Abstract: Systems and methods for managing input/output operations of a first computing system at a second computing system are disclosed. One method includes receiving an input/output control block at a distributed input/output processor separate from a first computing system, the input/output control block built by the first computing system in response to initiation of an input/output operation at the first computing system. The method also includes enqueueing an input/output operation at the distributed input/output processor, and processing, by the distributed input/output processor, the input/output operation from memory of the first computing system. The method includes returning results from the distributed input/output processor to the first computing system.

Abstract: Systems and methods for continuous computing are disclosed. One such system includes a plurality of communicatively interconnected computing systems, and a workload including a plurality of tasks executing on a first computing system of the plurality of communicatively interconnected computing systems. The system includes a task management system executing on at least one of the plurality of communicatively interconnected computing systems, the task management component configured to encapsulate a task of the plurality of tasks with a current system state of the first computing system, wherein encapsulating the task includes associating metadata defining an association between the task and resources of the first computing system. The task management system is configured to transfer the encapsulated task to a second computing system among the plurality of communicatively interconnected computing systems for execution, the metadata used to associate the task with resources of a second computing system.

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).

Abstract: System and methods are provided for receiving selection, by a user, of a subset of message clusters in a plurality of message clusters. Each message cluster is associated with a corresponding set of clustering rules. Each respective electronic message, addressed to and/or from the user, in a plurality of electronic messages is assigned to one or more of the clusters in the subset of clusters in accordance with the sets of clustering rules associated with the subset of clusters. The set of clustering rules for a first cluster in the subset of clusters (i) prevents some messages in the plurality of messages from being assigned to the first cluster and (ii) assigns messages to the first cluster without regard to content relatedness between messages in the plurality of messages and messages already in the first cluster. Messages in the first cluster are formatted for display as a single cluster graphic.

Abstract: Systems and methods for categorizing objects in accordance with one or more user categorization actions are disclosed. In some embodiments, the occurrence of one or more categorization actions is detected for a first object in a list of objects in a messaging application. Categorization actions include starring the object, dragging and dropping an object from one cluster to another, adding a new cluster label, and providing filtering rules for an object. Then a set of properties for the first object is updated in accordance with the one or more categorization actions. The updated set of properties for the first object is compared to one or more categorization rules. For instance, an exemplary categorization rule is that a starred message is to be displayed in a primary cluster. Then information for displaying the first object in the list of objects in accordance with the one or more categorization rules is prepared.

Abstract: System and methods are provided for performing a method, for instance, at a computer system having one or more processors and memory storing one or more programs for execution by the one or more processors. In the method a search query is received. The search query identifies a message category from among a plurality of message categories. Each respective message category in the plurality of message categories corresponds to an electronic message display format in a plurality of electronic message display formats. Responsive to the search query, a search result comprising one or more electronic messages satisfying the search query is identified. The one or more electronic messages are prepared for display by formatting for display a first electronic message, in the one or more electronic messages, associated with the first message category. The formatting makes use of the electronic message display format that corresponds to the first message category.

Abstract: Systems and methods for displaying electronic messages are disclosed. In some embodiments, a method includes, at a computing device, concurrently displaying (i) a user interface object that represents a group of messages and (ii) one or more first indicia of a number of messages that have a predefined display status, in the group of messages while foregoing displaying more than one message of the group of messages. The method also includes receiving a selection of the user interface object; and, in response to receiving the selection of the user interface object, displaying messages in the group of messages. The method further includes, in accordance with displaying the messages in the group of messages, modifying the one or more displayed first indicia of the number of messages, which have the predefined display status, in the group of messages.

Abstract: The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin (SwissProt Acc. No. P60709), apolipoprotein A-IV precursor (SwissProt Acc. No. P06727); haptoglobin beta-chain consisting of residues 162-406 (SwissProt Acc. No. P00738); haemoglobin beta chain (SwissProt Acc. No. P02023); or alpha-1-antitrypsin (SwissProt Acc. No. P01009); or a decreased concentration of a protein in the diagnostic sample, compared with a sample of a control, normal human subject, the protein being plasma protease (C1) inhibitor precursor (SwissProt Acc. No. P05155); complement component 1, s sub-component (SwissProt Acc. No. P09871); butyrylcholinesterase precursor (SwissProt Acc. No. P06276); complement component C4B (SwissProt Acc. No. P01028); lumican (SwissProt Acc. No.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Systems and methods for updating firmware executing on a computing system are disclosed. One method includes building an initial stack for use by an updated firmware module, and quiescing I/O operations occurring on the computing system. The method also includes halting all but a remaining firmware module from among one or more firmware modules to be updated and that are executing on the computing system, and, with the remaining firmware module executing on the computing system, indicating to perform a firmware update. The method further includes halting execution of a partition including the remaining firmware module. The method also includes updating the remaining firmware module executing on the computing system with the updated firmware module, and initiating execution of the updated firmware module using the initial stack.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using such compounds and salts thereof.

