Abstract: The present invention relates to a medicament for treating neuropsychiatric diseases, comprising a compound of Formula (1): or a pharmaceutically acceptable salt thereof, as an active ingredient.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: Detection and prevention of resource drain from unauthorized wireless device connections is provided. Responsive to receiving of a connection request from a connecting device, a pre-authentication message is sent to the connecting device, the pre-authentication message including a challenge value. A vehicle hash result is computed using a hash function taking the challenge value and the unique identifier of the vehicle as inputs. A device hash result is received from the connecting device. Responsive to a match of the vehicle hash result and the device hash result, additional hardware of the vehicle is activated to perform a secondary authentication of the connecting device. Responsive to a mismatch, authentication of the connecting device is rejected without activation of the additional hardware, thereby avoiding key-off load from the additional hardware in instances where pre-authentication of the connecting device fails.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present invention relates to a medicament for treating neuropsychiatric diseases, comprising a compound of Formula (1): or a pharmaceutically acceptable salt thereof, as an active ingredient.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present invention relates to a compound represented by formula (1): the compound having antagonist activity against serotonin 5-HT2A receptors and serotonin 5-HT7 receptors; or a pharmaceutically acceptable salt of the compound. (In the formula, Z is a nitrogen atom and the like; Y is carbonyl and the like; m and n are 1 and the like; R1a through R1d, R2a through R2d, and R4a through R4d are a hydrogen atom and the like; R3 is alkyl and the like; and Q is a specific bicyclic group.

Abstract: A plasma processing apparatus for processing a substrate using a plasma, comprising: a process chamber in which the processing takes place; a plasma source for providing a plasma to the process chamber; a substrate mount within the process chamber for holding the substrate, the substrate mount comprising a surface having a plurality of apertures.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: The present disclosure relates to aspects of authenticating a mobile device and providing a vehicle access key thereto when a previously registered mobile device is not accessible. In one aspect of the present disclosure, a method includes requesting at a first mobile device, access to a profile associated with controlling operations of a vehicle, the profile having stored thereon an access key for operating the vehicle, the access key having been previously installed on a second mobile device. The method further includes upon successful authorization, receiving the access key at the first device and operating the vehicle using the access key on the first mobile device.

Abstract: The present invention relates to a compound represented by formula (1): the compound having antagonist activity against serotonin 5-HT2A receptors and serotonin 5-HT7 receptors; or a pharmaceutically acceptable salt of the compound. (In the formula, Z is a nitrogen atom and the like; Y is carbonyl and the like; m and n are 1 and the like; R1a through R1d, R2a through R2d, and R4a through R4d are a hydrogen atom and the like; R3 is alkyl and the like; and Q is a specific bicyclic group.

Abstract: The present invention relates to a compound represented by formula (1): the compound having antagonist activity against serotonin 5-HT2A receptors and serotonin 5-HT7 receptors; or a pharmaceutically acceptable salt of the compound. (In the formula, Z is a nitrogen atom and the like; Y is carbonyl and the like; m and n are 1 and the like; R1a through R1d, R2a through R2d, and R4a through R4d are a hydrogen atom and the like; R3 is alkyl and the like; and Q is a specific bicyclic group.

Abstract: The invention provides inter alia compound as defined herein and its use in the prevention or treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, e.g. cancer.

Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Abstract: An electrical assembly which comprises a substrate and a conformal coating deposited on at least one surface of the substrate by plasma polymerization of a compound of formula (I) and deposition of a resulting polymer of the compound of formula (I), and plasma polymerization of a fluorohydrocarbon and deposition of a resulting polymer of the fluorohydrocarbon, such that the resulting polymer of the compound of formula (I) and the resulting polymer of the fluorohydrocarbon create discrete layers of the conformal coating; wherein the compound of formula (I) is an organic compound.

Abstract: A random access memory array including a plurality of local memory group ways, each local memory group way including, a plurality of local memory groups, each local memory group including, a memory column including a plurality of memory cells, a pair of local bitlines operatively connected to the plurality of memory cells, and a local group periphery including a local bitline multiplexer operatively connected with the pairs of local bitlines of the corresponding local memory group; and a pair of global read bitlines operatively connected to outputs of the plurality of local group peripheries, a global read bitline multiplexer operatively connected to outputs of the plurality of pairs of the global read bitlines from the local memory group ways, and a bitline operational block operatively connected an output of the global read bitline multiplexer.

Abstract: A random access memory array including a plurality of local memory group ways, each local memory group way including, a plurality of local memory groups, each local memory group including, a memory column including a plurality of memory cells, a pair of local bitlines operatively connected to the plurality of memory cells, and a local group periphery including a local bitline multiplexer operatively connected with the pairs of local bitlines of the corresponding local memory group; and a pair of global read bitlines operatively connected to outputs of the plurality of local group peripheries, a global read bitline multiplexer operatively connected to outputs of the plurality of pairs of the global read bitlines from the local memory group ways, and a bitline operational block operatively connected an output of the global read bitline multiplexer.

Abstract: The present disclosure relates to aspects of authenticating a mobile device and providing a vehicle access key thereto when a previously registered mobile device is not accessible. In one aspect of the present disclosure, a method includes requesting at a first mobile device, access to a profile associated with controlling operations of a vehicle, the profile having stored thereon an access key for operating the vehicle, the access key having been previously installed on a second mobile device. The method further includes upon successful authorization, receiving the access key at the first device and operating the vehicle using the access key on the first mobile device.