Patents by Inventor Anthony P. Shuber

Anthony P. Shuber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Direct sequence identification of mutations by cleavage- and ligation-associated mutation-specific sequencing
    Patent number: 5707806
    Abstract: The present invention provides methods for identifying the presence, location and sequence of one or more genetic alterations in one or more DNA molecules. Further provided are methods for positional cloning of a gene of interest.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 13, 1998
    Assignee: Genzyme Corporation
    Inventor: Anthony P. Shuber
  • Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
    Patent number: 5670325
    Abstract: Methods are provided for detecting the presence of mutant sequences in a subpopulation of gene sequences in a biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: September 23, 1997
    Assignee: Exact Laboratories, Inc.
    Inventors: Stanley N. Lapidus, Anthony P. Shuber, Kevin M. Ulmer
  • High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides
    Patent number: 5589330
    Abstract: The present invention pertains to high-throughput screening methods to identify genetic alterations in DNA samples. A multiplicity of DNA samples are immobilized on a solid support and hybridized simultaneously with a mixture of oligonucleotides representing variant sequences. Hybridizing oligonucleotides are then eluted from each DNA sample individually and their sequence is determined. The methods of the present invention allow the identification of disease-causing mutations and polymorphisms in patients' DNA, as well as the identification of disease-causing microorganisms.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: December 31, 1996
    Assignee: Genzyme Corporation
    Inventor: Anthony P. Shuber
  • Method for mismatch-directed in vitro DNA sequencing
    Patent number: 5571676
    Abstract: The present invention relates to methods for identifying the location, and determining the sequence of specific genetic alterations present in a gene of interest.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 5, 1996
    Assignee: IG Laboratories, Inc.
    Inventor: Anthony P. Shuber