Patents by Inventor Andrew Simon

Andrew Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors
    Publication number: 20180134696
    Abstract: The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of Alpha7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
    Type: Application
    Filed: June 9, 2016
    Publication date: May 17, 2018
    Inventors: Raksha Acharya, Duane A. Burnett, Matthew Gregory Bursavich, Andrew Simon Cook, Bryce Alden Harrison, Andrew J. McRiner
  • COMPOSITION FOR BONDING WINDINGS OR CORE LAMINATES IN AN ELECTRICAL MACHINE, AND ASSOCIATED METHOD
    Publication number: 20180127626
    Abstract: A curable composition for bonding windings or core laminates in an electrical machine is presented. The curable composition includes: (A) about 10 weight percent to about 25 weight percent of a polyfunctional cyanate ester; (B) about 35 weight percent to about 65 weight percent of a first difunctional cyanate ester, or a prepolymer thereof (C) about 15 weight percent to about 40 weight percent of a second difunctional cyanate ester, or a prepolymer thereof. An associated method is also presented.
    Type: Application
    Filed: January 8, 2018
    Publication date: May 10, 2018
    Inventors: Weijun Yin, Gary William Yeager, Kevin Warner Flanagan, David Andrew Simon, Eugene Pauling Boden, Kathryn Amanda Misner
  • Curable composition for electrical machine, and associated method
    Patent number: 9911521
    Abstract: A curable composition for an electrical machine is presented. The curable composition includes: (A) about 10 weight percent to about 30 weight percent of a polyfunctional cyanate ester; (B) about 25 weight percent to about 60 weight percent of a first difunctional cyanate ester, or a prepolymer thereof; (C) about 10 weight percent to about 30 weight percent of a second difunctional cyanate ester, or a prepolymer thereof, and (D) about 5 weight percent to about 25 weight percent of a thermally conductive filler comprising boron nitride. An associated method is also presented.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: March 6, 2018
    Assignee: General Electric Company
    Inventors: Eugene Pauling Boden, Kevin Warner Flanagan, David Andrew Simon, Weijun Yin, Wei Zhang, Robert Colin McTigue, Kathryn Amanda Misner, Gary William Yeager
  • SAMPLE FIXATION AND STABILISATION
    Publication number: 20180058988
    Abstract: It has surprisingly been discovered that it is possible to stabilise biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilise and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.
    Type: Application
    Filed: August 14, 2017
    Publication date: March 1, 2018
    Inventors: Andrew Simon Goldsborough, Malcolm Robert Bates
  • Composition for bonding windings or core laminates in an electrical machine, and associated method
    Patent number: 9879163
    Abstract: A curable composition for bonding windings or core laminates in an electrical machine is presented. The curable composition includes: (A) about 10 weight percent to about 25 weight percent of a polyfunctional cyanate ester; (B) about 35 weight percent to about 65 weight percent of a first difunctional cyanate ester, or a prepolymer thereof; (C) about 15 weight percent to about 40 weight percent of a second difunctional cyanate ester, or a prepolymer thereof. An associated method is also presented.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: January 30, 2018
    Assignee: General Electric Company
    Inventors: Weijun Yin, Gary William Yeager, Kevin Warner Flanagan, David Andrew Simon, Eugene Pauling Boden, Kathryn Amanda Misner
  • GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTONIC ACETYLCHOLINE RECEPTORS
    Publication number: 20170369486
    Abstract: The present invention relates to novel geminal substituted quinuclidine amide compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ?7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
    Type: Application
    Filed: December 14, 2015
    Publication date: December 28, 2017
    Applicant: AXOVANT SCIENCES GMBH
    Inventors: Raksha ACHARYA, Duane A. BURNETT, Matthew Gregory BURSAVICH, Andrew Simon COOK, Bryce Alden HARRISON, Gerhard KOENIG, Andrew J. MCRINER
  • Substituted Piperidine Compounds
    Publication number: 20170362217
    Abstract: The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
    Type: Application
    Filed: September 9, 2015
    Publication date: December 21, 2017
    Applicant: EPIZYME, INC.
