Abstract: A suture passer includes a shaft having an axis, a first jaw mounted to the shaft in alignment with the axis, the first jaw being configured to releasably support a length of suture thereon; a second jaw movably mounted to the shaft, and a needle movably mounted to the shaft, the needle having a hook and being configured to reciprocate in alignment with the axis so that the hook can selectively pass by the second jaw and engage suture releasably supported on the first jaw, wherein the first jaw comprises a spring for selectively binding the suture to the first jaw, and further wherein the spring comprises a recess for receiving the suture therein.

Abstract: A fan assembly includes a fan body, a motor-driven impeller contained within the fan body and arranged to generate an air flow, a nozzle including a nozzle body having an air inlet arranged to receive the air flow from the fan body, and one or more air outlets arranged to emit the airflow from the fan assembly. The fan assembly further includes a nozzle retaining mechanism for releasably retaining the nozzle on the fan body, and a rotation mechanism for rotating the nozzle body relative to the fan body. The nozzle rotation mechanism includes a rotation motor arranged to drive a drive member and a driven member that is arranged to be driven by the drive member to rotate around a rotation axis.

Abstract: Some implementations are directed to a wireless receiver. In some implementations, the wireless receiver may include a receiver body encompassing one or more antenna elements, a cover removably coupled to the receiver body, and a mounting bracket removably coupled to the receiver body. In some implementations, at least one of the one or more antenna elements, the cover, or the mounting bracket is movable with respect to the receiver body in order to align the wireless receiver with a signal path.

Abstract: Contents of client-initiated handshake messages of a security protocol are obtained at a handshake processing offloader configured for an application. The offloader uses a first security artifact (which is inaccessible from a front-end request processor of the application) and the contents of the handshake messages to generate a second security artifact. The second security artifact is transmitted to the front-end request processor, which uses it to perform cryptographic operations for client-server interactions of the application.

Abstract: Systems and methods for a tightly coupled end-to-end multi-sensor fusion with integrated compensation are described herein. For example, a system includes an inertial measurement unit that produces inertial measurements. Additionally, the system includes additional sensors that produce additional measurements. Further, the system includes one or more memory units. Moreover, the system includes one or more processors configured to receive the inertial measurements and the additional measurements. Additionally, the one or more processors are configured to compensate the inertial measurements with a compensation model stored on the one or more memory units. Also, the one or more processors are configured to fuse the inertial measurements with the additional measurements using a differential filter that applies filter coefficients stored on the one or more memory units.

Abstract: Techniques for using a network to decompose an HRTF data set to generate approximation data and to render an audio signal using the approximation data are disclosed herein. An input HRTF data set is fed into the network, which then generates approximation data that includes mixing channel gains, FIR filter coefficients, and basis filter shapes. This approximation data controls various components in the network. When the input HRTF data set is fed as input into the network, then the output of the network is an output approximated HRTF data set. The network iteratively fine tunes the approximation data until the output approximated HRTF data set sufficiently matches the input HRTF data set. After the approximation data is sufficiently tuned, the approximation data is later used by the network to render an audio signal.

Abstract: Systems and methods for multiple inertial measurement unit sensor fusion using machine learning are provided herein. In certain embodiments, a system includes inertial sensors that produce inertial measurements, a memory unit that stores a fusion model produced by at least one machine learning algorithm, and a processor that receives inertial measurements, where the processor applies the fusion model to the inertial measurements. The fusion model directs the processor to extract features from the inertial measurements, and to select inertial measurements based on a sensor in the plurality of inertial sensors that produced the inertial measurements. Also, the fusion model directs the processor to apply weights to the selected inertial measurements based on the extracted features, to apply compensation coefficients to the selected inertial measurements, and to fuse the selected inertial measurements into an inertial navigation solution.

Abstract: Provided are compounds of the Formula (IIB): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.

Abstract: A coupler for securing an attachment to an earth working machine. The coupler Includes a coupler body that presents a receptacle having a capture region. A pin of an attachment can move into and out of the capture region. A retainer can capture the pin in the capture region but the retainer can be moved by a hydraulically driven driver to a position to allow release of the pin from the capture region. A trigger that the pin will strike when the pin moves into or out of the capture region, decouples the driver from the retainer and the retainer is then allowed to be biased back to its retaining position by a spring.

Abstract: Provided here are cells engineered for therapeutic purposes to express multiple proteins, including an anti-BCMA (B cell maturation antigen), anti-CD3 bispecific antibody. Also provided are new anti-BCMA, anti-CD3 bispecific antibodies with associated sequences. Further disclosed is a mesenchymal stem cell (MSC) comprising an exogenous mRNA encoding an anti-BCMA and anti-CD3 antibody, and an exogenous mRNA encoding a single-chain interleukin-12 (IL-12) fusion protein.

Abstract: This disclosure is drawn to pyridine derivatives, compositions thereof, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders.

Abstract: Provided are compounds of the Formula (IVB): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

Abstract: Provided herein are biosynthetic methods for producing lactones, such as macrocyclic lactones, from fatty acids. The lactones produced using and/or during the biosynthetic methods are also provided.

Abstract: Provided are compounds of the Formula (IIB): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.

Abstract: Techniques for generating a simulated reverberation sound signal are disclosed. This simulated reverberation sound signal operates as a reverberation effect for a sound associated with a source. The simulated reverberation sound signal is generated using a truncated sound signal that (i) repeats in a decaying manner over time, (ii) has a perceivable arrival direction that approximates where the sound originated, and (iii) has a given shape on a sound sphere.

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

Abstract: A traffic manager module of a cyber threat defense platform that can differentiate between data flows to a client device. A registration module can register a connection between devices within a client network to transmit a series of data packets. A classifier module can execute a comparison of features of the connection to a set of interest criteria to determine an interest level for the cyber threat defense platform in the connection. The classifier module can apply an interest classifier describing the interest level to the connection based on the comparison. A deep packet inspection engine can examine the data packets of the connection for cyber threats if the interest classifier indicates interest. A diverter can shunt the data packets of the connection away from the deep packet inspection engine if the interest classifier indicates no interest.

Abstract: A computer-implemented method can include: visually presenting visual stimuli to participants in multiple runs, wherein the visual stimuli include pairs of images, each pair including a reference product image and a competitor product image; performing multiple scans on the participants during passive viewing of the visual presenting, the scans including functional magnetic resonance imaging (fMRI); and determining a similarity index based on results of the scans, the similarity index indicating a level a perceived similarity between the reference product image and the competitor product image.