Abstract: A method for forming a fiber-reinforced thermoplastic control surface includes forming first and second skins from a fiber-reinforced thermoplastic resin. The method further includes overmolding fiber-reinforced thermoplastic features onto the first skin and/or second skin, including stiffener structures, sidewalls, and/or hinges. The method further comprises welding or consolidating the first and second skins together, along with the associated internal features overmolded thereon to form a single-piece, stiffened, fiber-reinforced thermoplastic control surface.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy.

Abstract: Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Abstract: The present invention relates to a confectionery composition that has the necessary stability and texture to be used as filling in foodstuffs, preferably chocolate confectionery products.

Abstract: Disclosed herein is a system and a method of providing access to at least one password protected device (D1-D5) via a password management system (100). The password management system (100) comprises first and second password management servers (200), each comprising a memory for storing an active password and a reserve password. The first and second password management servers (200) communicate the active and reserve passwords via a communication link (220). Either one of the first and second password management servers (200) requests access to the password protected device using the active password stored in the memory, and if the active password does not provide access, requests access using the reserve password.

Abstract: Provided herein are methods of treating or preventing a fungal colonisation or infection in a subject. The method includes administering a therapeutically effective amount of a compound, or a therapeutically acceptable salt thereof, to the subject, wherein the fungal colonisation or infection is caused by a fungal agent.

Abstract: Quantum processing devices and methods for shuttling qubits between a pair of processing elements are disclosed. In particular, a disclosed method for shuttling a qubit from a first processing element to a second processing element in a quantum processing device comprising a plurality of processing elements, includes: applying an optimal bias configuration between the first processing element and the second processing element to shuttle the qubit from the first processing element to the second processing element in a manner that minimizes the time spent by the qubit in one or more state transition points between the first processing element and the second processing element.

Abstract: The present invention relates to amorphous porous particles comprising sugar, a bulking agent and surfactant, having a closed porosity of between 20 to 60% a sphericity of at least between 0.8 and 1. In a further aspect the present invention relates to a process of making said amorphous porous particles and their use as bulk sugar replacers in food products such as fat based confectionery products for example, chocolate.

Abstract: A method and a system are for sparse sampling utilizing a programmatically randomized signal for modulating a carrier signal. The system includes a compound sparse sampling pattern generator that generates at least one primary carrier signal, and at least one secondary signal. The at least one secondary signal modulates the at least one primary signal in a randomized fashion.

Abstract: The present invention relates to plumbing fixtures, and more particularly to drain stopper assemblies used to control the flow of fluid through a drain opening of a sink or bathtub. More specifically, the present invention is a novel drain stopper device that can be attached or removed from a drain without the use of tools and without requiring a user to access the space underneath the drain. The device is preferably comprised of a drain stopper head portion having a repositionable push button in mechanical communication with a spring, a shaft and a pair of repositionable jaws such that the pair of jaws are repositioned to grip or release a pivot rod when the push button is repositioned between a first and a second position.

Abstract: This invention is a tubular shaped flying toy comprised of a polypropylene (foam) main cylindrical body with a heavy plastic ring supported front end. The main foam body is held in place to the plastic ring support with the help of rubber bracelet bands that stretch around the outside of the front end of the toy where the foam body stretches onto the hard plastic ring. The toy is thrown with a baseball type throwing motion, and provides a graceful, smooth flight.

Abstract: In some implementations, a device may store a set of data in a first database associated with a fixed storage duration and a storage parameter that restricts access associated with adding or modifying information stored in the first database. The device may process a subset of data from the set of data, wherein processing the subset of data includes performing one or more data processing operations performed via data processing operation documentation that defines the one or more data processing operations. The device may store the data processing operation documentation in a second database associated with a variable storage duration for data stored in the second database. The device may provide the first database and the second database as data sources for a data searching application to enable the first database and the second database to be searchable via a dashboard associated with the data searching application.

Abstract: A portable hydration device for use with a portable hydration system is described. The portable hydration device comprises a housing having an inlet, configured to be in fluid communication with a reservoir of water, and an outlet configured to be in fluid communication with a mouthpiece; the housing defining a throughbore connecting the inlet and the outlet. The device also includes a receptacle configured to contain an additive and a selector. The selector is movable between an engaged position in which the selector is engaged with the receptacle and a disengaged position in which the selector is disengaged from the receptacle. In the engaged position the selector permits fluid communication between the receptacle and the throughbore and in the disengaged position the selector prevents fluid communication between the receptacle and the throughbore. The selector defines a throughbore, the selector throughbore being aligned with the housing throughbore in the engaged and the disengaged positions.

Abstract: This invention is a tubular shaped flying toy comprised of a polypropylene (foam) main cylindrical body with a heavy plastic ring supported front end. The main foam body is held in place to the plastic ring support with the help of rubber bracelet bands that stretch around the outside of the front end of the toy where the foam body stretches onto the hard plastic ring. The toy is thrown with a baseball type throwing motion, and provides a graceful, smooth flight.