    Inventors: Lorna Helen MITCHELL, Andrew Simon BELL, Richard CHESWORTH, Megan Alene Cloonan FOLEY, Kevin Wayne KUNTZ, James Edward John MILLS, Michael John MUNCHHOF
  • SAMPLE FIXATION AND STABILISATION
    Publication number: 20170328819
    Abstract: It has surprisingly been discovered that it is possible to stabilise biomolecules such as RNA, DNA and proteins in biological samples such as cells, tissues, biopsies and blood using deep eutectic solvents (DES). It has also been discovered that DES mixtures can be used to fix and preserve cell morphology in biological samples such as tissue blocks, cancer biopsies and whole blood. This invention describes methods to stabilise and preserve biomolecules, whole cells, tissues, blood and biological samples using DES mixtures.
    Type: Application
    Filed: May 30, 2017
    Publication date: November 16, 2017
    Inventors: Andrew Simon Goldsborough, Malcolm Robert Bates
  • Lucent waveguide plasma light source
    Patent number: 9818597
    Abstract: A lucent waveguide plasma light source has a quartz waveguide body with a central through bore. The bore has orifices at its opposite ends, opening centrally of flat, end faces of the body. Between these the body has a circular cylindrical periphery. A drawn quartz tube is inserted into the body. The tube has its one end closed and a collar which locates the tube in the bore and is fused to the faces at the orifices of the bore. The tube is evacuated and charged with excitable material and closed as a sealed void. A Faraday cage and an antenna in a bore in the body are provided for feeding microwave energy to the light source. When powered with microwaves, resonance is established in the wave guide and a plasma is established in the void, wherein Light radiates and leaves the waveguide and Faraday cage radially of the periphery.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: November 14, 2017
    Inventor: Andrew Simon Neate
  • Oxadiazine compounds and methods of use thereof
    Patent number: 9802927
    Abstract: The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: October 31, 2017
    Assignee: DENALI THERAPEUTICS, INC.
    Inventors: Raksha Acharya, Duane A. Burnett, Matthew Gregory Bursavich, Andrew Simon Cook, Bryce Alden Harrison, Andrew J. McRiner
  • Aminoisoxazoline Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors
    Publication number: 20170247393
    Abstract: The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ?7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
    Type: Application
    Filed: October 12, 2016
    Publication date: August 31, 2017
    Inventors: Raksha Acharya, Duane A. Burnett, Matthew Gregory Bursavich, Andrew Simon Cook, Bryce Alden Harrison, Andrew J. McRiner
  • Method of Making a Polymer Foam
    Publication number: 20170226306
    Abstract: In general, the present invention is directed to a continuous method of making a polymer foam by using a polymer having a first monomeric component and a second monomeric component. The method employs a tandem type extruder having a first extruder and a second extruder. The method disclosed herein can provide a foam having a desired cell size, cell density, porosity, foam density, and/or thermal conductivity, etc. In turn, the polymer foams produced according to the present method can have numerous applications, such as thermal insulation applications for appliances including ovens, freezers, refrigerators, etc.
    Type: Application
    Filed: February 9, 2016
    Publication date: August 10, 2017
    Inventors: Norberto Silvi, Donald Joseph Buckley, JR., David Andrew Simon, Davide Louis Simone, Joseph Anthony Pavlisko
  • Contact Lens Assessment
    Publication number: 20170196446
    Abstract: A method and apparatus (100) for processing an image to determine one or more parameters of a contact lens suitable for a human or animal subject. The image comprises a plurality of pixels forming an image of at least part of one eye of the subject. The apparatus comprises: an iris detector (116) configured to determine a diameter of an iris of the subject; a cornea determiner (118) configured to determine a diameter of a cornea of the subject based on the determined diameter of the iris; and a contact lens determiner (120) configured to determine one or more parameters of contact lens for the subject based on the determined cornea diameter.
