Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Described are robotic signs comprising: a sign post; an arm movably attached to the sign post, the arm having a positioning apparatus configured to allow the arm to rotate independently and contiguously around the sign post, the arm having at least one face comprising an electronic display configured to present display items; and a communication element configured to receive display item information from a remote administration application, the display item information comprising a direction and a description; wherein upon presenting a display item, an arm rotates to indicate the direction and displays the description. Also described are software applications for configuring the robotic signs, networks of the robotic signs, and advertising systems utilizing the robotic signs.

Abstract: The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the human corticotropin-releasing factor receptor-1 (CRF1R) structure listed in Table A, Table B or Table C, optionally varied by a root mean square deviation of residue backbone atoms of not more than 4.383 ?, or selected coordinates thereof; and predicting the three-dimensional structural representation of the target protein, or part thereof, by modelling the structural representation on all or the selected coordinates of the CRF1R structure. The invention also provides the use of the CRF1R coordinates to select or design one or more binding partners of CRF1R.

Abstract: An energy management system and method connecting a load to multiple energy sources. The system includes a load connection, source connections for each energy source, a control unit and at least one energy management module having an inductor and four switches. The first source is in parallel with the load. The first switch couples the first source positive terminal to the first inductor end, second switch couples the first source negative terminal to the first inductor end, third switch couples the second source positive terminal to the second inductor end, and fourth switch couples the second source negative terminal to the second inductor end. The control unit controls the four switches of each module to transfer energy between the energy sources through the module inductor. The system can have more than two sources. Modes including one or two switch, synchronous or asynchronous, and buck or boost can be used.

Abstract: Incentive rewards awarded to a recipient have a code unique to each reward. Receipt of a reward may be reported by the Internet or the intranet. Plural rewards can be connected together to form a trophy. The incentive rewards can be connected to one another by the use of magnets on the rewards.

Abstract: A system, method, and computer program product are provided for implementing a pinlight see-through near-eye display. Light cones configured to substantially fill a field-of-view corresponding to a pupil are generated by an array of pinlights positioned between a near focus plane and the pupil. Overlap regions where two of more light cones intersect at a display layer positioned between the array of pinlights and the pupil are determined. The two or more light cones are modulated based on the overlap regions to produce a target image at or beyond the near focus plane.

Abstract: According to a method herein, a number of pixels marked and times of printing are automatically determined for a plurality of images. A time-based moving window of pixel counts for a subset of the plurality of images being contiguously processed in a current time window is automatically calculated, based on the number of pixels marked and the times of printing of the subset of the plurality of images processed in the current time window. Marking material usage to print the plurality of images for the current time window is automatically determined, based on the time-based moving window of pixel counts of the current time window. The method automatically determines if the marking material usage for the current time window exceeds a threshold. A notification is automatically output if the marking material usage for the current time window exceeds the threshold.

Abstract: Devices and methods to determine media size in a printing device. Media being added to a media sheet tray of a printing device is detected. A size of the media in the tray is estimated based only on at least one of: a size of the media in the tray prior to the media being added, a size of the media recently used prior to the media being added, and a size of the media most frequently used. A selection of previously used sizes of media is displayed on a user interface. The selection comprises: the size of the media in the tray prior to the media being added, the size of the media recently used prior to the media being added, and the size of the media most frequently used. Confirmation of the size of the media added to the tray is received, on the user interface.

Abstract: A user-friendly crane mat carrier is provided for conveniently transporting, storing and supporting crane mats, pads and other items. The economical light weight crane mat assembly can comprise a frame assembly with a main load-supporting bar, crossbars and perimeter bars. The special crane mat carrier can be easily connected to a crane, such as with a drawbar fixture, securing plate and locking plate. A hanger assembly with a suspension bar can be provided to hang the crane mat carrier. A latch mechanism can also be provided to securely lock the crane mat carrier.

