Abstract: The present invention relates to pharmaceutical formulations comprising a lipase inhibitor and long-chain fatty acids. The formulation enables the lipase inhibitor to be delivered to the intestinal lymph and are thereby useful in the treatment or prevention of diseases and conditions mediated by pancreatic lipase, such as acute pancreatitis and associated syndromes.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: Monitoring user interaction with a web enabled device (1), which is running a web client (12) for loading and displaying webpages to a user and running a client side module (13) within the web client (12).

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: A cutting element comprises a supporting substrate, and a cutting table attached to the supporting substrate and comprising a substantially planar apex, opposing flat surfaces extending upwardly and inwardly toward the substantially planar apex from locations proximate an interface between the cutting table and the supporting substrate, primary edge surfaces between the substantially planar apex and the opposing flat surfaces and exhibiting one or more of a radiused geometry and a chamfered geometry, opposing semi-conical surfaces intervening between the opposing flat surfaces and extending upwardly and inwardly toward the substantially planar apex from other locations proximate the interface between the cutting table and the supporting substrate, and secondary edge surfaces between the substantially planar apex and the opposing semi-conical surfaces and exhibiting one or more of another radiused geometry and another chamfered geometry.

Abstract: The inventions relate to compositions and articles of manufacture comprising connexin modulators, pannexin modulators, gap junction modulators, hemichannel modulators, and pannexin channel modulators and their use, alone or in combination, in treating ocular and other disorders.

Abstract: An earth-boring tool includes a body, blades extending longitudinally and generally radially from the body, and cutting elements located on each blade. The earth-boring tool may also include a first group of at least two adjacent blades comprising the cutting elements proximate a front cutting edge of the blades and one or more shaped inserts located rotationally following the cutting elements, and a second group of one or more additional blades comprising the cutting elements proximate the front cutting edge of the blades while being entirely free of the one or more shaped inserts. Methods include drilling a subterranean formation including engaging a formation with the cutting elements and the shaped inserts of the earth-boring tool, the shaped inserts secured at selected locations on two or more adjacent blades of the first group of blades while the second group of blades is entirely free of the shaped inserts.

Abstract: A self-adjusting earth-boring tool includes a body carrying cutting elements and an actuation device disposed at least partially within the body. The actuation device may include a first fluid chamber, a second fluid chamber, a first reciprocating member, and a second reciprocating member. The first and second reciprocating members may divide portions of the first fluid chamber from portions of the second fluid chamber. A connection member may be attached to both of the first and second reciprocating members and may have a drilling element removably coupled thereto. A first fluid flow path may extend from the second fluid chamber to the first fluid chamber. A second fluid flow path may extend from the first fluid chamber to the second fluid chamber.

Abstract: An earth-boring tool includes a body, blades extending longitudinally and generally radially from the body, and cutting elements located on each blade. The earth-boring tool may also include a first group of at least two adjacent blades comprising the cutting elements proximate a front cutting edge of the blades and one or more shaped inserts located rotationally following the cutting elements, and a second group of one or more additional blades comprising the cutting elements proximate the front cutting edge of the blades while being entirely free of the one or more shaped inserts. Methods include drilling a subterranean formation including engaging a formation with the cutting elements and the shaped inserts of the earth-boring tool, the shaped inserts secured at selected locations on two or more adjacent blades of the first group of blades while the second group of blades is entirely free of the shaped inserts.

Abstract: A cutting element comprises a supporting substrate, and a cutting table attached to the supporting substrate and comprising a substantially planar apex, opposing flat surfaces extending upwardly and inwardly toward the substantially planar apex from locations proximate an interface between the cutting table and the supporting substrate, primary edge surfaces between the substantially planar apex and the opposing flat surfaces and exhibiting one or more of a radiused geometry and a chamfered geometry, opposing semi-conical surfaces intervening between the opposing flat surfaces and extending upwardly and inwardly toward the substantially planar apex from other locations proximate the interface between the cutting table and the supporting substrate, and secondary edge surfaces between the substantially planar apex and the opposing semi-conical surfaces and exhibiting one or more of another radiused geometry and another chamfered geometry.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract: A self-adjusting earth-boring tool includes a body carrying cutting elements and an actuation device disposed at least partially within the body. The actuation device may include a first fluid chamber, a second fluid chamber, a first reciprocating member, and a second reciprocating member. The first and second reciprocating members may divide portions of the first fluid chamber from portions of the second fluid chamber. A connection member may be attached to both of the first and second reciprocating members and may have a drilling element removably coupled thereto. A first fluid flow path may extend from the second fluid chamber to the first fluid chamber. A second fluid flow path may extend from the first fluid chamber to the second fluid chamber.

Abstract: Connexin protein modulation methods and compositions are provided for the healing of resistant lesions, including lesions on subjects with multiple venous leg ulcers or multiple diabetic foot ulcers, and other responder subjects. Also provided are kits and articles of manufacture comprising a connexin protein modulating agent, for example, a connexin 43 modulating agent for use in the healing of resistant lesions.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract: Methods and compositions for treating neurological damage or dysfunction are described, including methods implemented by administration of peptide inhibitors of AMPA receptor endocytosis.

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.