Patents by Inventor Andrew Simon

Andrew Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11911564
    Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: February 27, 2024
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Matthew Jon Payton, Kevin Peter O'Donnell, Andrew Baden Clark, Christopher Simon James Quill, Peter Geoffrey Hawkins
  • Publication number: 20240050982
    Abstract: A method for depositing a protective coating onto a substrate, wherein the protective coating comprises (i) a moisture-barrier layer which is in contact with the substrate and which comprises a first sub-layer, optionally one or more intermediate sub-layers, and a final sub-layer, (ii) a mechanical-protective layer which is inorganic, and (iii) a gradient layer interposing the moisture-barrier layer and the mechanical-protective layer.
    Type: Application
    Filed: October 16, 2023
    Publication date: February 15, 2024
    Inventors: Shailendra Vikram Singh, Gianfranco Aresta, Andrew Simon Hall Brooks, Siobhan Marie Woollard, Gareth Hennighan
  • Publication number: 20240027309
    Abstract: It has surprisingly been discovered that it is possible to stabilize biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilize and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.
    Type: Application
    Filed: February 3, 2023
    Publication date: January 25, 2024
    Inventors: Andrew Simon Goldsborough, Malcom Robert Bates
  • Publication number: 20240017879
    Abstract: A pallet comprising: (a) a base tray having one or more walls extending upward from the tray to create a perimeter around a central portion of the base tray; (b) an insert disposed on the central portion of the tray within the perimeter of the base tray, the insert being recessed from a terminal edge of the one or more walls; (c) a post secured within the perimeter of the tray and extend away from the base tray; and (d) a support assembly secured to the insert and positioned along the central portion of the base tray free of contact with the one or more walls, wherein the support includes a pair of support panels that are interconnected and secured to the insert free of an adhesive.
    Type: Application
    Filed: July 27, 2023
    Publication date: January 18, 2024
    Inventors: Andrew Simons, Jeff Williams, Shane Wright, Rick T. Vulgamott, Aaron McDonald, Shannon Hoover
  • Publication number: 20230382911
    Abstract: The present invention provides compounds of formula I or II: wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: July 28, 2023
    Publication date: November 30, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Andrew Simon BELL, Jérémy BESNARD, Anthony Richard BRADLEY, Luke GREEN, Wolfgang HAAP, Buelent KOCER, Andreas KUGLSTATTER, Xavier LUCAS, Patrizio MATTEI, Dmitry MAZUNIN, Claus RIEMER, Willem Paul VAN HOORN
  • Patent number: 11786930
    Abstract: A method for depositing a protective coating onto a substrate, wherein the protective coating comprises (i) a moisture-barrier layer which is in contact with the substrate and which comprises a first sub-layer, optionally one or more intermediate sub-layers, and a final sub-layer, (ii) a mechanical-protective layer which is inorganic, and (iii) a gradient layer interposing the moisture-barrier layer and the mechanical-protective layer.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: October 17, 2023
    Inventors: Shailendra Vikram Singh, Gianfranco Aresta, Andrew Simon Hall Brooks, Siobhan Marie Woollard, Gareth Hennighan
  • Patent number: 11786528
    Abstract: The invention provides a compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle; and R2 is an optionally substituted 5- or 6-membered aromatic heterocycle. Also provided are pharmaceutical compositions comprising a compound of formula (I).
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: October 17, 2023
    Assignees: EXSCIENTIA LTD., EVOTEC INTERNATIONAL GMBH
    Inventors: Andrew Simon Bell, Adrian Michael Schreyer, Stephanie Versluys
  • Publication number: 20230286978
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: April 7, 2021
    Publication date: September 14, 2023
    Inventors: Jonathan Bentley, Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • Publication number: 20230271957
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: April 7, 2021
    Publication date: August 31, 2023
    Inventors: Jonathan Bentley, JR., Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • Patent number: 11719926
    Abstract: Provided herein is a modulating retroreflective multilayer film comprising retroreflective elements, a piezoelectric layer, a photovoltaic layer, and an energy storage device. The stacked and transparent layered configuration of the film allows the retroreflective elements and the photovoltaic layer to be simultaneously illuminated by a narrow beam. The low power piezoelectric layer and the energy harvesting of the photovoltaic layer allow the retroreflector to be energetically self-sufficient and suitable for remote deployment. The flexible properties of the component layers allow the retroreflector to be adhered to nonplanar or irregular surfaces for the purpose of labeling and tagging.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: August 8, 2023
    Inventor: Andrew Simon Filo
  • Patent number: 11713160
    Abstract: A pallet comprising: (a) a base tray having one or more walls extending upward from the tray to create a perimeter around a central portion of the base tray; (b) an insert disposed on the central portion of the tray within the perimeter of the base tray, the insert being recessed from a terminal edge of the one or more walls; (c) a post secured within the perimeter of the tray and extend away from the base tray; and (d) a support assembly secured to the insert and positioned along the central portion of the base tray free of contact with the one or more walls, wherein the support includes a pair of support panels that are interconnected and secured to the insert free of an adhesive.
    Type: Grant
    Filed: September 2, 2022
    Date of Patent: August 1, 2023
    Assignee: Multi Packaging Solutions, Inc.
