Abstract: This disclosure provides crystalline polymorphs of squalamine phosphate, methods of making the same, and methods of treatment using the same.

Abstract: Systems and techniques are described herein for processing video data. For example, a process can include applying a deblocking (DB) filter to generate a DB-filtered plurality of sub-blocks with a bottom pixel row offset by a sub-block height from a bottom boundary of the block. The DB filter can be applied to a top pixel row in an additional, adjacent sub-block to generate an additional DB-filtered pixel row. A sample adaptive offset (SAO) filter applied to the DB-filtered plurality of sub-blocks can generate an SAO-filtered plurality of sub-blocks having a bottom pixel row offset from the bottom pixel row in the DB-filtered plurality of sub-blocks by the sub-block height. The SAO filter applied to the additional DB-filtered pixel row can generate an additional SAO-filtered sub-block between the bottom pixel row in the SAO-filtered plurality of sub-blocks and the bottom pixel row in the DB-filtered plurality of sub-blocks.

Abstract: Single-chip solutions that result in high capacitance and/or inductance densities. Embodiments provide relatively large capacitance and/or inductance values for applications utilizing DC and/or sub-KHz signals up to RF signals. Embodiments may include an integrated circuit having a substrate having a backside, a substructure formed on the substrate, and a superstructure formed on the substructure and having a metallization layer, the integrated circuit further including at least one backside deep trench capacitor structure including: one or more trenches formed in the backside of the substrate and lined with a first conductive layer, a dielectric, and a second conductive layer; a first electrical connection between the first conductive layer and a first portion of the metallization layer; and a second electrical connection between the second conductive layer and a second portion of the metallization layer.

Abstract: Disclosed devices, systems, and methods may enhance communication protocols for low latency applications. Systems may include a device and a host interconnected by a high-performance interconnect and/or communication link. The device may comprise a transmitter, a receiver, and a control unit that may manage a credit-based flow control mechanism. In some aspects, the device may initiate a push write request, send a data header with an identifier (UQID) matching the push write request identifier (CQID), and transmit the data payload. The host may receive the push write request, match the UQID with the CQID, perform the write operation, and send a completion message back to the device. The method may involve ensuring sufficient credits before initiating the push write transaction, which may help prevent data loss and ensure reliable delivery. The push write mechanism may reduce the number of link traversals required for device-to-host memory writes, potentially lowering overall latency.

Abstract: The present invention relates to combinations of GPR119 receptor agonists with DPP-4 inhibitors and their use thereof for treating or preventing cardiovascular and metabolic disorders, including diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), NAFL, NASH, dyslipidemia, and related disorders thereto.

Abstract: Single-chip solutions and related methods that result in much higher capacitance densities than is achievable with current on-chip solutions and which reduce consumption of planar area of a mounting structure. Embodiments of the present invention use vertical stacking to affix one or more discrete embeddable capacitors to an IC chip superstructure or base structure, and either sequentially or concurrently form electrical connections between the discrete embeddable capacitors and the IC chip. The inventive processes are compatible with CMOS fabrication temperatures for the IC chip while allowing use of capacitors that are fabricated using other processes that may involve much higher temperatures. The inventive processes allow connection of relatively large capacitances (e.g., ˜0.5 ?F-1 ?F) to an IC chip without increasing the 2-D footprint of the IC chip.

Abstract: Amplifiers with multi-tone peak detection for equalizer adaptation are described herein. An example amplifier circuit includes an amplifier, a multi-tone peak detector coupled to an output of the amplifier, a first control loop, and a second control loop. The multi-tone peak detector is configured to generate a first peak output signal and a second peak output signal based on the output of the amplifier. The first control loop is configured to generate a gain control signal for the amplifier based on the first peak output signal, and the second control loop is configured to generate an equalization control signal for the amplifier based on the first peak output signal and the second peak output signal.

Abstract: Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

Abstract: A method for beam management in side-link communication between User Equipment (UEs) (104) operating in a wireless communication network (100) is described. The method comprises transmitting a reference signal using at least one beam by a first UE (104-1). The first UE (104-1) receives a feedback report of the at least one beam based on the reference signal from the second UE (104-2, 104-4). The feedback report of the at least one beam comprises at least one of UE identifier (ID), beam ID, beam strength, and beam validity. The first UE (104-1) updates entries of a beam management table based on the feedback report.

Abstract: A semiconductor device includes a field effect transistor (FET). The FET includes a gate electrode in a gate layer. The gate electrode has a first gate length and a second gate length. The second gate length is greater than the first gate length. The FET also includes an active region in a active region layer. The active region includes a source region and a drain region. The active region layer is beneath the gate layer. The FET has a first channel under the gate electrode having the first gate length and between the source region and the drain region. The FET also has a second channel under the gate electrode having the second gate length and between the source region and the drain region.

