Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: The present invention provides compositions and methods for reducing inflammation. In one aspect, the present invention provides a protein inhibitor comprising an ectodomain of at least one TREM or TREML protein. The invention also relates to inhibiting the interaction between a TREM or TREML protein and mitochondria released or derived from necroptotic cells; or between a TREM or TREML protein and cardiolipin.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: Described herein are functionalized cells comprising an immune checkpoint molecule covalently attached to the cell surface or to a nanoparticle attached to the cell surface, and compositions comprising the functionalized cells. Also described are acellular pancreatic extracellular matrices comprising a functionalized cell(s) and decellularized pancreatic-derived protein(s). Also described are methods of treating disease by administering to subjects the functionalized cells and acellular pancreatic extracellular matrices. Also described are methods of making the functionalized cells and acellular pancreatic extracellular matrices described herein.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: A computer-implemented method of monitoring security of a set of computing devices in a distributed system, the distributed system having a plurality of computing devices, in communication with one another over a network, by a security software running in a computer node. The method includes comparing an app signature of the application running in a selected one of the set of computing devices to a reference app signatures generated from a respective functional replica of the application.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: Under Backend Application Session Management (“BASM”), a DBMS not only creates an application session but also the respective adjunct security context to which to attach the adjunct security context. The middle tier does not need to create the application session or its adjunct security context. Instead, the middle tier sends an end-user token that the middle tier piggybacks to database requests that are sent through database connections. The end-user token identifies an end user and has been authenticated by the middle tier. The generation of the end-user token is concomitant to the process of the middle tier authenticating the end user. The DBMS invokes a user-defined function to generate an adjunct security context. The user-defined function generates the adjunct security context based on the end-user token. Application developers can customize the user-defined function to customize backend security for their needs.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least one first targeting agent which binds a first target on an NK cell surface, and at least one second targeting agent which binds a second target on a cancer cell surface, wherein the second targeting agent is different from the first targeting agent.

Abstract: Disclosed herein are antigen-capturing nanoparticles. Specifically, the subject matter contained herein pertains to novel nanoparticles that can capture a multitude of tumor antigens that are released from tumor cells. Also, provided herein are methods for preparing the antigen-capturing nanoparticles and methods for the treatment of disease in a subject comprising administering the antigen-capturing nanoparticles.

Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: The disclosure includes compounds of Formula (I): wherein R1, R2, and R3, are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: A computer-implemented method of monitoring security of a set of computing devices in a distributed system, the distributed system having a plurality of computing devices, in communication with one another over a network, by a security software running in a computer node. The method includes comparing an app signature of the application running in a selected one of the set of computing devices to a reference app signatures generated from a respective functional replica of the application.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: A control device to provide control of electrical devices based on timing information. The control device stores device operational information which indicates an association between timing information and a plurality of operational modes for each of a set of electrical devices associated with a physical space. The control device detects a presence of a user within the physical space. The user is associated with an electronic apparatus. The control device further compares other timing information captured at a time of the detection of the presence of the user with the timing information. The control device determines an operational mode from the plurality of operational modes for each of the set of electrical devices based on the comparison. The control device further controls each of the set of electrical devices based on the determined operational mode.

Abstract: The present invention provides compositions and methods for reducing inflammation. In one aspect, the present invention provides a protein inhibitor comprising an ectodomain of at least one TREM or TREML protein. The invention also relates to inhibiting the interaction between a TREM or TREML protein and mitochondria released or derived from necroptotic cells; or between a TREM or TREML protein and cardiolipin.

Abstract: The invention uses a PID controller engine to provide a desired distribution of targeted ad placements, including controlling campaign pace in realtime to precisely spend a campaign budget over a prescribed runtime, while producing optimum results in a cost efficient manner based on desired targeting parameters. Those parameters include one or more probabilities that a viewer associated with an ad impression opportunity: belongs to one or more targeted demographic categories; will convert with respect to a product or service being offered; has an intention to buy the product or service; or exhibits one or more defined behaviors. Probabilities are determined by a truth-based machine-learning modelling engine. Upon receiving an ad slot opportunity package, a DSP makes a bid decision and determines a bid price, and then sends a bid response to the supply-side partner, all within 200 mS of receiving the ad slot opportunity or the bid will be ignored.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: A computer-implemented method designs a distributed heterogeneous computing and control system, including both an application and a hardware context and configuring the application in the hardware context. The method is implemented by design software instructions executing in a computer node, associated with an interactive display, to establish an interactive environment utilizing computer processes. The computer processes provide access in the interactive environment to a set of functional modules and a set of primitive modules. The computer processes receive the interactive environment a selection of desired ones of the functional modules and the primitive modules and order them in a manner to characterize the distributed computing and control system as a schematic of a set of devices. The computer processes parse the schematic to produce a set of sub-schematics that each correspond to a distinct device in a set of devices in the distributed computing and control system.