Abstract: Techniques for discovering primary, unique, and/or foreign keys for relational datasets are described. The techniques include profiling the relational datasets to obtain respective data profiles; identifying one or more primary key candidates for a first relational dataset using a first data profile of the first relational dataset and a first trained machine learning model; identifying one or more foreign key proposals for a second relational dataset using the one or more primary key candidates by performing a subset analysis of the second relational dataset with respect to the first relational dataset; identifying one or more foreign key candidates for the second relational dataset using the first data profile, a second data profile of the second relational dataset, and a second trained machine learning model different from the first trained machine learning model; and outputting the at primary key candidate(s) and the foreign key candidate(s).

Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: Methods and systems for designing dental appliances are provided. In some embodiments, a method includes identifying one or more intended outcomes for one or more areas of a dental appliance, where the dental appliance is shaped to receive and engage with a person's dentition in accordance with a treatment plan; identifying one or more acceptability criteria for evaluating compliance with the one or more intended outcomes; obtaining an appliance model for the dental appliance, where the appliance model represents the one or more areas with one or more first physical properties conforming to the one or more acceptability criteria, and where the one or more first physical properties are different than one or more second physical properties outside the one or more areas; providing three-dimensional (3D) printing instructions to generate the dental appliance using the appliance model; and 3D printing the dental appliance using the 3D printing instructions.

Abstract: An apparatus and method for closed loop dynamic resource allocation.

Abstract: An electronic device can include a housing, an audio component, and a gasket. The housing can define a first internal volume and the audio component can define a second internal volume. The audio component can include membrane and a venting element having a fluid impermeable layer. The venting element can define a fluid path placing the first internal volume and the second internal volume in fluid communication. At least a portion of the fluid path can extend parallel to the fluid impermeable layer. The gasket can define a seal between the first internal volume and an ambient environment adjacent the housing.

Abstract: A system architecture for linking one or more derived objects to existing data objects in a data structure can be organized in a variety of forms. A method for establishing the architecture may include linking first and second data objects, linking first and second data objects. The first and second data objects may be associated with corresponding first and second pluralities of properties. The method may include receiving a first user limitation associated with at least one of the first or second pluralities of properties and receiving a second user limitation associated with at least one of the first or second pluralities of properties. The method can include deriving a conclusion object comprising a third plurality of properties comprising a subset of one or more of the first or second pluralities of properties and linking the conclusion object to the first and second data objects.

Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2? breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.

Abstract: In some embodiments, a method receives a plurality of pull notification options at an application. The method determines whether to perform a ranking of the plurality of pull notification options at the application. When the ranking is be performed at the application: ranking the plurality of pull notification options; and outputting the plurality of pull notification options for display on the application based on the ranking. A pull notification option in the plurality of pull notification options is associated with information to cause an associated contact option to be contacted upon selection of the pull notification option. When the ranking is not to be performed by the application, the method outputs the plurality of pull notification options for display on the application.

Abstract: The present disclosure pertains to compositions comprising aflibercept and methods for producing such compositions in chemically defined media and using chromatography to reduce certain aflibercept variants.

Abstract: The present invention provides compositions and methods for reducing inflammation. In one aspect, the present invention provides a protein inhibitor comprising an ectodomain of at least one TREM or TREML protein. The invention also relates to inhibiting the interaction between a TREM or TREML protein and mitochondria released or derived from necroptotic cells; or between a TREM or TREML protein and cardiolipin.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: Described herein are functionalized cells comprising an immune checkpoint molecule covalently attached to the cell surface or to a nanoparticle attached to the cell surface, and compositions comprising the functionalized cells. Also described are acellular pancreatic extracellular matrices comprising a functionalized cell(s) and decellularized pancreatic-derived protein(s). Also described are methods of treating disease by administering to subjects the functionalized cells and acellular pancreatic extracellular matrices. Also described are methods of making the functionalized cells and acellular pancreatic extracellular matrices described herein.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least two different targeting agents that each bind a different protein receptor on a T cell surface.

Abstract: A computer-implemented method of monitoring security of a set of computing devices in a distributed system, the distributed system having a plurality of computing devices, in communication with one another over a network, by a security software running in a computer node. The method includes comparing an app signature of the application running in a selected one of the set of computing devices to a reference app signatures generated from a respective functional replica of the application.

Abstract: A computer-implemented method characterizes and controls performance of a set of device nodes in a distributed heterogeneous computing and control system. The device nodes are in physically distinct locations, in communication with one another over a network. One or more of the device nodes require different application programming code due to differences in hardware configuration or software configuration. The method includes configuring, by a design computer, for introduction into each distinct one of the device nodes, a corresponding communication facility and a corresponding dashboard instance. After introduction of the communication facility and dashboard instance into each device node, the design computer includes a communication facility in communication with the corresponding communication facility of each device node.

Abstract: Under Backend Application Session Management (“BASM”), a DBMS not only creates an application session but also the respective adjunct security context to which to attach the adjunct security context. The middle tier does not need to create the application session or its adjunct security context. Instead, the middle tier sends an end-user token that the middle tier piggybacks to database requests that are sent through database connections. The end-user token identifies an end user and has been authenticated by the middle tier. The generation of the end-user token is concomitant to the process of the middle tier authenticating the end user. The DBMS invokes a user-defined function to generate an adjunct security context. The user-defined function generates the adjunct security context based on the end-user token. Application developers can customize the user-defined function to customize backend security for their needs.

Abstract: The present invention provides methods and compositions comprising a particle comprising at least one first targeting agent which binds a first target on an NK cell surface, and at least one second targeting agent which binds a second target on a cancer cell surface, wherein the second targeting agent is different from the first targeting agent.

Abstract: Disclosed herein are antigen-capturing nanoparticles. Specifically, the subject matter contained herein pertains to novel nanoparticles that can capture a multitude of tumor antigens that are released from tumor cells. Also, provided herein are methods for preparing the antigen-capturing nanoparticles and methods for the treatment of disease in a subject comprising administering the antigen-capturing nanoparticles.

Abstract: In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

Abstract: The disclosure includes compounds of Formula (I): wherein R1, R2, and R3, are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.