Abstract: Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.

Abstract: The invention relates to a curable composition including (a) a component having one or more carbonyl group-containing compounds having a number average molecular weight (Mn) of at least 500 g/mole, wherein each carbonyl group is independently a ketone group or an aldehyde group; (b) a polyamine compound having at least two primary amine groups per molecule; and (c) a polyisocyanate compound. Articles coated with the curable composition are also provided.

Abstract: The present invention relates to, a curable photochromic composition that includes: (a) a photochromic compound; (b) a hydrazide functional material having at least two hydrazide groups that are reactive with carbonyl groups selected from ketone groups and aldehyde groups; (c) a first carbonyl-functional component including a (meth)acrylate polymer having at least two carbonyl groups that are reactive with hydrazide groups; and (d) at least one of, (d1) a second carbonyl-functional component having at least one carbonyl group that is reactive with hydrazide groups, and/or (d2) a non-reactive component. The non-reactive component is free of functional groups that are reactive with the hydrazide functional material, the first carbonyl-functional component, and the second carbonyl-functional component.

Abstract: Systems and methods are described herein for generating a playlist for a simultaneous presentation of a plurality of media assets. The system retrieves a user preference associated with a user profile and receives a selection of a first media asset and a second media asset from the plurality of media assets for presentation on a user device. The system parses the respective audio streams of the first media asset and the second media asset to identify one or more preferred audio segments based on the user preference and generates the playlist of the identified one or more preferred audio segments. Based on a generated audio playlist, the system generates, for presentation on the user device, the video stream for each of the first media asset and the second media asset and the playlist of the identified one or more preferred audio segments.

Abstract: An object of the invention is to provide compounds as selective JAK1 inhibitor, a process for preparation of the inhibitors, a composition containing the compounds and utility of the compounds.

Abstract: Systems and methods are provided herein to automatically perform an action that controls the content based on analyzing a computed age difference between the viewers of the content. The system detects a first user, who is individually authorized to view the content item, and a second user, who is individually authorized to view the content item, in proximity of a media device playing a content item. The system identifys a first age of the first user and a second age of the second user and computes an age difference between the first age of the first user and the second age of the second user. The system automatically performs an action that controls the content based on analyzing the computed age difference between the first user and the second age, who are each individually authorized to view the content item.

Abstract: Disclosed herein are methods of manufacturing pyridazinone compounds useful in the treatment of Duchenne Muscular Dystrophy using Suzuki cross-coupling reactions.

Abstract: Provided are photochromic optical articles including an optical substrate and an at least partial anisotropic layer disposed on the at least a portion of the surface of the substrate. The anisotropic layer includes an anisotropic polymer; a photochromic-dichroic dye, a photochromic dye, or combination thereof; a mesogenic hindered amine light stabilizer; and a mesogenic antioxidant. Provided are photochromic coated articles including a substrate and an anisotropic coating layer on at least a portion of the surface of the substrate. The anisotropic coating layer is formed from a polymerizable composition including a polymerizable anisotropic material; a photochromic-dichroic dye, a photochromic dye, or combination thereof; a mesogenic hindered amine light stabilizer; and a mesogenic antioxidant.

Abstract: The present invention relates to curable photochromic compositions which include a polycarbodiimide, an at least di-functional first carboxylic acid functional material having at least two carboxylic acid groups, an optional second carboxylic acid functional material having at least three carboxylic acid groups, a photochromic compound, and an aprotic organic solvent. The curable photochromic compositions have an equivalents ratio of carbodiimide equivalents of the polycarbodiimide to a total carboxylic acid equivalents of the first and optional second carboxylic acid functional materials of from 0.5:1 to 10:1 when the second carboxylic acid functional material is not present; and from 0.5:1 to 3:1 when the second carboxylic acid functional material is present. The present invention, more particularly, relates to curable photochromic coating compositions, and curable photochromic adhesive compositions.

Abstract: Optionally polymerizable mesogen compounds are disclosed that include a polyvalent non-mesogenic core X to which is bonded three or four separate extensions, where each extension independently includes, in sequence, a linking group -L-, and a mesogen group—[Mesogen]. The mesogen compounds are represented by the following Formula (I), With reference to Formula (I), v is 3 or 4; t is 0 or 1; at least one Mesogen includes at least four cyclic groups; each -L- independently has an average chain length of at least 15 bonds; and at least one -L- has an average chain length of at least 25 bonds. Liquid crystal compositions are disclosed that include such mesogen compounds, and optical elements that include such mesogen compounds.