Abstract: This invention related to a coupler for securing an attachment to an earth working machine. The coupler comprises a coupler body that presents a receptacle having a capture region. A pin of an attachment can move into and out of the capture region. A retainer can capture the pin in the capture region but the retainer can be moved by a hydraulically driven driver to a position to allow release the pin from the capture region. A trigger that the pin will strike when the pin moves into or out of the capture region, decouples the driver from the retainer and the retainer is then allowed to be biased back to its retaining position by a spring.

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

Abstract: A charging structure for a vaporizer. The charging structure includes a housing, a first electrical contact coupled to and extending outward from a first end of the housing, a spacer coupled to the first electrical contact, and a second electrical contact coupled to and extending outward from the spacer. The first electrical contact includes an exposed outer surface that extends in a continuous loop. The second electrical contact includes an exposed side surface that extends in a continuous loop and an end surface coupled to the side surface. Both the side surface and the end surface are electrically conductive. A vaporizer including the charging structure.

Abstract: A charging structure for a vaporizer. The charging structure includes a housing, a first electrical contact coupled to and extending outward from a first end of the housing, a spacer coupled to the first electrical contact, and a second electrical contact coupled to and extending outward from the spacer. The first electrical contact includes an exposed outer surface that extends in a continuous loop. The second electrical contact includes an exposed side surface that extends in a continuous loop and an end surface coupled to the side surface. Both the side surface and the end surface are electrically conductive. A vaporizer including the charging structure.

Abstract: A charging structure for a vaporizer. The charging structure includes a housing, a first electrical contact coupled to and extending outward from a first end of the housing, a spacer coupled to the first electrical contact, and a second electrical contact coupled to and extending outward from the spacer. The first electrical contact includes an exposed outer surface that extends in a continuous loop. The second electrical contact includes an exposed side surface that extends in a continuous loop and an end surface coupled to the side surface. Both the side surface and the end surface are electrically conductive. A vaporizer including the charging structure.

Abstract: Described herein are compounds having the following structure: formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof. Also disclosed are compositions containing the compounds, methods of inhibiting activity of DYRK1 A in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

Abstract: Devices and methods are provided for out-of-home transmissions for digital video recorders. The device may receive, at a first port of the device, a first packet from a second device using a peer-to-peer (P2P) connection between the device and a second device, first packet including a first session identifier associated with a first socket based on the first port and a second port of the second device. The device may receive a second packet from the second device using the P2P connection, the second packet including a second session identifier. The device may determine a second socket based on the second session identifier, the second socket based on the first port and a third port of the second device. The device may send a third packet using the second socket, the third packet including the second session identifier.

Abstract: An Inertial Measurement Unit (IMU), method, and navigation system are disclosed. For example, the method includes receiving a plurality of sensor values from an IMU, loading the plurality of sensor values and a plurality of true sensor values into a deep learning algorithm, and training the deep learning algorithm to enhance the accuracy of the plurality of sensor values utilizing the plurality of true sensor values.

Abstract: The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R5, R6, and = are as defined herein. The present invention also relates to compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Abstract: Provided herein are chimeric antigen receptors (CARs), such as those specific for BCMA, that have improved properties, including increased CAR T cell binding to BCMA and improved CAR T cell killing of BCMA-expressing cancer cells. Use of the CARs in immune cells (e.g., T cells), compositions (e.g., CARs and nucleic acid constructs encoding the same), and methods are also contemplated.

Abstract: A dispenser with a housing, a plunger, and an activation mechanism coupled to the plunger. The housing defines a reservoir configured to retain a liquid and a dispensing orifice in fluid communication with the reservoir. The plunger is configured to move through the reservoir toward the dispensing orifice to dispense the liquid through the dispensing orifice. The activation mechanism is configured to be moved by a user, and movement of the activation mechanism in a first direction causes the plunger to move toward the dispensing orifice. At least one of the activation mechanism and the housing is configured to provide feedback to a user when the activation mechanism moves a predetermined distance in the first direction. A method of using the dispenser.

Abstract: The present invention is directed to a vape device configured to determine the dose of a payload delivered to a user during each of a plurality of user inhalations. In a first embodiment, the vape device tracks the energy used to vaporize a portion of the payload during user inhalation to determine the dose. In a second embodiment, the vape device measures the temperature at multiple locations within the air flow chamber during user inhalation to determine the dose. In a third embodiment, the vape device measures the intensity of light that is transmitted through the vaporized payload, reflected off the vaporized payload, or transmitted through a light transmitting medium positioned within the vaporized payload, during user inhalation to determine the dose.