Patents by Inventor Anthony P. Shuber

Anthony P. Shuber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for disease detection
    Patent number: 6586177
    Abstract: The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: July 1, 2003
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Primer extension methods for detecting nucleic acids
    Patent number: 6566101
    Abstract: Methods are provided for selective nucleic acid sequence detection in single base primer extension reactions of high sensitivity. These methods are useful for detecting small amounts of mutant nucleic acid in a heterogeneous biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: May 20, 2003
    Inventors: Anthony P. Shuber, Stanley N. Lapidus
  • Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
    Publication number: 20030087258
    Abstract: The invention provides amplification-based methods for detecting hypermethylated nucleic acid in heterogeneous biological samples, e.g., stool. A screening procedure based on the detection of hypermethylation, preferably at multiple genes, provides a means for detecting various diseases, e.g., colorectal cancer. By using chimeric primers that contain a 5′ non-specific portion, the specificity and efficiency of the nucleic acid amplification is improved. Methods of the invention are especially useful in detection of rare events in a heterogeneous sample.
    Type: Application
    Filed: April 11, 2002
    Publication date: May 8, 2003
    Inventor: Anthony P. Shuber
  • Methods for preserving DNA integrity
    Patent number: 6551777
    Abstract: Methods for extracting DNA from a biological sample that result in a higher yield of target DNA than conventional methods. More particularly, methods for extracting DNA include exposing the biological sample to inhibitors of DNA degradation.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: April 22, 2003
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, Frederick A. Huntress, Jr., James K. Moore
  • PRIMER EXTENSION METHODS UTILIZING DONOR AND ACCEPTOR MOLECULES FOR DETECTING NUCLEIC ACIDS
    Publication number: 20030044780
    Abstract: Methods are provided for selective nucleic acid sequence detection in primer extension reactions of high specificity. These methods are useful for detecting small amounts of mutant nucleic acid in a heterogeneous biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.
    Type: Application
    Filed: November 23, 1999
    Publication date: March 6, 2003
    Inventors: STANLEY N. LAPIDUS, ANTHONY P. SHUBER
  • Methods for detecting mutations using primer extension for detecting disease
    Patent number: 6503718
    Abstract: Methods of the invention comprise assays for markers indicative of cancer, precancer, and other diseases or disorders. Assays of the invention are preformed on heterogeneous samples obtained from patients by non-invasive or minimally-invasive methods.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: January 7, 2003
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, William Pierceall, Steven J. Laken
  • Methods for detecting mutations using primer extension
    Patent number: 6482595
    Abstract: Methods for detecting nucleotide deletions in biological samples are described. Methods of the invention are particulary useful for detecting deletions in regions of polynucleotide repeats. In particular, methods of the invention are useful to detect deletions at the BAT26 locus.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: November 19, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, William Pierceall
  • Methods for stool sample preparation
    Publication number: 20020164631
    Abstract: The present invention provides methods for the preparation of stool samples to increase the yield of relevant DNA, and further provides methods for isolating and analyzing target DNA for characteristics indicative of colorectal cancer. Methods for screening patients for the presence of cancerous or pre-cancerous colorectal lesions are also provided.
    Type: Application
    Filed: March 25, 2002
    Publication date: November 7, 2002
    Inventors: Anthony P. Shuber, Stanley N. Lapidus, Gail E. Radcliffe
  • Methods for detecting mutations using primer extension for detecting disease
    Patent number: 6475738
    Abstract: Methods of the invention comprise assays for markers indicative of cancer, precancer, and other diseases or disorders. Assays of the invention are preformed on heterogeneous samples obtained from patients by non-invasive or minimally-invasive methods. Such assays may be employed alone or in combination with other disease screening techniques.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: November 5, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, William Pierceall
  • Method for alteration detection
    Publication number: 20020132251
    Abstract: Methods are provided for detecting an alteration in a target nucleic acid.
    Type: Application
    Filed: November 20, 2001
    Publication date: September 19, 2002
    Inventor: Anthony P. Shuber
  • Methods for the detection of nucleic acids
    Publication number: 20020119469
    Abstract: Methods are provided for identifying nucleic acids. Methods of the invention are usefull for identifying and analyzing nucleic acids, especially variants of single nucleotide polymorphisms, that are indicative of disease or the predisposition for disease.