    Inventors: Andrew Simons, Jeff Williams, Shane Wright, Rick T. Vulgamott, Aaron McDonald, Shannon Hoover
  • Publication number: 20230227449
    Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: December 19, 2022
    Publication date: July 20, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Andrew Simon Bell, Jérémy Besnard, Anthony Richard Bradley, Luke Green, Wolfgang Haap, Buelent Kocer, Andreas Kuglstatter, Xavier Lucas, Patrizio Mattei, Dmitry Mazunin, Hasane Ratni, Claus Riemer, Willem Paul Van Hoorn
  • Publication number: 20230219953
    Abstract: The present invention provides compounds of formula I wherein X1, X2, X3, X4, R1, R1a, R1b, R2?, R2?, R3?, R3?, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.
    Type: Application
    Filed: December 19, 2022
    Publication date: July 13, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Andrew Simon Bell, Jérémy Besnard, Anthony Richard Bradley, Luke Green, Wolfgang Haap, Buelent Kocer, Andreas Kuglstatter, Xavier Lucas, Patrizio Mattei, Dmitry Mazunin, Claus Riemer, Willem Paul Van Hoorn
  • Publication number: 20230220313
    Abstract: Provided is the use of a composition to inactive a virus. The composition comprises a quaternary ammonium compound and a halogenated organic compound. Also provided are a composition and kit for inactivating a virus, and a method for detecting an analyte in a sample.
    Type: Application
    Filed: April 12, 2021
    Publication date: July 13, 2023
    Inventors: Andrew Simon Goldsborough, Malcolm Robert Bates
  • Publication number: 20230126423
    Abstract: Methods of producing recombinant, multi-component proteins in eukaryotic expression systems, comprising co-transforming a eukaryotic cell with two or more different nucleic acid constructs, each comprising a respective transcriptional unit encoding a protein component, wherein each nucleic acid construct comprises the same promoter and signal sequence, such that each of the components will be targeted to the same organelle of the cell for expression and intracellular assembly. In one or more embodiments, each nucleic acid construct comprises a promoter from a protein storage gene that is operably linked to a DNA sequence that encodes for a protein storage-specific signal sequence.
    Type: Application
    Filed: March 2, 2021
    Publication date: April 27, 2023
    Inventors: Deshui Zhang, Andrew Simon, Derek Schneweis, Saurav Misra, Javier Herrera, Mark Lagrimini
  • Publication number: 20230050240
    Abstract: Configuration of signal strength calibration offset is provided. A user interface is displayed, to a screen of a mobile device, for configuration of a signal strength offset of a wireless transceiver to a vehicle, the signal strength offset being an offset with respect to a default calibration of signal strength measurements between the wireless transceiver and the vehicle, the signal strength calibration being for use in calibrating a location of the mobile device for a passive zone with respect to the vehicle. An update to the signal strength calibration is received from the user interface. The signal strength calibration as updated is sent to the vehicle for use in locating the mobile device for the passive zone.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 16, 2023
    Inventors: Michael Andrew SIMONS, Brian Y. WILKERSON, Yong KONG
  • Publication number: 20230008875
    Abstract: The present invention relates to a medicament for treating neuropsychiatric diseases, comprising a compound of Formula (1): or a pharmaceutically acceptable salt thereof, as an active ingredient.
    Type: Application
    Filed: August 17, 2022
    Publication date: January 12, 2023
    Applicant: Sumitomo Pharma Co., Ltd.
    Inventors: Hidefumi YOSHINAGA, Yohei IKUMA, Junya IKEDA, Satoshi ADACHI, Harunobu MITSUNUMA, Yoshinori AIHARA, Jeremy BESNARD, Andrew Simon BELL
  • Publication number: 20230008433
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: August 17, 2021
    Publication date: January 12, 2023
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Sophie Catherine COOPER, Rajesh DEVRAJ, Robert Owen HUGHES, Richard Andrew JARJES-PIKE, Frederic Jacques MARLIN, Shelley Anne PARROTT, Daniel SILVA
  • Publication number: 20220411431
    Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).
    Type: Application
    Filed: July 27, 2022
    Publication date: December 29, 2022
    Applicant: Imperial College Innovations Limited
    Inventors: Andrew Simon Bell, Edward William Tate, Robin John Leatherbarrow, Jennie Ann Hutton, James Antony Brannigan
  • Publication number: 20220345886
    Abstract: Detection and prevention of resource drain from unauthorized wireless device connections is provided. Responsive to receiving of a connection request from a connecting device, a pre-authentication message is sent to the connecting device, the pre-authentication message including a challenge value. A vehicle hash result is computed using a hash function taking the challenge value and the unique identifier of the vehicle as inputs. A device hash result is received from the connecting device. Responsive to a match of the vehicle hash result and the device hash result, additional hardware of the vehicle is activated to perform a secondary authentication of the connecting device. Responsive to a mismatch, authentication of the connecting device is rejected without activation of the additional hardware, thereby avoiding key-off load from the additional hardware in instances where pre-authentication of the connecting device fails.
    Type: Application
    Filed: April 22, 2021
    Publication date: October 27, 2022
    Inventors: Jochen SCHUBERT, Fouad BOUNEFISSA, Michael Andrew SIMONS, Thomas NELSON, Timothy THIVIERGE, Jr.