Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Human somatic cells obtained from individuals with a genetic heart condition are reprogrammed to become induced pluripotent stem cells (iPS cells), and differentiated into cardiomyocytes for use in analysis, screening programs, and the like.

Abstract: There is provided an air spring for supporting a load, the air spring comprises a chamber for holding a pressurised gas in use, a load-bearing surface arranged to transmit a force from a load in use to the pressurised gas held in the chamber. Importantly, in order to lower the spring rate, the chamber contains a mass of adsorptive material. There is also provided a use of an adsorptive material for the purpose of lowering the spring rate of an air spring, including a gas strut and a pneumatic wheel. There is also provided a method of designing an air spring using an adsorptive material to lower the spring rate.

Abstract: A current measurement circuit includes first and second input nodes which receive the respective voltages at either side of a resistive element through which electrical current can flow, a differential amplifier means which produces an output signal indicative of the difference in voltage between its input terminals, electrical path forming means providing a connection between each of the input nodes and a respective input terminal of the differential amplifiers, a controllable voltage source for selectively applying an offset voltage to at least one input of the differential amplifier in response to a control signal, a control signal generator which generates the control signal applied to the voltage source such that at a first instance an offset voltage is applied which is greater than that applied at a second instance, and a diagnostic means which is adapted to identify faults present in the electrical path between the first input node and the respective input to the amplifier by comparing the output from

Abstract: This invention relates to compounds selected in the group consisting of compounds of formula (Ia) to (Id) and compositions, that are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: A mobile surface cleaning robot including a robot body having a forward drive direction, a drive system supporting the robot body above a floor surface for maneuvering the robot across the floor surface, and a robot controller in communication with the drive system. The robot also includes a collection volume supported by the robot body and a cleaning module releasably supported by the robot body and arranged to clean the floor surface. The cleaning module includes a first vacuum squeegee having a first duct, a driven roller brush rotatably supported rearward of the first vacuum squeegee, a second vacuum squeegee disposed rearward of the roller brush and having a second duct, and a third duct in fluid communication with the first and second ducts. The third duct is connectable to the collection volume at a fluid-tight interface formed by selectively engaging the cartridge with the robot body.

Abstract: Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract

Abstract: A vehicle 1 towing a trailer 4 is fitted with three video cameras 5, 6, 7 fitted to the rear of the vehicle and on each door mirror. A view from any camera can be presented to the driver on a display 11. A predicted trailer path, calculated in a computing unit 10, is also presented to the driver on the display 11 as guide lines overlaid on the camera view. The computing unit 10 is also configured to calculate a hitch angle by tracking the position of a trailer-mounted marker in the camera view.

Abstract: An energy management system and method connecting a load to multiple energy sources. The system includes a load connection, source connections for each energy source, a control unit and at least one energy management module having an inductor and four switches. The first source is in parallel with the load. The first switch couples the first source positive terminal to the first inductor end, second switch couples the first source negative terminal to the first inductor end, third switch couples the second source positive terminal to the second inductor end, and fourth switch couples the second source negative terminal to the second inductor end. The control unit controls the four switches of each module to transfer energy between the energy sources through the module inductor. The system can have more than two sources. Modes including one or two switch, synchronous or asynchronous, and buck or boost can be used.

Abstract: According to a method herein, a number of pixels marked and times of printing are automatically determined for a plurality of images. A time-based moving window of pixel counts for a subset of the plurality of images being contiguously processed in a current time window is automatically calculated, based on the number of pixels marked and the times of printing of the subset of the plurality of images processed in the current time window. Marking material usage to print the plurality of images for the current time window is automatically determined, based on the time-based moving window of pixel counts of the current time window. The method automatically determines if the marking material usage for the current time window exceeds a threshold. A notification is automatically output if the marking material usage for the current time window exceeds the threshold.

Abstract: Described are robotic signs comprising: a sign post; an arm movably attached to the sign post, the arm having a positioning apparatus configured to allow the arm to rotate independently and contiguously around the sign post, the arm having at least one face comprising an electronic display configured to present display items; and a communication element configured to receive display item information from a remote administration application, the display item information comprising a direction and a description; wherein upon presenting a display item, an arm rotates to indicate the direction and displays the description. Also described are software applications for configuring the robotic signs, networks of the robotic signs, and advertising systems utilizing the robotic signs.

Abstract: An engine component with particulate mitigation features is provided. The engine component comprises an internal engine component surface having a cooling flow path on one side thereof and a second component adjacent to the first component. The second component, for example an insert, may have a plurality of openings forming an array wherein the openings extend through the second component at a non-orthogonal angle to the surface of the second component.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: This invention relates to compounds and compositions that are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Devices and methods to determine media size in a printing device. Media being added to a media sheet tray of a printing device is detected. A size of the media in the tray is estimated based only on at least one of: a size of the media in the tray prior to the media being added, a size of the media recently used prior to the media being added, and a size of the media most frequently used. A selection of previously used sizes of media is displayed on a user interface. The selection comprises: the size of the media in the tray prior to the media being added, the size of the media recently used prior to the media being added, and the size of the media most frequently used. Confirmation of the size of the media added to the tray is received, on the user interface.

Abstract: A vehicle 1 towing a trailer 4 is fitted with three video cameras 5, 6, 7 fitted to the rear of the vehicle and on each door mirror. A view from any camera can be presented to the driver on a display 11. A predicted trailer path, calculated in a computing unit 10, is also presented to the driver on the display 11 as guide lines overlaid on the camera view. The computing unit 10 is also configured to calculate a hitch angle by tracking the position of a trailer-mounted marker in the camera view.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Described are robotic signs comprising: a sign post; an arm movably attached to the sign post, the arm having a positioning apparatus configured to allow the arm to rotate independently and contiguously around the sign post, the arm having at least one face comprising an electronic display configured to present display items; and a communication element configured to receive display item information from a remote administration application, the display item information comprising a direction and a description; wherein upon presenting a display item, an arm rotates to indicate the direction and displays the description. Also described are software applications for configuring the robotic signs, networks of the robotic signs, and advertising systems utilizing the robotic signs.