Abstract: Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

Abstract: A method for beam management in side-link communication between User Equipment (UEs) (104) operating in a wireless communication network (100) is described. The method comprises transmitting a reference signal using at least one beam by a first UE (104-1). The first UE (104-1) receives a feedback report of the at least one beam based on the reference signal from the second UE (104-2, 104-4). The feedback report of the at least one beam comprises at least one of UE identifier (ID), beam ID, beam strength, and beam validity. The first UE (104-1) updates entries of a beam management table based on the feedback report.

Abstract: A semiconductor device includes a field effect transistor (FET). The FET includes a gate electrode in a gate layer. The gate electrode has a first gate length and a second gate length. The second gate length is greater than the first gate length. The FET also includes an active region in a active region layer. The active region includes a source region and a drain region. The active region layer is beneath the gate layer. The FET has a first channel under the gate electrode having the first gate length and between the source region and the drain region. The FET also has a second channel under the gate electrode having the second gate length and between the source region and the drain region.

Abstract: Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

Abstract: The invention relates to a curable composition including (a) a component having one or more carbonyl group-containing compounds having a number average molecular weight (Mn) of at least 500 g/mole, wherein each carbonyl group is independently a ketone group or an aldehyde group; (b) a polyamine compound having at least two primary amine groups per molecule; and (c) a polyisocyanate compound. Articles coated with the curable composition are also provided.

Abstract: The present invention relates to, a curable photochromic composition that includes: (a) a photochromic compound; (b) a hydrazide functional material having at least two hydrazide groups that are reactive with carbonyl groups selected from ketone groups and aldehyde groups; (c) a first carbonyl-functional component including a (meth)acrylate polymer having at least two carbonyl groups that are reactive with hydrazide groups; and (d) at least one of, (d1) a second carbonyl-functional component having at least one carbonyl group that is reactive with hydrazide groups, and/or (d2) a non-reactive component. The non-reactive component is free of functional groups that are reactive with the hydrazide functional material, the first carbonyl-functional component, and the second carbonyl-functional component.

Abstract: Systems and methods are described herein for generating a playlist for a simultaneous presentation of a plurality of media assets. The system retrieves a user preference associated with a user profile and receives a selection of a first media asset and a second media asset from the plurality of media assets for presentation on a user device. The system parses the respective audio streams of the first media asset and the second media asset to identify one or more preferred audio segments based on the user preference and generates the playlist of the identified one or more preferred audio segments. Based on a generated audio playlist, the system generates, for presentation on the user device, the video stream for each of the first media asset and the second media asset and the playlist of the identified one or more preferred audio segments.

Abstract: An object of the invention is to provide compounds as selective JAK1 inhibitor, a process for preparation of the inhibitors, a composition containing the compounds and utility of the compounds.

Abstract: Systems and methods are provided herein to automatically perform an action that controls the content based on analyzing a computed age difference between the viewers of the content. The system detects a first user, who is individually authorized to view the content item, and a second user, who is individually authorized to view the content item, in proximity of a media device playing a content item. The system identifys a first age of the first user and a second age of the second user and computes an age difference between the first age of the first user and the second age of the second user. The system automatically performs an action that controls the content based on analyzing the computed age difference between the first user and the second age, who are each individually authorized to view the content item.

Abstract: Disclosed herein are methods of manufacturing pyridazinone compounds useful in the treatment of Duchenne Muscular Dystrophy using Suzuki cross-coupling reactions.

Abstract: Provided are photochromic optical articles including an optical substrate and an at least partial anisotropic layer disposed on the at least a portion of the surface of the substrate. The anisotropic layer includes an anisotropic polymer; a photochromic-dichroic dye, a photochromic dye, or combination thereof; a mesogenic hindered amine light stabilizer; and a mesogenic antioxidant. Provided are photochromic coated articles including a substrate and an anisotropic coating layer on at least a portion of the surface of the substrate. The anisotropic coating layer is formed from a polymerizable composition including a polymerizable anisotropic material; a photochromic-dichroic dye, a photochromic dye, or combination thereof; a mesogenic hindered amine light stabilizer; and a mesogenic antioxidant.

Abstract: The present invention relates to curable photochromic compositions which include a polycarbodiimide, an at least di-functional first carboxylic acid functional material having at least two carboxylic acid groups, an optional second carboxylic acid functional material having at least three carboxylic acid groups, a photochromic compound, and an aprotic organic solvent. The curable photochromic compositions have an equivalents ratio of carbodiimide equivalents of the polycarbodiimide to a total carboxylic acid equivalents of the first and optional second carboxylic acid functional materials of from 0.5:1 to 10:1 when the second carboxylic acid functional material is not present; and from 0.5:1 to 3:1 when the second carboxylic acid functional material is present. The present invention, more particularly, relates to curable photochromic coating compositions, and curable photochromic adhesive compositions.