    Type: Application
    Filed: May 22, 2015
    Publication date: July 13, 2017
    Applicant: IRISS Medical Technologies Limited
    Inventors: Yuval Yashiv, Ron Uriel Maor, Nigel Andrew Simon Barnard
  • Light Source
    Publication number: 20170125236
    Abstract: A light source to be powered by microwave energy, having a dielectric body or fabrication of material lucent for exit of light therefrom, a receptacle within the dielectric body or fabrication, and a lucent microwave-enclosing Faraday cage surrounding the dielectric body or fabrication. The dielectric body or fabrication within the Faraday cage forms at least part of a microwave resonant cavity. A sealed plasma enclosure of lucent material within the receptacle has a means for locating the plasma enclosure within the receptacle with respect to the dielectric body or fabrication.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 4, 2017
    Inventors: Andrew Simon Neate, Edward Charles Odell, John Stocks
  • COATED ELECTRICAL ASSEMBLY
    Publication number: 20170094810
    Abstract: An electrical assembly which has a multi-layer conformal coating on at least one surface of the electrical assembly, wherein each layer of the multi-layer coating is obtainable by plasma deposition of a precursor mixture comprising (a) one or more organosilicon compounds, (b) optionally O2, N2O, NO2, H2, NH3, N2, SiF4 and/or hexafluoropropylene (HFP), and (c) optionally He, Ar and/or Kr. The chemistry of the resulting plasma-deposited material chemistry can be described by the general formula: SiOxHyCzFaNb. The properties of the conformal coating are tailored by tuning the values of x, y, z, a and b.
    Type: Application
    Filed: September 15, 2016
    Publication date: March 30, 2017
    Inventors: Gianfranco Aresta, Gareth Hennighan, Andrew Simon Hall Brooks, Shailendra Vikram Singh
  • OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20170066753
    Abstract: The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.
    Type: Application
    Filed: June 10, 2016
    Publication date: March 9, 2017
    Inventors: Raksha Acharya, Duane A. Burnett, Matthew Gregory Bursavich, Andrew Simon Cook, Bryce Alden Harrison, Andrew J. McRiner
  • Geminal Substituted Aminobenzisoxazole Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors
    Publication number: 20170044155
    Abstract: The present invention relates to novel geminal substituted aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ?7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
    Type: Application
    Filed: August 10, 2016
    Publication date: February 16, 2017
    Inventors: Raksha Acharya, Duane A. Burnett, Matthew Gregory Bursavich, Andrew Simon Cook, Bryce Alden Harrison, Andrew J. McRiner
  • INHIBITORS OF HIV REPLICATION
    Publication number: 20160355528
    Abstract: The present invention relates to novel 2,3,4-substituted 5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridine compounds and pharmaceutically acceptable salts thereof, to compositions containing such compounds and to the use of such compounds as inhibitors of HIV replication.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Applicant: VIIV HEALTHCARE UK LIMITED
    Inventors: Andrew Simon BELL, Iain Brian GARDNER, Karl Richard GIBSON, David Cameron PRYDE, Florian Michel WAKENHUT
  • Inhibitors of HIV replication
    Patent number: 9447116
    Abstract: The present invention relates to novel 2,3,4-substituted 5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridine compounds and pharmaceutically acceptable salts thereof, to compositions containing such compounds and to the use of such compounds as inhibitors of HIV replication.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: September 20, 2016
    Assignee: ViiV Healthcare UK Limited
    Inventors: Andrew Simon Bell, Iain Brian Gardner, Karl Richard Gibson, David Cameron Pryde, Florian Michel Wakenhut
  • Light source
    Patent number: 9396924
    Abstract: An electrodeless, microwave lamp has a magnetron as a microwave source and an excitable material lucent crucible in whose excitable material a plasma is established. For coupling microwaves from the magnetron into the crucible, an air wave guide coupling circuit is provided, with an output of the magnetron as an input at one quarter lambda from one end and an output at one quarter from the other end as an input to a connection to the crucible.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: July 19, 2016
    Assignee: Ceravision Limited
    Inventor: Andrew Simon Neate