Abstract: Stair system for outdoor building structures, such as decks are described. The stair system can include one or more perimeter frame members, one or more stair tread brackets; one or more stair tread members, and one or more fastening brackets coupled to the perimeter frame members, when in an assembled configuration.

Abstract: A cyclone filter includes a body including a cylindrical surface extending between a first end and a second end, and defining a cavity of the cyclone filter. An air inlet is formed through the cylindrical surface and is configured to receive airflow from a laundry cabinet and to direct the airflow along the cylindrical surface within the cavity. A vortex diverter extends within the cavity from the second end and is configured to interrupt airflow as it passes within the cavity between the diverter and the cylindrical surface to separate particulates from the airflow. A particulate outlet formed through the cylindrical surface and axially spaced from the air inlet is configured to direct particulates separated from the airflow toward a particulate receptacle.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: An imaging endoscopy system is disclosed, having a base unit, a hand controller, an umbilical section releasably connecting the base unit and the hand controller and an insertion section. The insertion section has a proximal end connected to the hand controller and a distal end for insertion into a subject, the distal end having a steering section and a distal tip. The hand controller includes at least one steering control for controlling bending of the steering section, and wherein the distal tip includes a light source for illumination of a region of tissue of interest and an imaging chip for imaging the region of tissue of interest. The hand controller, umbilical section and insertion section are single use disposable. The base unit is configured to be re-usable.

Abstract: Crystalline forms of 4-acetoxy-N,N-dimethyltryptamine (psilacetin), compositions containing that crystalline form, and their methods of use are disclosed. The crystalline forms of 4-acetoxy-N,N-dimethyltryptamine (psilacetin) according to the disclosure include crystalline 4-acetoxy-N,N-dimethyltryptammonium hydrofumarate, the fumarate salt of psilacetin, and/or crystalline bis(4-acetoxy-N,N-dimethyltryptammonium) fumarate, and pharmaceutical compositions containing a crystalline form of psilacetin.

Abstract: A tripod with a set of leg position control assemblies configured to enable deployment of each leg of the tripod into a predefined leg position is provided.

Abstract: Multimers are provided in which a Major Histocompatibility Complex (MHC) class I or class II molecule, optionally complexed with an MHC-binding peptide, is attached to a multimerization moiety from immunoglobulin M or A (IgM or IgA) to thereby create a multivalent peptide-MHC-Ig multimer composition. The multimers can be used, for example, to determine the binding specificity of T cell receptors, such as for particular MHC-peptide complexes. The multimers can also be used, for example, to modulate an immune response in a subject by administering the multimer to the subject. Methods of making the peptide-MHC-Ig multimers are also provided.

Abstract: An additive manufacturing system includes an additive manufacturing apparatus and control circuitry. The apparatus includes a build chamber, a platform, a material delivery system, a laser system, and a contaminant remover. The platform is positioned in the build chamber and is configured to support one or more objects being manufactured. The material delivery system is configured to provide feedstock material to the build chamber. The laser system is configured to melt the feedstock material to form the one or more objects being manufactured. The contaminant remover is configured to remove contaminants from a top layer of the one or more objects being manufactured prior to the material delivery system depositing a layer of the feedstock material thereon. The control circuitry is configured to control at least a portion of operation of the additive manufacturing apparatus. Contaminants may be removed from an object during manufacture of the object with the system.

Abstract: The present invention relates to specific binding molecules, such as T cell receptors (TCRs), that bind the HLA-A*02 restricted peptide KVLEYVIKV (SEQ ID NO: 1) derived from the germline cancer antigen MAGEA1. The specific binding molecules may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native MAGEA1 TCR. The specific binding molecules of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.

Abstract: A head-mounted device may include optical assemblies for presenting images to a user. The optical assemblies may each have a display for generating an image and a lens that presents the image to a corresponding eye box for viewing by a user. The optical assemblies may have lens barrels. Each lens barrel may have a first end to which a display is mounted and may have an opposing second end. A mount may be used to attach the lens to the second end of the lens barrel. The mount may have at least one flexure. The flexure may have a U-shaped cross-sectional shape. The mount may have a ring-shaped flexure that extends around a peripheral edge of the lens, may have flexure segments, or may have a set of three discrete flexures located at different positions along the edge of the lens.