Abstract: A method is provided for storing energy including the steps of: during a time period when electrical energy is available at low prices, pumping water from a lower reservoir to a reservoir at a higher elevation wherein the difference between the elevation of the higher reservoir and the lower reservoir is at least 100 meters; during a time period when electrical energy is available at a higher price, utilizing a Pelton turbine to generate mechanical energy using the difference between the potential energy of the water at the higher reservoir and the lower reservoir and thereby transferring water from the higher reservoir to the lower reservoir; converting the mechanical energy to electrical energy; and when the mechanical power is not being generated, maintaining the Pelton turbine in a spinning stand-by mode.

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: A converter system and inverter system are disclosed with individual real and reactive power control for each phase of a poly-phase system. The converter system includes a controller, bidirectional single-phase inverters with AC sides coupled to an AC line filter and DC sides connected in parallel to a link capacitor coupled to DC/DC converters. Each inverter handles a separate AC phase. The controller controls the inverters and DC/DC converters so the current amplitude of each AC phase is independent, and the phase difference of each AC phase is independent. The inverters can be galvanically isolated between the DC and AC sides. The inverters can be non-isolated inverters having line and neutral connectors coupled to an isolated transformer winding, and the output windings of the transformer can be wired in a Wye configuration. The inverters can have local controllers.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: An energy management system and method connecting a load to multiple energy sources. The system includes a load connection, source connections for each energy source, a control unit and at least one energy management module having an inductor and four switches. The first source is in parallel with the load. The first switch couples the first source positive terminal to the first inductor end, second switch couples the first source negative terminal to the first inductor end, third switch couples the second source positive terminal to the second inductor end, and fourth switch couples the second source negative terminal to the second inductor end. The control unit controls the four switches of each module to transfer energy between the energy sources through the module inductor. The system can have more than two sources. Modes including one or two switch, synchronous or asynchronous, and buck or boost can be used.

Abstract: The invention relates to a method for detecting the presence or absence of a bacterial pathogen in a biological sample obtained from a human or animal subject, using an internal control. In particular, the invention relates to a method for detecting the presence or absence of Streptococcus equi in an equine sample using a control bacterial strain as internal control for DNA extraction and PCR. The invention also relates to host cells (such as bacterial cells) and nucleic acids for use as internal standard in said method in addition to diagnostic kits comprising said host cells and nucleic acids.

Abstract: A separator module for a stormwater gully chamber is disclosed, the separator module comprising: a partition arrangement which, in use, divides the chamber into an upper region and a lower region, the partition arrangement comprising: an inlet chute having an opening which, in use, provides an inlet to the lower region from the upper region; an outlet chute having an opening which, in use, provides an outlet from the lower region to the upper region; and a weir separating the outlet chute from the inlet chute; wherein at least a portion of the partition arrangement is flexible so as to allow an external diameter of the partition arrangement to be adjusted to fit different sized chambers.

Abstract: Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: An apparatus, system, and method provide electrostatic discharge (ESD) protection in electronic devices. The ESD channels are positioned within the electrical insulation sheet to provide electrical paths to ground having a lower impedance than electrical paths to protected areas covered by the electrical insulation sheet. An ESD follows the path of least resistance safely to ground rather than to a critical component within the electronic device. The ESD channels are openings in a dome contact layer of a keypad where the openings are positioned over one or more ground areas of a printed circuit board (PCB) and the insulating material of the dome contact layer covers areas of the PCB that are protected from ESD. By implementing dedicated GPIO lines, grounded metal domes cover the signal pads in the target discharge area to protected the GPIO lines from ESD. Device components are protected from ESD without additional ports or insulation.

Abstract: Described are robotic signs comprising: a sign post; an arm movably attached to the sign post, the arm having a positioning apparatus configured to allow the arm to rotate independently and contiguously around the sign post, the arm having at least one face comprising an electronic display configured to present display items; and a communication element configured to receive display item information from a remote administration application, the display item information comprising a direction and a description; wherein upon presenting a display item, an arm rotates to indicate the direction and displays the description. Also described are software applications for configuring the robotic signs, networks of the robotic signs, and advertising systems utilizing the robotic signs.