Abstract: Treatment of patients with the 2S,4R ketoconazole enantiomer or its pharmaceutically acceptable salts, and solvates is useful for reducing systemic inflammation and cholesterol levels and improving glycemic control.

Abstract: The subject matter of the present disclosure generally relates to objective lens changers for optical instruments. In one embodiment, an objective lens changer includes an objective lens carrier moveably attached to a changer frame by a mechanical link arrangement. The objective lens carrier includes two or more objective lens positions. The mechanical link arrangement includes a first link section to provide translation of the objective lens carrier between the objective lens positions and a second link section arranged to control an alignment of the objective lens position with respect to the optical axis of the optical instrument.

Abstract: The invention relates to a thermal barrier coating removal method. A metal component (32) having a thermal barrier coating is located in a vessel (12) for containing an inert liquid reservoir. The vessel (12) has a releasably sealable closure (14) so as to allow the vessel interior to be maintained at an elevated pressure in use. The vessel is heated and the liquid therein is maintained at a temperature greater than 100° C. for an extended period of time such that thermal barrier coating breaks up as a result of internal stress caused by a crystal structure change in the thermal barrier coating.

Abstract: A multi-tray cabinet includes a cabinet body defining an interior compartment and a compound opening thereto formed by first and second openings merging and in an angular relationship with one another, first and second doors located on the cabinet body adjacent and at an angle relative to one another and being mounted to the cabinet body to undergo movement relative to one another and to the cabinet body in order to correspondingly open and close the first and second openings, pairs of opposing of tray support members attached in a vertically spaced relationship from one pair to another on a pair of opposite interior surfaces of the cabinet body and being aligned with the first opening, and a plurality of trays on respective opposing pairs of tray support members being insertable upon and removable from the tray support members through the first opening.

Abstract: A surgical cleaning tool and method of cleaning a surgical tool. The surgical cleaning tool includes a shaft, a handle and an end portion. The shaft has a distal end and a proximal end. The handle is attached to the distal end of the shaft The end portion is connected to the proximal end of the shaft, wherein the end portion has an outer surface, an inner cavity, an inner surface, at least one cleaning element connected to at least a portion of the inner surface, and an opening in a wall portion of the end portion, wherein the opening allows access to the cleaning element in the inner cavity of the end portion.

Abstract: A method includes outputting, by an information system of a vehicle, for display at a first portion of a display device located at a center console of the information system, a first graphical user interface (GUI) associated with an active application from a plurality of applications. The method includes determining, by the information system, respective relevancy scores of two or more applications from the plurality of applications other than the active application. Each respective relevancy scores indicates a probability that the application will be of interest to a driver of the vehicle while the first GUI is being output for display. The method includes determining, by the information system, based on the respective relevancy scores, a highest ranked application from the two or more applications, and outputting, by the information system, for display at a second portion of the display device, a second GUI associated with the highest ranked application.

Abstract: A ceiling fan includes an annular nozzle having an inner wall, an outer wall extending about the inner wall, an air inlet for receiving an air flow, an air outlet for emitting the air flow, and an interior passage located between the inner and outer wall for conveying the air flow to the air outlet. The inner wall defines a bore through which air from outside the nozzle is drawn by the air flow emitted from the air outlet. A support assembly supports the nozzle on a ceiling and includes a ceiling mount for mounting the ceiling fan on a ceiling, an arm having a first end connected to the ceiling mount, and a body connected to a second end of the arm and the annular nozzle. The body is pivotable relative to the arm about a pivot axis to move the annular nozzle between a raised and lowered position.

Abstract: A fan assembly for generating an air flow within a room includes an annular casing which defines an interior passage. The interior passage includes an air inlet, and houses, downstream from the air inlet, an impeller and a motor for driving the impeller to draw an air flow through the air inlet and into the fan assembly. The interior passage also has an air outlet from which at least a portion of the air flow is emitted from the fan assembly. The annular casing defines a bore about which the interior passage extends and through which a secondary air flow from outside the fan assembly is drawn by the air emitted from the air outlet.

Abstract: Methods, articles of manufacture, and devices related to generating six degree of freedom (DOF) haptic feedback are provided. A computing device can receive first depth data about an environment. The computing device can generate a first plurality of points from the first depth data. The computing device can determine a virtual tool, where the virtual tool is specified in terms of a translation component for the virtual tool and a rotation component for the virtual tool. The computing device can determine a first force vector between the virtual tool and the first plurality of points. The computing device can send a first indication of haptic feedback based on the first force vector.

Abstract: The invention provides comprehensive and comparative flow cytometry-based methods for characterizing the state of a biological system by determining cell phenotypes and associated gene expression profiles.