Abstract: Aspects of the present disclosure relate to wellbore plugs, and specifically to pump down wiper plug assemblies used for conducting casing integrity pressure tests and completing wellbores. A plug assembly comprises one or more of a mandrel, a wiper, a dissolvable member, a rupture disk, and a movable sleeve. The dissolvable member and the rupture disk are configured to temporarily close fluid flow through an inner bore of the mandrel. The entire or only a portion of the outer surface of the dissolvable member comprises a protective coating.

Abstract: Disclosed are example embodiments of systems and methods for finding and storing connection paths between Internet connected devices, the system including at least one processor and at least one memory device. At least one memory device including instructions that, when executed by the at least one processor, cause the system to determine network locality, find a domain name system (DNS) record for a DNS authority nearest to a client, discover information for a cloud infrastructure for the DNS authority nearest to the client, and store the information in a database.

Abstract: Provided herein are anti-Ly6G6D (lymphocyte antigen 6 complex, locus G61) antibodies and methods of using the same.

Abstract: A linear actuator for axially translating a control tube to change the pitch of rotor blades at a top portion of the control tube, the linear actuator including an outer sleeve fixed in a stationary position with the control tube extending through the outer sleeve, a screw nut connected by a threaded interface to the control tube, and an actuator motor coupled to the screw nut to rotate the screw nut and thereby translate the control tube.

Abstract: This disclosure provides resin formulations which may be used for 3D printing and thermally treating to produce a ceramic material. The disclosure provides direct, free-form 3D printing of a preceramic polymer, followed by converting the preceramic polymer to a 3D-printed ceramic composite with potentially complex 3D shapes. A wide variety of chemical compositions is disclosed, and several experimental examples are included to demonstrate reduction to practice. For example, preceramic resin formulations may contain a carbosilane in which there is at least one functional group selected from vinyl, allyl, ethynyl, unsubstituted or substituted alkyl, ester group, amine, hydroxyl, vinyl ether, vinyl ester, glycidyl, glycidyl ether, vinyl glycidyl ether, vinyl amide, vinyl triazine, vinyl isocyanurate, acrylate, methacrylate, alkyl acrylate, alkyl methacrylate, phenyl, halide, thiol, cyano, cyanate, or thiocyanate.

Abstract: A folding trailing arm landing gear assembly having a main fitting configured to couple to a hinge positioned at a proximal end; a swing arm rotatably coupled at a proximal end to a distal end of the main fitting; a shock coupled at a distal end to a distal end of the swing arm; a bellcrank coupled at a distal end to a proximal end of the shock, and coupled at a proximal end to the main fitting; and a wheel coupled to the swing arm.

Abstract: Stiffened composite skin and methods of manufacture. A dry, hat-shaped preform is applied into a recess in a lower mold tool. A first set of dry, skin-preform layers is applied over the dry, hat-shaped preform to form a dry preform assembly. Resin is infused into the dry preform assembly to form a resin-infused preform. The resin-infused preform is cured in situ to form the stiffened composite skin.

Abstract: A flexible or rigid fluid-carrying conduit system has an inner conduit, an outer member, and a space between the inner conduit and outer member, the space including an insulator. Each of the outer surface of the inner conduit and the inner surface of the outer member is electrically conductive. These electrically conductive surfaces are used for detection of moisture in the fluid-carrying conduit by providing either an electrical circuit or a capacitance measuring device. Completion of the electrical circuit provides an indication that moisture has entered the space between the inner conduit and outer member so that remedial action can be taken. Measuring the capacitance between the inner conduit and the outer member also allows for monitoring moisture in this space. The capacitance measuring function can also be used to monitor changes in thermal resistance of the conduit. The fluid-carrying conduit have a liner, bulk insulation, and a vapor barrier.

Abstract: A child stroller apparatus includes a rear and a front leg frame respectively having a first and a second side segment, a handle frame having a grip portion and a third side segment respectively connected fixedly with a first and a second joining part that are pivotally connected with each other, a latching mechanism for locking the rear and front leg frames and the handle frame in an unfolded state, and a latch carried with the third side segment. The latch can engage and disengage the first joining part to lock and unlock the grip portion relative to the third side segment. Moreover, a linking part couples the latch to the rear leg frame or the front leg frame so that a folding rotation of the handle frame relative to the rear leg frame causes the latch to disengage from the first joining part.