Abstract: Optionally polymerizable mesogen compounds are disclosed that include a polyvalent non-mesogenic core X to which is bonded three or four separate extensions, where each extension independently includes, in sequence, a linking group -L-, and a mesogen group—[Mesogen]. The mesogen compounds are represented by the following Formula (I), With reference to Formula (I), v is 3 or 4; t is 0 or 1; at least one Mesogen includes at least four cyclic groups; each -L- independently has an average chain length of at least 15 bonds; and at least one -L- has an average chain length of at least 25 bonds. Liquid crystal compositions are disclosed that include such mesogen compounds, and optical elements that include such mesogen compounds.

Abstract: The present invention relates to, a curable photochromic composition that includes: (a) a photochromic compound; (b) a polyisocyanate including at least two isocyanate groups; and (c) a reactive component having at least two reactive groups that are each reactive with the isocyanate groups of the polyisocyanate. Each reactive group of the reactive component is independently selected from primary amine and imine, provided that at least one reactive group of the reactive component is selected from imine. The curable photochromic composition further includes (d) a non-reactive component that is free of functional groups that are reactive with the polyisocyanate and said reactive component. The present invention also relates to an article that includes: a substrate; and a photochromic layer over at least one surface of the substrate, where the photochromic layer is formed from the curable photochromic composition of the present invention.

Abstract: Systems and methods are described herein for generating a playlist for a simultaneous presentation of a plurality of media assets. The system retrieves a user preference associated with a user profile and receives a selection of a first media asset and a second media asset from the plurality of media assets for presentation on a user device. The system parses the respective audio streams of the first media asset and the second media asset to identify one or more preferred audio segments based on the user preference and generates the playlist of the identified one or more preferred audio segments. Based on a generated audio playlist, the system generates, for presentation on the user device, the video stream for each of the first media asset and the second media asset and the playlist of the identified one or more preferred audio segments.

Abstract: Device structures and related fabrication methods for asymmetric MOSFETs that exhibit high BVDSS and low HCl characteristics while substantially improving the poor sub-threshold slope and output resistance ROUT characteristics common to conventional asymmetric MOSFET devices. Embodiments are fabricated by implanting halo and/or LDD dopants on the source-side of an asymmetric MOSFET using at least two different non-90° twist angles, each in a different quadrant. By implanting dopant at different twist angles, dopant is implanted within otherwise shadowed corners, thus essentially eliminating the parasitic transistors within such corners. Optionally, an extra implantation of halo/LDD dopants may be performed at a 90° twist angle. As a result, a non-90°, multi-twist implanted asymmetric MOSFET exhibits improved linearity and an essentially equivalent gain characteristic compared to conventional asymmetric MOSFETs. Optionally, thick spacers may be used.

Abstract: Techniques are provided comprising illuminating a camera test target according to a first light setting associated with an ambient light condition experienced by a vehicle traversing an environment; determining, based at least in part on the first image and on a known characteristic of the camera test target, a first image quality indicator; and determining, based at least in part on the first image quality indicator, a first image processor setting associated with the first light setting. Respective image processor settings can be determined for each of multiple ambient light conditions. The image processor settings may be transmitted to a vehicle controlled based at least in part on an ambient light detection associated with the environment through which the vehicle is traversing being associated with the first light setting or the second light setting.

Abstract: The present disclosure relates to limiting viewing of media content. More particularly, the present invention relates to classifying segments of content for limited viewing based on user preferences and classifications. According to a first aspect, there is provided a method for parental control of media content for a media guidance application, the method comprising, determining user preferences comprising settings for restricting viewing of segments of media content, determining media content for user consumption on a user device, determining a classification of each of a plurality of segments of the media content using a content analyzer and classifier, and comparing the determined classifications against the user preferences.

Abstract: A database management method for dynamic content adaptation for safe driving is disclosed. The method includes receiving vehicle driving data and analyzing the received vehicle driving data to determine one or more parameters pertaining to dangerous driving. Further, the method includes determining media content being played at each instance corresponding to the determined one or more parameters and fetching metadata corresponding to the determined media content. Thereafter, the method includes mapping, in a database, a type of media content based on the fetched metadata with the determined one or more parameters for dynamic content adaptation to modify and/or block media content recommendations for safe driving.

Abstract: Systems and methods are provided herein to dynamically update content restrictions for multiple users by detecting a first user in the proximity of a media device playing a first content item and detecting a second user entering the proximity of the media device. In response to detecting a second user entering the proximity of the media device and receiving a command from the first user that controls playing the first content, the system modifies a stored relationship between the first user and the second user to track the relationship between the first user and the second user. Thereafter, when the system detects the first user and the second user in the proximity of a media device playing a second content, in response, the system automatically performs an action that controls the playing of the second content (e.g., without user having to issue those commands).