region, and depositing a second binder component to the first layer in a second region.

Abstract: The present invention relates to a shrinking interface composition that allows for the accommodation of sintering shrinkage between two or more areas or sections of a three-dimensionally printed part and/or support structures for the part. The interface composition, which can be in the form of an interface layer, is used to prevent the fusing of the sections, parts or support structures to each other.

Abstract: A vehicle warning system includes a wireless communicator and an electronic controller. The wireless communicator is configured to receive data related to an area surrounding a vehicle and a trailer being towed by the vehicle, the data representing points of interest on the vehicle and on the trailer. The electronic controller is configured to determine a travel path of a host vehicle different from the vehicle, and generate a warning signal upon determining that the travel path indicates entry of the host vehicle into the area.

Abstract: A variety of additive manufacturing techniques can be adapted to fabricate a substantially net shape object from a computerized model using materials that can be debound and sintered into a fully dense metallic part or the like. However, during sintering, the net shape will shrink as binder escapes and the base material fuses into a dense final part. If the foundation beneath the object does not shrink in a corresponding fashion, the resulting stresses throughout the object can lead to fracturing, warping or other physical damage to the object resulting in a failed fabrication. To address this issue, a variety of techniques are disclosed for substrates and build plates that contract in a manner complementary to the object during debinding and sintering.

Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.

Abstract: A patient-matched cutting block including a surface or point contact features adapted to at least partially conform to or reference a patient specific anatomy. The cutting block having guide slots configured for guiding the movement of cutting tools relative to the patient specific anatomy or features configured to mate to and guide standard cutting guides relative to patient specific anatomy in order to form plateau and eminence resections of the patient specific anatomy.

Abstract: A three-dimensional printer includes a vessel containing a liquid in which a printed object can debind during fabrication. More generally, the vessel may contain any liquid medium selected to control or modify properties of a printed object during fabrication. For example, the liquid may also or instead impose a controlled thermal environment for the printed object, apply finishing materials to an exterior surface of the object, provide a component or catalyst for a reaction, or otherwise treat the printed object or control ambient conditions during printing.

Abstract: Support structures are used in certain additive fabrication processes to permit fabrication of a greater range of object geometries. For additive fabrication processes with materials that are subsequently sintered into a final part, an interface layer is fabricated between the object and support in order to inhibit bonding between adjacent surfaces of the support structure and the object during sintering. Interface layers suitable for manufacture with an additive manufacturing system may resist the formation of bonds between a support structure and an object during subsequent sintering processes.

Abstract: A patient-matched cutting block including a surface or point contact features adapted to at least partially conform to or reference a patient specific anatomy. The cutting block having guide slots configured for guiding the movement of cutting tools relative to the patient specific anatomy or features configured to mate to and guide standard cutting guides relative to patient specific anatomy in order to form plateau and eminence resections of the patient specific anatomy.

Abstract: In an aspect, multiple metallic base materials are mixed into a user-controlled multimetallic mixture and extruded into a net shape, which is thermally processed into a multimetallic and/or alloyed object. In another aspect, a superstructure is fabricated around an object, but physically isolated from the object, with a shape facilitating robotic handling of the superstructure, along with removal of powder from the object, after a three-dimensional printing process. In another aspect, a ceramic precursor is used to create a separable interface between a support structure and a sinterable object. More specifically, a sinterable structure is fabricated from a sinterable powder in an aqueous binder, and an interface layer is formed by depositing a ceramic precursor in a nonaqueous solution onto the sinterable structure. When the ceramic precursor is exposed to water in the aqueous binder, the ceramic can precipitate to form an unsinterable, ceramic interface layer between sinterable structures.

Abstract: Systems and methods to provide patient-specific cutting blocks that allow for bone resurfacing procedures, such as milling or burring, with simplified devices. A computer assisted surgical cutting block is produced having a surface region that matches with the surface region of a patient's bone to be altered. A cutting tool may be provided having a contoured bone mating surface and a contoured and patient-specific shaped cutting guide surface located in a plane above the bone mating surface. One or more channels are provided in the cutting block, and as the surgeon moves the cutting tool (a milling or burring, for example) in the channels, the tool cuts the bone both laterally along the surface of the bone and vertically into the bone according to the cutting guide surface and other preselected surface features of the cutting block.