Abstract: Apparatus and methods for defining and utilizing virtual fixtures for haptic navigation within real-world environments, including underwater environments, are provided. A computing device can determine a real-world object within a real-world environment. The computing device can receive an indication of the real-world object. The computing device can determine a virtual fixture that corresponds to the real-world object based on the indication, where aspects of the virtual fixture are configured to align with aspects of the real-world object. The computing device can provide a virtual environment for manipulating the robotic tool to operate on the real-world object utilizing the virtual fixture. The virtual fixture is configured to provide haptic feedback based on a position of a virtual robotic tool in the virtual environment that corresponds to the robotic tool in the real-world environment.

Abstract: The present invention provides a wood preservative formulation comprising an isothiazolone, an organic fungicidal timber decay preservative and an unsaturated carboxylic or sulphonic acid, salt or anhydride thereof. The formulations of the invention are surprisingly effective at protecting wood and other cellulosic substrates, in particular at providing prolonged protection against in-service surface staining. The invention also provides methods for treating wood and other cellulosic substrates with said formulations.

Abstract: A method of making a skate boot including manufacturing a rear element including a tendon guard for covering at least a rear portion of the ankle received within the boot, and forming a direct connection at a fixed position between contacting portions of the rear element and of a remainder of the skate boot separately from the quarters, the direct connection being formed such that the rear element is an external element of the boot and such that an upper portion of the rear element is displaceable relative to the quarters in a forward and rearward direction, the upper portion of the rear element being displaceable through flexing of the rear element about the connection.

Abstract: A food composition comprising pulverized corn germ and a fat source is described herein. The germ is derived from an isolated germ source that has not been derived from a wet milling process or extracted with organic solvent. The composition may have a paste form, which may be spreadable or flowable. The composition may include a vitamin and/or a mineral supplement, preferably from natural sources. Colorings and flavorings may be added. Cocoa may be added. The composition can be used in place of peanut butter or other spreads made with priority allergens, and thus can be used in institutional settings that have banned peanut and tree nut products. Methods of formulating the composition, as well as uses therefor, such as in confectionery, are described. The composition may be associated with health benefits.

Abstract: A fan assembly for generating an air flow within a room includes an impeller and a motor for driving the impeller to draw an air flow into the fan assembly, and a casing having an interior passage with a scroll section having a cross-sectional area that decreases from a scroll inlet section to a scroll outlet section. The scroll inlet section has an inlet port for receiving the air flow and the scroll outlet section has an outlet port for returning a first portion of the air flow to the scroll inlet section. The scroll section includes an air outlet for emitting a second portion of the air flow from the casing. The casing defines a bore through which air from outside the fan assembly is drawn by the air emitted from the air outlet.

Abstract: There is disclosed a temperature indicator (10) in the form of a substrate (12) with multiple coating layers (14-22). Each coating layer (14-22) is visually or chemically distinct from the substrate (12). The material makeup of each coating layer (14-22) is different such that each coating is tailored to undergo failure at a different temperature. The presence or absence of coating layers (14-22) can provide a lasting visual indication of a temperature experienced by the indicator (10) in use. The temperature indicator (10) may be beneficial where the use of conventional temperature sensors is problematic, such as within reactor vessels or other sealed enclosures.

Abstract: A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and compositions, as well as methods for the use thereof to inhibit cytokine signaling.

Abstract: Objective lens changer comprising: a changer frame arranged to be positioned with respect to the optical path of an optical apparatus, an objective lens carrier moveably attached to the frame by a mechanical link arrangement, the objective lens carrier comprising at least two objective lens positions that can be selectively positioned in the optical path by the mechanical link arrangement, wherein the mechanical link arrangement comprises a first link section to provide translation of the objective lens carrier between the objective lens positions and a second link section spaced apart from the first link section in the direction of the optical axis, and arranged to control the alignment of the objective lens position positioned in the optical path with respect to the optical axis, and wherein the mechanical link arrangement is arranged to move the objective lens carrier in one plane and so that the translation between the objective lens positions involves both an angular movement and a linear movement of the

Abstract: Described is a fan assembly comprising a body comprising an inlet, an outlet, and a means for generating an air flow through the body. The fan assembly also comprises a nozzle mountable on the body for receiving the air flow from the body and for emitting the air flow, wherein the body and the nozzle have cooperative inclined surfaces configured to assist alignment of the nozzle on the body.

Abstract: A cover system for a load bed of a vehicle having a winding shaft mounted rotatably in a support structure, a flexible flat structure mounted on the winding shaft for winding up and unwinding between a rest position and a covering position and connected to a pull-out profile on its front end region remote from the winding shaft. Two guide rail arrangements are provided on opposite sides of the flat structure in which guide rail arrangements the pull-out profile is guided. Each guide rail arrangement has a hollow profile provided with a plurality of cavities which run along the hollow profile, are open or closed toward the flat structure and have guiding or receiving functions for the pull-out profile of the flat structure and a drive transmission.