Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: A computer implemented method includes allocating to an advertisement campaign, planned bookings for certain time periods and for certain digital displays from an Out Of Home inventory. The method also allocates, by a real-time bidding process, unplanned bookings to the time periods. Forecasts of unplanned bookings demand are taken into account in allocating planned bookings.

Abstract: Systems and methods for mutual authentication of a user and a container administrator computer system. A container administrator computer system receives a request from a mobile computing device for a user to access a secure container. The request includes a user identifier. The administrator system receives a first authentication factor corresponding to the user. The administrator system authenticates the user by verifying that the first authentication factor matches a first reference authentication factor associated with the user identifier. The administrator system sends a second authentication factor associated with the administrator system to a human-machine interface associated with the secure container or the mobile computing device. The administrator system receives a notification of authentication of the administrator system using the authentication factor. The administrator system transmits an unlock signal to unlock the secure container.

Abstract: Ultrasound imaging is a non-invasive, non-radioactive, and low cost technology for diagnosis and identification of implantable medical devices in real time. Developing new ultrasound activated coatings is important to broaden the utility of in vivo marking by ultrasound imaging. Ultrasound responsive macro-phase segregated micro-composite thin films were developed to be coated on medical devices composed of multiple materials and with multiple shapes and varying surface area. The macro-phase segregated films having silica micro-shells in polycyanoacrylate produces strong color Doppler signals with the use of a standard clinical ultrasound transducer. Electron microscopy showed a macro-phase separation during slow curing of the cyanoacrylate adhesive, as air-filled silica micro-shells were driven to the surface of the film. The air sealed in the hollow space of the silica shells acted as an ultrasound contrast agent and echo decorrelation of air exposed to ultrasound waves produces color Doppler signals.

Abstract: Example embodiments involve a metrics collection system for collecting software usage metrics from one or more client devices at deployments. A computer, such as a server configured to execute the metrics collection system, collects software usage metrics (e.g., as a metrics submission from a client device) of the software product at the deployment, identifies a metrics type of the software usage metrics collected, assigns the software usage metrics to a metrics category, and calculates and updates a metrics score of the metrics category, based on the software usage metrics collected.

Abstract: A method includes receiving a DNS request, notifying a serverless orchestrator system of data associated with the DNS request, provisioning a function on a serverless function node based on the DNS request, notifying a load balancer regarding the serverless function node, providing a response to the DNS request and routing an API request associated with the DNS request to the serverless function node.

Abstract: An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

Abstract: A thermal management system for controlling cooling of an engine system during shutdown, the engine system includes an engine configured to provide power to a working machine, wherein the thermal management system includes a controller which is configured to receive a signal indicative of an engine shutdown command. The controller is further configured to derive, infer or receive a temperature parameter of the engine system and to determine whether the temperature parameter of the engine system is above a first predetermined threshold; and wherein the controller is configured to signal the progressive reduction of a speed of the engine prior to issuing a signal to shutdown the engine in the event that the first predetermined threshold is exceeded when the engine shutdown command is received, thereby cooling the engine system prior to engine shutdown.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: Systems and methods for displaying electronic messages are disclosed. In one aspect, a method is performed at a computing device. The method includes: (1) receiving a plurality of electronic messages; (2) assigning a first subset of the messages to a predefined group category based on a set of content-based clustering rules and content in respective bodies of the messages; (3) concurrently displaying a second subset of the messages and a cluster graphic corresponding to the predefined group category, where the cluster graphic includes a label that describes the predefined group category; (4) while concurrently displaying the second subset of electronic messages and the cluster graphic, receiving user selection of the cluster graphic; and (5) in response, displaying a plurality of messages in the predefined group category, including displaying at least one message from the first subset of messages.

