Abstract: A pallet comprising: (a) a base tray having one or more walls extending upward from the tray to create a perimeter around a central portion of the base tray; (b) an insert disposed on the central portion of the tray within the perimeter of the base tray, the insert being recessed from a terminal edge of the one or more walls; (c) a post secured within the perimeter of the tray and extend away from the base tray; and (d) a support assembly secured to the insert and positioned along the central portion of the base tray free of contact with the one or more walls, wherein the support includes a pair of support panels that are interconnected and secured to the insert free of an adhesive.

Abstract: An electrical assembly which has a multi-layer conformal coating on at least one surface of the electrical assembly, wherein each layer of the multi-layer coating is obtainable by plasma deposition of a precursor mixture comprising (a) one or more organosilicon compounds, (b) optionally 02, N2O, NO2, H2, NH3, N2, SiF4 and/or hexafluoropropylene (HFP), and (c) optionally He, Ar and/or Kr. The chemistry of the resulting plasma-deposited material chemistry can be described by the general formula: SiOxHyCzFaNb. The properties of the conformal coating are tailored by tuning the values of x, y, z, a and b.

Abstract: The present invention relates to a medicament for treating neuropsychiatric diseases, comprising a compound of Formula (1): or a pharmaceutically acceptable salt thereof, as an active ingredient.

Abstract: In various examples, one or more logical interfaces are used to represent functional requirements of an architecture specification. The logical interfaces may indicate one or more dependencies of functionalities associated with a plurality of components of the architecture. Using the logical interfaces, one or more physical interfaces between the components may be recursively determined and used to perform an operation using the plurality of components.

Abstract: An electrical assembly which comprises a substrate and a conformal coating deposited on at least one surface of the substrate by plasma polymerization of a compound of formula (I) and deposition of a resulting polymer of the compound of formula (I), and plasma polymerization of a fluorohydrocarbon and deposition of a resulting polymer of the fluorohydrocarbon, such that the resulting polymer of the compound of formula (I) and the resulting polymer of the fluorohydrocarbon create discrete layers of the conformal coating; wherein the compound of formula (I) is an organic compound.

Abstract: The present invention relates to a medicament for treating neuropsychiatric diseases, comprising a compound of Formula (1): or a pharmaceutically acceptable salt thereof, as an active ingredient.

Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: Among other things, the present disclosure provides technologies for modulating complement activation. In some embodiments, the present disclosure provides compounds that inhibit C3 convertase activity. In some embodiments, the present disclosure provides methods for treating complement-mediated conditions, disorders or diseases. In some embodiments, the present disclosure provides methods for treating conditions, disorders or diseases mediated by C3 convertase.

Abstract: The present invention relates to compounds and pharmaceutically acceptable salts or solvates thereof for use in the treatment or prevention of fascioliasis. Some of these compounds are novel per se and also have activity as inhibitors of Schistosoma growth. The invention also relates to pharmaceutical compositions comprising such novel compounds, salts or solvates and to the use of such novel compounds as medicaments, in particular in the treatment or prevention of schistosomiasis, also known as bilharzia.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: A tool (1) for a tool holder (3) of a blister packing machine. The tool (1) comprises a body member (25) extending from a proximal front end (30) to a distal rear end (32) and defines a major engagement face (27) for abutting a corresponding abutment face (5) of the tool holder (3), and an opposite major working face (29) which acts on the material to be worked on by the tool (1). An elongated alignment member (35) extending from a proximal end (40) to a distal end (42) extends centrally along the body member (25) from a location adjacent the proximal end (30) of the body member (25) towards the distal end (32). The alignment member (35) is of T-shaped transverse cross-section having a central member (37) and a pair of side flanges (39) extending from the central member (37) for slideably engaging a corresponding T-shaped receiving groove (10) in the tool holder (3).

Abstract: The invention relates to compounds of Formula (I): and related aspects.

Abstract: Detection and prevention of resource drain from unauthorized wireless device connections is provided. Responsive to receiving of a connection request from a connecting device, a pre-authentication message is sent to the connecting device, the pre-authentication message including a challenge value. A vehicle hash result is computed using a hash function taking the challenge value and the unique identifier of the vehicle as inputs. A device hash result is received from the connecting device. Responsive to a match of the vehicle hash result and the device hash result, additional hardware of the vehicle is activated to perform a secondary authentication of the connecting device. Responsive to a mismatch, authentication of the connecting device is rejected without activation of the additional hardware, thereby avoiding key-off load from the additional hardware in instances where pre-authentication of the connecting device fails.

Abstract: The invention provides a compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle; and R2 is an optionally substituted 5- or 6-membered aromatic heterocycle. Also provided are pharmaceutical compositions comprising a compound of formula (I).

Abstract: A method for depositing a protective coating onto a substrate, wherein the protective coating comprises (i) a moisture-barrier layer which is in contact with the substrate and which comprises a first sub-layer, optionally one or more intermediate sub-layers, and a final sub-layer, (ii) a mechanical-protective layer which is inorganic, and (iii) a gradient layer interposing the moisture-barrier layer and the mechanical-protective layer.

Abstract: It has surprisingly been discovered that it is possible to stabilize biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilize and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.

Abstract: A pallet comprising: (a) a base tray having one or more walls extending upward from the tray to create a perimeter around a central portion of the base tray; (b) an insert disposed on the central portion of the tray within the perimeter of the base tray, the insert being recessed from a terminal edge of the one or more walls; (c) a post secured within the perimeter of the tray and extend away from the base tray; and (d) a support assembly secured to the insert and positioned along the central portion of the base tray free of contact with the one or more walls, wherein the support includes a pair of support panels that are interconnected and secured to the insert free of an adhesive.

Abstract: The present invention provides compounds of formula I or II: wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: The invention provides a compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle; and R2 is an optionally substituted 5- or 6-membered aromatic heterocycle. Also provided are pharmaceutical compositions comprising a compound of formula (I).