    Type: Application
    Filed: October 5, 2001
    Publication date: August 29, 2002
    Inventors: Anthony P. Shuber, Stanley N. Lapidus
  • Methods for disease diagnosis from stool samples
    Publication number: 20020119472
    Abstract: The present invention provides methods for preparing a stool sample in order to screen for the presence of indicators of a disease, for example a subpopulation of cancerous or precancerous cells. The methods take advantage of the recognition that cellular debris from cancerous and precancerous cells is deposited onto only a longitudinal stripe of stool as the stool is forming in the colon. Accordingly, methods of the invention comprise obtaining a representative sample, such as a circumferential or cross-sectional sample of stool in order to ensure that any disease indicator, such as cellular debris that is shed by colonic cells, is obtained in the sample.
    Type: Application
    Filed: October 15, 2001
    Publication date: August 29, 2002
    Inventors: Stanley N. Lapidus, Anthony P. Shuber
  • Methods for detecting, grading or monitoring an H. pylori infection
    Publication number: 20020110810
    Abstract: The present invention provides methods for determining the status of an H. pylori infection by detecting a high-integrity H. pylori nucleic acid in a patient sample.
    Type: Application
    Filed: January 5, 2001
    Publication date: August 15, 2002
    Inventor: Anthony P. Shuber
  • Method for alteration detection
    Patent number: 6428964
    Abstract: Methods are provided for detecting an alteration in a target nucleic acid. Methods of the invention are useful for detecting and identifying mutations that are indicative of disease or the predisposition for disease.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: August 6, 2002
    Assignee: Exact Sciences Corporation
    Inventor: Anthony P. Shuber
  • Methods for stool sample preparation
    Patent number: 6406857
    Abstract: The present invention provides methods for the preparation of stool samples to increase the yield of relevant DNA, and further provides methods for isolating and analyzing target DNA for characteristics indicative of colorectal cancer. Methods for screening patients for the presence of cancerous or pre-cancerous colorectal lesions are also provided.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: June 18, 2002
    Assignee: Exact Sciences Corporation
    Inventors: Anthony P. Shuber, Stanley N. Lapidus, Gail E. Radcliffe
  • Methods for detecting mutations using primer extension for detecting disease
    Publication number: 20020064787
    Abstract: Methods of the invention comprise assays for markers indicative of cancer, precancer, and other diseases or disorders. Assays of the invention are preformed on heterogeneous samples obtained from patients by non-invasive or minimally-invasive methods. Such assays may be employed alone or in combination with other disease screening techniques.
    Type: Application
    Filed: June 18, 2001
    Publication date: May 30, 2002
    Inventors: Anthony P. Shuber, William Pierceall
  • METHODS FOR DETECTING LOWER-FREQUENCY MOLECULES
    Publication number: 20020048752
    Abstract: Methods are provided for detection of lower-frequency molecules in relation to and against the background of higher-frequency molecules.
    Type: Application
    Filed: November 17, 1999
    Publication date: April 25, 2002
    Inventors: STANLEY N. LAPIDUS, ANTHONY P. SHUBER
  • Methods for detecting mutations using primer extension
    Publication number: 20020045183
    Abstract: Methods for detecting nucleotide deletions in biological samples are described. Methods of the invention are particulary useful for detecting deletions in regions of polynucleotide repeats. In particular, methods of the invention are useful to detect deletions at the BAT26 locus.
    Type: Application
    Filed: August 27, 2001
    Publication date: April 18, 2002
    Inventors: Anthony P. Shuber, William Pierceall
  • Methods for detecting contamination in molecular diagnostics using PCR
    Publication number: 20020025525
    Abstract: The invention provides methods for detecting contamination in a PCR reaction. Methods of the invention are especially useful for detection of contamination in heterogeneous samples containing a rare nucleic acid to be detected.
    Type: Application
    Filed: May 30, 2001
    Publication date: February 28, 2002
    Inventor: Anthony P. Shuber
  • Methods for the detection of loss of heterozygosity
    Publication number: 20020004201
    Abstract: Methods are provided for detecting loss of heterozygosity in a pooled nucleic acid sample obtained from a patient population. These methods are particularly useful for identifying populations or individuals within a population with gene mutations indicative of early colorectal cancer.
    Type: Application
    Filed: December 20, 2000
    Publication date: January 10, 2002
    Inventors: Stanley N. Lapidus, Anthony P. Shuber