Abstract: A method and apparatus of operating an autonomous underwater vehicle (AUV) may include receiving an AUV in a receptacle of a submersible station. The AUV and the submersible station may be launched to an underwater location. The AUV may engage with the submersible station before, after or during a mission, and may return to the same or a different submersible station after part, or all, of the mission has been completed.

Abstract: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.

Abstract: A method of transmitting data acoustically through a tubular structure, such as a drill string or production tubing in an oil or gas well, predominantly comprising a series of tubing sections (1)joined end to end by couplings (2), at least a preponderance of the tubing sections having an axial length of at least a dimension X between couplings and at least a preponderance of the couplings having an axial length of no more than a dimension x, where X is substantially greater than x. The method comprises propagating acoustic signals along the structure, between transducers (9,10) over a distance N of at least 10X, in the form of tone bursts at least predominantly comprising a selected guided wave mode (preferably the L(0, 1) mode at low frequency) with a wavelength of at least 2x, and each burst having a temporal length of substantially less than 2N/C and preferably no more than 2X/C, where C is the phase velocity of the selected mode.

Abstract: A strain-responsive visual indicator comprises a pair of overlapping shutter strips (1, 2) adapted to be mounted to a substrate such that strain in the substrate causes relative movement M between them. Each shutter strip comprises an alternating set of windows (5) or (6) and bars (7) or (8) and the distal strip (2) is backed by a strip (3) of a different colour exposed through its windows (6), or the distal strip can instead be printed with a set of alternating colours in place of its windows and bars. The effect is that under different strain conditions different colour indications from the distal strip (2) will be visible through the windows (5) of the proximal strip (1), in accordance with the relative positions of the two strips. The indicator can be incorporated e.g. in the shaft of a toothbrush to give a visual warning in response to flexure of the shaft if excessive brushing pressure is applied. Numerous other applications and the use of different types of indicia are indicated in the specification.

Abstract: The invention provides criteria and methods for selecting optimum subsequence(s) from a target gene for targeting by a zinc finger protein. Some of the methods of target site selection seek to identify one or more target segments having a DNA motif containing one or more so-called D-able subsites having the sequence 5?NNGK3?. Other methods of the invention are directed to selection of target segments within target genes using a correspondence regime between different triplets of three bases and the three possible positions of a triplet within a nine-base site. In another aspect, the invention provides methods of designing zinc finger proteins that bind to a preselected target site. These methods can be used following the preselection of target sites according to the procedures and criteria described above. The methods of design use a database containing information about previously characterized zinc finger proteins.

Abstract: Disclosed herein are modified plant zinc finger proteins; compositions comprising modified plant zinc finger proteins and methods of making and using modified plant zinc finger proteins. The modified plant zinc finger proteins, in contrast to naturally-occurring plant zinc finger proteins, have a binding specificity that is determined by tandem arrays of modular zinc finger binding units.

Abstract: Disclosed herein are modified plant zinc finger proteins; compositions comprising modified plant zinc finger proteins and methods of making and using modified plant zinc finger proteins. The modified plant zinc finger proteins, in contrast to naturally-occurring plant zinc finger proteins, have a binding specificity that is determined by tandem arrays of modular zinc finger binding units.

Abstract: A system for the authentication by a card-issuing financial institution of identifying information of a card-holding user of a public data network. The system includes a secure data entry device connected to the public data network and a gateway device connected to the public data network and to a private data network used for transmitting messages between financial institutions wherein. The secure data entry device enables the user to enter identifying information of a card issued by the card-issuing financial institution, and means for transmitting transmits the identifying information in a secure manner over the public data network to the gateway device. The gateway device transmits the identifying information to the card-issuing financial institution and receives an approval response from the card-issuing financial institution over the private data network. The approval response provides authentication of the identifying information by the card-issuing financial institution.

Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.

Abstract: Disclosed herein are modified plant zinc finger proteins; compositions comprising modified plant zinc finger proteins and methods of making and using modified plant zinc finger proteins. The modified plant zinc finger proteins, in contrast to naturally-occurring plant zinc finger proteins, have a binding specificity that is determined by tandem arrays of modular zinc finger binding unit.

Abstract: A keypad is disclosed which has a plurality of keys (12) for the input of information. Each key has a first switch (80) and a second switch (90). The first switches (80) are all connected to a common electrical interconnection (120) and the second switches (90) are connected into a matrix electrical interconnection (62, 100). The microprocessor (66) detects a global signal on the common interconnection (120) and supplies scan signals to the matrix interconnection (62, 100) to enable detection of a particular key. The processor (66) may also selectively change the state of lines (62, 100) of the matrix and also maintain particular lines in a predetermined state by open drain ports of the processor to which the lines of the matrix are connected.

Abstract: The invention provides criteria and methods for selecting optimum subsequence(s) from a target gene for targeting by a zinc finger protein. Some of the methods of target site selection seek to identify one or more target segments having a DNA motif containing one or more so-called D-able subsites having the sequence 5?NNGK3?. Other methods of the invention are directed to selection of target segments within target genes using a correspondence regime between different triplets of three bases and the three possible positions of a triplet within a nine-base site. In another aspect, the invention provides methods of designing zinc finger proteins that bind to a preselected target site. These methods can be used following the preselection of target sites according to the procedures and criteria described above. The methods of design use a database containing information about previously characterized zinc finger proteins.

Abstract: Disclosed herein are modified plant zinc finger proteins; compositions comprising modified plant zinc finger proteins and methods of making and using modified plant zinc finger proteins. The modified plant zinc finger proteins, in contrast to naturally-occurring plant zinc finger proteins, have a binding specificity that is determined by tandem arrays of modular zinc finger binding unit.

Abstract: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.

Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.

Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.

Abstract: This invention relates to a new and distinct variety of strawberry (Fragaria xananassa) named ‘Wendy’. The invention is an early season, short-day variety similar to ‘Evangeline’. ‘Wendy’ is distinguished from ‘Evangeline’ by its flower characteristics, calyx characteristics, fruit size, fruit shape, and insertion of the achenes.

Abstract: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.

Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.

Abstract: This invention relates to a new and distinct variety of strawberry (Fragaria xananassa) named ‘Wendy’. The invention is an early season, short-day variety similar to ‘Evangeline’. ‘Wendy’ is distinguished from ‘Evangeline’ by its flower characteristics, calyx characteristics, fruit size, fruit shape, and insertion of the achenes.