Abstract: The present invention generally relates to systems, methods and program products for use with Exchange-Traded Funds (“ETF”) holding one or more secured notes backed by one or more precious metals.

Abstract: This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.

Abstract: A system and method for controlling flow of air into an air compressor of an air compressor system includes a proportional solenoid valve configured to control flow of supply air into the air compressor in proportional response to sensed air pressure generated by the air compressor system.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Provided herein are methods of forming immune complexes for analyzing immunity against a specific antigen or pathogen in an immunized or infected subject. The methods entail isolating polyclonal immunoglobulin (Ig) molecules from a blood or serum sample from an immunized or infected subject, enzymatically digesting the polyclonal Ig molecules to generate Fab molecules, and contacting the Fab molecules with a soluble pathogen and/or antigen of interest, and identifying one or more immune complexes formed between the pathogen and/or antigen and the Fab molecules.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: A quasi-sinusoidal variable capacitor, comprising a stator and a rotor, is disclosed. Its stator and rotor are housed within a vacuum chamber. The stator is fixedly attached to a non-conductive stator mount within the vacuum chamber. The stator includes at least two sub-assemblies of stator pole plates. These stator pole sub-assemblies are electrically isolated from one another, whereas the sub-assemblies' stator plates are in electrical communication with one another. The rotor, through a rotor shaft, is rotatably coupled to the stator mount. The rotor includes a non-conductive rotor mount and conductive rotor segments. The rotor segments are evenly spaced around and fixedly attached to the rotor mount. These rotor segments are electrically isolated from one another. Electrical charge within the stator's capacitance causes electrostatic induction within these rotor segments.

Abstract: Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.

Abstract: A split cycle internal combustion engine comprising a compression cylinder accommodating a compression piston; a combustion cylinder accommodating a combustion piston; a crossover passage between the compression cylinder and the combustion cylinder arranged to provide working fluid to the combustion cylinder; a controller arranged to determine a peak temperature of combustion in the combustion cylinder based on a received indication of a peak temperature of combustion in the combustion cylinder; and a coolant system arranged to regulate a temperature of the working fluid supplied to the combustion cylinder; wherein, in response to determining that the peak temperature of combustion exceeds a selected threshold, the controller is configured to control the coolant system to regulate the temperature of the working fluid supplied to the combustion cylinder so that a peak temperature of combustion in the combustion cylinder is less than the selected threshold.

Abstract: A system and method for the dynamic, run-time configuration of logic core register files, and the provision of an associated execution context. The dynamic register files as well as the associated execution context information are software-defined so as to be virtually configured in random-access memory. This virtualization of both the processor execution context and register files enables the size, structure and performance to be specified at run-time and tailored to the specific processing, instructions and data associated with a given processor state or thread, thereby minimizing both the aggregate memory required and the context switching time. In addition, the disclosed system and method provides for processor virtualization which further enhances the flexibility and efficiency.

Abstract: A split cycle internal combustion engine comprising a compression cylinder accommodating a compression piston; a combustion cylinder accommodating a combustion piston; a crossover passage between the compression cylinder and the combustion cylinder arranged to provide working fluid to the combustion cylinder; a controller arranged to determine a peak temperature of combustion in the combustion cylinder based on a received indication of a peak temperature of combustion in the combustion cylinder; and a coolant system arranged to regulate a temperature of the working fluid supplied to the combustion cylinder; wherein, in response to determining that the peak temperature of combustion exceeds a selected threshold, the controller is configured to control the coolant system to regulate the temperature of the working fluid supplied to the combustion cylinder so that a peak temperature of combustion in the combustion cylinder is less than the selected threshold.

Abstract: A system and method for the storage, within one or more virtual execution context registers, tracing information indicative of process/code flow within a processor system. This stored information can include a time stamp, information indicative of where the instruction pointer of the system was pointing prior to any process discontinuity, information indicative of where the instruction pointer of the system was pointing after any process discontinuity, and the number of times a specific instruction or sub-process is executed during a particular process. The data collected and stored can be utilized within such a system for the identification and analysis of processing hot-spots.

Abstract: A system and method for rolling planar food products that rest upon interleaving paper is provided. The system includes first and second conveyors, a rotating mechanism and a movement system. The rotating mechanism is normally disposed at a first position proximate to the end of the first conveyor such that a leading edge of planar dough that extends over the first conveyor falls with respect to the rotating mechanism. The controller urges rotation of the rotation mechanism as the leading edge extends with respect to the rotating mechanism and rotates until the planar food product is fully rolled about the rotation mechanism. The movement mechanism then translates the rotation mechanism to a position where it is aligned with the second conveyor.

Abstract: Systems and methods for displaying electronic messages are disclosed. In one aspect, a method is performed at a computing device. The method includes: (1) receiving a plurality of electronic messages; (2) assigning a first subset of the messages to a predefined group category based on a set of content-based clustering rules and content in respective bodies of the messages; (3) concurrently displaying a second subset of the messages and a cluster graphic corresponding to the predefined group category, where the cluster graphic includes a label that describes the predefined group category; (4) while concurrently displaying the second subset of electronic messages and the cluster graphic, receiving user selection of the cluster graphic; and (5) in response, displaying a plurality of messages in the predefined group category, including displaying at least one message from the first subset of messages.

Abstract: A system and method for virtual processor customization based upon the particular workload placed upon the virtual processor by one or more execution contexts within a given program or process. The customization serves to optimize the virtual processor architecture based upon a determination as to the size and/or type or virtual execution registers optimally suited for supporting a given execution context. This results in a time-variant processor architecture comprised of a virtual processor base and a virtual execution context.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.