Abstract: Methods and systems are disclosed for analyzing performance of a translated code stream executing within a central processing module. One method includes, during execution of one or more native instructions corresponding to each non-native operator in the code stream by the code execution unit, counting the occurrence of the non-native operator, determining a duration of execution of the one or more native instructions, and adding the non-native operator to a trace sequence. The method also includes, after execution of the code stream within the central processing module, generating a data file of non-native operators executed within the code stream, the data file of operators including a name of each non-native operator, an elapsed amount of time within the code execution unit that the one or more native operators corresponding to the non-native operator are executed, and a number of occurrences of the non-native operator within the code stream.

Abstract: Systems and methods for presenting electronic messages are provided. In some implementations, a method includes, at a computing device having one or more processors and memory storing one or more programs for execution by the one or more processors, (A) causing to be concurrently displayed in an E-mail application (i) a first view of a message folder that includes one or more electronic messages and (ii) a user interface control indicating one or more alternate views are available for the message folder, wherein the user interface control persistently indicates the availability of the one or more alternative views and (B) hiding the user interface control, without user intervention, responsive to the occurrence of a predetermined system event.

Abstract: A monolithically integrated, tunable semiconductor laser with an optical waveguide, comprising epitaxial layers on a substrate and having first and second reflectors bounding an optical gain section and a non-driven region, wherein at least one of the reflectors is a distributed Bragg reflector section configured to have a tunable reflection spectrum, wherein control electrodes are provided to at least the optical gain section, and the distributed Bragg reflector section, and wherein the non-driven region has a length of at least 100 ?m, is without an electrical contact directly contacting onto the epitaxially grown side of the non-driven region, and the non-driven region is without a reflective Bragg grating within the epitaxial layers of the non-driven region.

Abstract: The invention identifies and describes proteins that are differentially expressed in platelets resistant to anti-platelet agents such as aspirin (acetylsalicyclic acid) compared to those platelets that are sensitive to such agents. Methods for determining further such differentially expressed proteins and methods for determining an individual's sensitivity to anti-platelet agents, such as aspirin, prior to administration.

Abstract: The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron micrsocopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

Abstract: The subject matter of this specification can be embodied in, among other things, a computer-implemented method including generating first instructions for presenting, on a computing device, a first view of an inbox that lists multiple electronic messages and for presenting a control, concurrently with the first view of the inbox, that indicates one or more alternate views available for the inbox. Each of the alternate views separate the electronic messages within the inbox into two or more concurrently displayed sections. The method further includes providing the first instructions to the computing device.

Abstract: Systems and methods for validating operation of a compiler are disclosed. One method includes receiving a definition of language syntax at an automated source code generator, and generating program code at the automated source code generator, the program code represented in source code including constructed self-validating code and syntactically-correct automatically generated code. The method also includes providing the source code to the compiler to be compiled into object code. Based on execution of the self-validating code as object code in a computing system, a computing system executing the object code outputs an indication of the correctness of compilation of the program code.

Abstract: Methods and systems for executing a code stream of non-native binary code on a computing system are disclosed. One method includes parsing the code stream to detect a plurality of elements including one or more branch destinations, and traversing the code stream to detect a plurality of non-native operators. The method also includes executing a pattern matching algorithm against the plurality of non-native operators to find combinations of two or more non-native operators that do not span across a detected branch destination and that correspond to one or more target operators executable by the computing system. The method further includes generating a second code stream executable on the computing system including the one or more target operators.

Abstract: Systems and methods for updating firmware executing on a computing system are disclosed. One method includes building an initial stack for use by an updated firmware module, and quiescing I/O operations occurring on the computing system. The method also includes halting all but a remaining firmware module from among one or more firmware modules to be updated and that are executing on the computing system, and, with the remaining firmware module executing on the computing system, indicating to perform a firmware update. The method further includes halting execution of a partition including the remaining firmware module. The method also includes updating the remaining firmware module executing on the computing system with the updated firmware module, and initiating execution of the updated firmware module using the initial stack.