Abstract: An electronic construction collaboration system for managing a construction project is provided. The electronic construction collaboration system includes an Enterprise Resource Planning (ERP) sub-system including a contract engine configured to generate at least one project contract including a contract data set and ERP metadata corresponding to Building Information Modeling (BIM) metadata included in a structural object of a construction project model in a BIM sub-system and an interconnection engine configured to associatively link the ERP metadata and the BIM metadata and send the contract data set to the BIM sub-system in response to associatively linking the ERP metadata and the BIM metadata.

Abstract: A system for interleaving substrate under food products is provided. The system includes an interleaver assembly configured to interleave substrate with food products. A programmable logic controller (PLC) includes a sensor in communication with the interleaver assembly. The sensor is configured to detect an identifier provided on each substrate stock of a plurality of substrate stocks, and each identifier is associated with an interleaving profile. The interleaver assembly interleaves the substrate with the food product according to a specific interleaving profile in response to the sensor detecting the identifier on the substrate stock.

Abstract: A system and method for controlling flow of air into an air compressor of an air compressor system includes a proportional solenoid valve configured to control flow of supply air into the air compressor in proportional response to sensed air pressure generated by the air compressor system.

Abstract: Systems and methods for displaying electronic messages are disclosed. In one aspect, a method is performed at a computing device. The method includes: (1) receiving a plurality of electronic messages; (2) assigning a first subset of the messages to a predefined group category based on a set of content-based clustering rules and content in respective bodies of the messages; (3) concurrently displaying a second subset of the messages and a cluster graphic corresponding to the predefined group category, where the cluster graphic includes a label that describes the predefined group category; (4) while concurrently displaying the second subset of electronic messages and the cluster graphic, receiving user selection of the cluster graphic; and (5) in response, displaying a plurality of messages in the predefined group category, including displaying at least one message from the first subset of messages.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: A system and method for a virtual processor base/virtual execution context arrangement. The disclosed arrangement utilizes chiplets comprising core logic and defined instruction sets. The chiplets are adapted to operate in conjunction with one or more active execution contexts to enable the execution of particular processes. In particular, the defined instruction sets includes a instructions for processor debugging. The system and method support the compartmentalization of such debugging instructions so as to provide enhanced processor and process security.

Abstract: A system and method for the storage within one or more virtual execution context registers private code representative of processes or other information requiring an enhanced degree of security. The storage of the private code can be performed as a function of the type of code or in response to one or more markers embedded within the code. The time-variant nature of the virtual execution context registers affords a high degree of inherent security for the private code data stored within.

Abstract: A split cycle internal combustion engine comprising a compression cylinder accommodating a compression piston; a combustion cylinder accommodating a combustion piston; a crossover passage between the compression cylinder and the combustion cylinder arranged to provide working fluid to the combustion cylinder; a controller arranged to determine a peak temperature of combustion in the combustion cylinder based on a received indication of a peak temperature of combustion in the combustion cylinder; and a coolant system arranged to regulate a temperature of the working fluid supplied to the combustion cylinder; wherein, in response to determining that the peak temperature of combustion exceeds a selected threshold, the controller is configured to control the coolant system to regulate the temperature of the working fluid supplied to the combustion cylinder so that a peak temperature of combustion in the combustion cylinder is less than the selected threshold.

Abstract: Systems and methods for displaying electronic messages are disclosed. In one aspect, a method is performed at a computing device. The method includes: (1) receiving a plurality of electronic messages; (2) assigning a first subset of the messages to a predefined group category based on a set of content-based clustering rules and content in respective bodies of the messages; (3) concurrently displaying a second subset of the messages and a cluster graphic corresponding to the predefined group category, where the cluster graphic includes a label that describes the predefined group category; (4) while concurrently displaying the second subset of electronic messages and the cluster graphic, receiving user selection of the cluster graphic; and (5) in response, displaying a plurality of messages in the predefined group category, including displaying at least one message from the first subset of messages.

Abstract: The present invention generally relates to systems, methods and program products for use with Exchange-Traded Funds (“ETF”) holding one or more secured notes backed by one or more precious metals.