Abstract: Described herein are compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof. Also disclosed are compositions containing the compounds, methods of inhibiting activity of DYRK1A in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: The invention provides a molecular classifier and a targeted sequencing assay for use in characterization and treatment of diffuse large B-cell lymphoma.

Abstract: Textile compositions comprising at least one filamentous fungus are disclosed, as are methods for making and using such textile compositions. Embodiments of the textile compositions generally include at least one of a plasticizer, a polymer, and a crosslinker, in addition to the filamentous fungus. The disclosed textile compositions are particularly useful as analogs or substitutes for conventional textile compositions, including but not limited to leather.

Abstract: A patient interface system for delivery of respiratory therapy to a patient comprises: a nasal portion including a nasal chamber and a nasal sealing portion adapted to form a seal with the patients including an opening; an inlet conduit connected to the nasal portion to deliver the pressurized, breathable gas to the nasal chamber; and a nasal chamber coupling component adapted to form part of a releasable fluid coupling to enable the nasal portion to be fluidly coupled to a mouth portion to communicate a portion of the pressurized, breathable gas through the nasal chamber opening to the mouth portion.

Abstract: In accordance with a designation of a private alias endpoint as a routing target for traffic directed to a service from within an isolated virtual network of a provider network, a tunneling intermediary receives a baseline packet generated at a compute instance. The baseline packet indicates a public IP (Internet Protocol) address of the service as the destination, and a private IP address of the compute instance as the source. In accordance with a tunneling protocol, the tunneling intermediary generates an encapsulation packet comprising at least a portion of the baseline packet and a header indicating the isolated virtual network. The encapsulation packet is transmitted to a node of the service.

Abstract: A pressure switch is provided and includes an elastic membrane disposed such that pressure from fluid within a fluid path deforms the elastic membrane toward a plunger, thereby moving the plunger. The plunger is disposed between the membrane and an upper plate and is moveable along an axis extending between the membrane and the upper plate. A threshold pressure on the membrane from the fluid within the fluid path deforms the membrane, thereby moving the plunger toward the upper plate.

Abstract: Textile compositions comprising at least one filamentous fungus are disclosed, as are methods for making and using such textile compositions. Embodiments of the textile compositions generally include at least one of a plasticizer, a polymer, and a crosslinker, in addition to the filamentous fungus. The disclosed textile compositions are particularly useful as analogs or substitutes for conventional textile compositions, including but not limited to leather.

Abstract: Provided are compounds of Formula (I?) or (I) below, or pharmaceutically acceptable salts thereof, and methods for their use and production.

Abstract: Methods, systems, and computer program products are provided for conducting real-time auction events based on a countdown timer. The method includes receiving product data associated with a product including a price of the product, generating a live auction event associated with the product, incrementally decreasing the price of the product based on a countdown timer, receiving a bid order request including bid data associated with a bid order for the product, the bid data including a bid price, a bid quantity, and a bid identifier, the bid identifier corresponding to a user account of a user, and fulfilling the bid order request based on the bid price of the bid order request.

Abstract: Techniques for using a network to decompose an HRTF data set to generate approximation data and to render an audio signal using the approximation data are disclosed herein. An input HRTF data set is fed into the network, which then generates approximation data that includes mixing channel gains, FIR filter coefficients, and basis filter shapes. This approximation data controls various components in the network. When the input HRTF data set is fed as input into the network, then the output of the network is an output approximated HRTF data set. The network iteratively fine tunes the approximation data until the output approximated HRTF data set sufficiently matches the input HRTF data set. After the approximation data is sufficiently tuned, the approximation data is later used by the network to render an audio signal.

Abstract: Redox active S-linked polymers, sulfurized matrices, and related composites, compositions electrode material, electrodes, as well as related electrode chemical cell battery, methods and systems are described. In particular, S-linked polymers and related compositions, composites, electrode material and electrodes having a redox potential of up to 3.5 V with reference to Li/Li+ electrode potential under standard conditions and a capacity up to 800 mAh/g or higher are described. More particularly, redox active S-linked polymers, sulfurized matrices, and related composites, and compositions are provided as electrode material of a cathode for an electrochemical cell further containing a Li anode and a non-aqueous electrolyte.