Abstract: A sample analysis and medical data acquisition system for patient management includes a first user interface (UI) display module for displaying a medical chart page that includes selectable items associated with patient management. The first UI display module displays a set of medical delivery systems associated with a selectable medical delivery selection item, from which a medical delivery system is chosen. The system includes a second UI display module, in communication with the first UI display module, for displaying parameter fields for entry of operation data associated with the chosen medical delivery system. Medical data is captured from a patient by an analyzer configured to perform analysis of samples from the patient. The medical data is analyzed in accordance with entered operation data. The system includes an analysis display module, in communication with at least the first UI display module, for displaying sample analysis results.

Abstract: Support structures are used in certain additive fabrication processes to permit fabrication of a greater range of object geometries. For additive fabrication processes with materials that are subsequently sintered into a final part, an interface layer is formed between the object and support in order to inhibit bonding between adjacent surfaces of the support structure and the object during sintering. The support structure may be a multi-part support structure to mitigate mold lock or facilitate removal from enclosed spaces.

Abstract: Techniques are disclosed for fabricating multi-part assemblies. In particular, by forming release layers between features such as bearings or gear teeth, complex mechanical assemblies can be fabricated in a single additive manufacturing process.

Abstract: Patient-matched surgical instruments and associated methods having an anatomy facing side including several discrete, physically separate anatomy contacting portions configured to match the anatomy of a particular patient and including one or more of non-uniform in distribution, non-uniform in shape and non-uniform in surface area.

Abstract: Devices, systems, and methods are directed to binder jetting for forming three-dimensional parts having controlled, macroscopically inhomogeneous material composition. In general, a binder may be delivered to each layer of a plurality of layers of a powder of inorganic particles. An active component may be introduced, in a spatially controlled distribution, to at least one of the plurality of layers such that the binder, the powder of inorganic particles, and the active component, in combination, form an object. The object may be thermally processed into a three-dimensional part having a gradient of one or more physicochemical properties of a material at least partially formed from thermally processing the inorganic particles and the active component of the object.

Abstract: A wearable device described herein includes a housing and a mount configured to mount the housing to an external surface of a wearer. The wearable device further includes one or more sensors configured to measure at least one physiological parameter of the wearer. The wearable device may obtain an activity metric that is based on at least one physiological parameter of the wearer measured by the one or more sensors and demographical data specific to the wearer. In some examples, the wearable may be configured to calculate the activity metric or a preliminary activity metric and to indicate the activity metric and/or preliminary activity metric to the wearer. In some examples, the wearable device may transmit the physiological parameter measurement to an external device and receive an indication of the activity metric from the external device.

Abstract: A vehicle monitoring system includes an electronic controller and a wireless communicator. The electronic controller is configured to receive data representing points of interest on a vehicle and on a trailer towed by the vehicle, determine geometric relationships between the points of interest based on the data, and calculate an area surrounding the vehicle and the trailer based on the geometric relationships. The wireless communicator is operatively connected to the electronic controller and is configured to receive or transmit one of the data representing the points of interest, and the area based on the geometric relationships.

Abstract: A vehicle warning system includes a wireless communicator and an electronic controller. The wireless communicator is configured to receive data related to an area surrounding a vehicle and a trailer being towed by the vehicle, the data representing points of interest on the vehicle and on the trailer. The electronic controller is configured to determine a travel path of a host vehicle different from the vehicle, and generate a warning signal upon determining that the travel path indicates entry of the host vehicle into the area.

Abstract: A printer fabricates an object from a computerized model using a fused filament fabrication process. The shape of an extrusion nozzle may be varied during extrusion to control, e.g., an amount of build material deposited, a shape of extrudate exiting the nozzle, a feature resolution, and the like.