Abstract: This invention related to a coupler for securing an attachment to an earth working machine. The coupler comprises a coupler body that presents a receptacle having a capture region. A pin of an attachment can move into and out of the capture region. A retainer can capture the pin in the capture region but the retainer can be moved by a hydraulically driven driver to a position to allow release the pin from the capture region. A trigger that the pin will strike when the pin moves into or out of the capture region, decouples the driver from the retainer and the retainer is then allowed to be biased back to its retaining position by a spring.

Abstract: The description relates to representing acoustic characteristics of real or virtual scenes. One method includes generating directional impulse responses for a scene. The directional impulse responses can correspond to sound departing from multiple sound source locations and arriving at multiple listener locations in the scene. The method can include processing the directional impulse responses to obtain coherent sound signals and incoherent sound signals. The method can also include encoding first perceptual acoustic parameters from the coherent sound signals and second perceptual acoustic parameters from the incoherent sound signals, and outputting the encoded first perceptual acoustic parameters and the encoded second perceptual acoustic parameters.

Abstract: Redox active polycyclic compounds and related electrode material, electrode chemical cell battery, methods and systems are described. In particular, tricyclic compounds having a redox potential of 0.20 V to 2.0 V with reference to Zn/Zn2+ electrode potential under standard conditions are described. More particularly, redox active monomers, dimers, and polymers in which each monomeric unit contains a tricyclic heterocyclic structure are provided as electrode material of a cathode for an electrochemical cell further containing a zinc anode and an aqueous electrolyte.

Abstract: Described herein are compounds having the following structure: formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof. Also disclosed are compositions containing the compounds, methods of inhibiting activity of DYRK1 A in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: Systems and methods are disclosed for automatically determining property value, the systems and methods perform operations comprising: receiving, by a server, subject real-estate property listing information associated with a subject real-estate property; identifying a plurality of comparable real-estate property listings based on attributes of the subject real-estate property listing information; processing the subject real-estate property listing information together with the plurality of comparable real-estate property listings using a trained machine learning technique to predict a value for the subject real-estate property, the trained machine learning technique being trained to jointly establish a relationship between weights assigned to a set of training comparable real-estate property listings and value adjustments of the set of training comparable real-estate property listings and a value of a real-estate property of interest; and performing an action with respect to the subject real-estate property

Abstract: Systems and methods for the external aiding of inertial navigation systems are described herein. In certain embodiments, a device includes an inertial navigation system. In some embodiments, the inertial navigation system includes one or more inertial sensors and an input interface for receiving measurements. In further embodiments, the measurements include at least one of delta attitude and/or delta position measurements from an external system, and position and attitude information in an arbitrary map frame. In certain embodiments, the inertial navigation system includes a computation device that is configured to calibrate the errors from the one or more inertial sensors using the received measurements.

Abstract: A fan assembly includes a fan body, a motor-driven impeller contained within the fan body and arranged to generate an air flow, a nozzle including a nozzle body having an air inlet arranged to receive the air flow from the fan body, and one or more air outlets arranged to emit the airflow from the fan assembly. The fan assembly further includes a nozzle retaining mechanism for releasably retaining the nozzle on the fan body, and a rotation mechanism for rotating the nozzle body relative to the fan body. The nozzle rotation mechanism includes a rotation motor arranged to drive a drive member and a driven member that is arranged to be driven by the drive member to rotate around a rotation axis.

Abstract: Techniques for using a network to decompose an HRTF data set to generate approximation data and to render an audio signal using the approximation data are disclosed herein. An input HRTF data set is fed into the network, which then generates approximation data that includes mixing channel gains, FIR filter coefficients, and basis filter shapes. This approximation data controls various components in the network. When the input HRTF data set is fed as input into the network, then the output of the network is an output approximated HRTF data set. The network iteratively fine tunes the approximation data until the output approximated HRTF data set sufficiently matches the input HRTF data set. After the approximation data is sufficiently tuned, the approximation data is later used by the network to render an audio signal.