Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract: A plurality of security events is detected in a computing system, each security event based on at least one policy in a plurality of security policies. Respective interactive graphical representations are presented in a graphical user interface (GUI) of either or both of the security events or security policies. The representations include interactive graphical elements representing the respective security events or security policies. User selection of a particular event element via the interactive GUI causes a subset of the security policies to be identified, each security policy in the subset serving as a basis for at least one particular security event represented by the particular event element. User selection of a particular policy element via the interactive GUI causes a subset of the security policies to be identified, each security event in the subset based at least in part on a particular security policy represented by the particular policy element.

Abstract: A message flow within a message broker can be identified. The message flow can include nodes and connections. The nodes can include a reflective node, a pre-defined node and a user-defined node. The message broker can be an intermediary computer program code able to translate a message from a first formal messaging protocol to a second formal messaging protocol. The code can be stored within a computer readable medium. The reflective node within the message flow can be selected. The reflective node can be associated with an external resource which can be an executable code. The external resource can be executed which can result in the modifying of the structure of the message flow. The modification can occur during runtime. The modification can include node and/or connection adding, altering, and deleting.

Abstract: A message flow within a message broker can be identified. The message flow can include nodes and connections. The nodes can include a reflective node, a pre-defined node and a user-defined node. The message broker can be an intermediary computer program code able to translate a message from a first formal messaging protocol to a second formal messaging protocol. The code can be stored within a computer readable medium. The reflective node within the message flow can be selected. The reflective node can be associated with an external resource which can be an executable code. The external resource can be executed which can result in the modifying of the structure of the message flow. The modification can occur during runtime. The modification can include node and/or connection adding, altering, and deleting.

Abstract: A reaming bit designed to operate with low torque fluctuation when driven with a turbine at speeds in the order of 300-600 RPM and above features a profile that is arcuate from the gauge dimension to the nose area or alternatively has a blunt straight taper section but with a ratio of profile length (PL) to bit size (BS) of under 0.75. The blades extend into a concave cone and the cutting structure continues along the blades towards the center. The blades have a step near the gauge section to increase the exposure of the blade cutting structure. An array of protrusions are disposed parallel to and behind the cutting structure to increase high speed stability and adjacent the blade step transition to protect outer casing on run in.

Abstract: A reaming bit designed to operate with low torque fluctuation when driven with a turbine at speeds in the order of 300-600 RPM and above features a profile that is arcuate from the gauge dimension to the nose area or alternatively has a blunt straight taper section but with a ratio of profile length (PL) to bit size (BS) of under 0.75. The blades extend into a concave cone and the cutting structure continues along the blades towards the center. The blades have a step near the gauge section to increase the exposure of the blade cutting structure. An array of protrusions are disposed parallel to and behind the cutting structure to increase high speed stability and adjacent the blade step transition to protect outer casing on run in.

Abstract: A reaming bit designed to operate with low torque fluctuation when driven with a turbine at speeds in the order of 300-600 RPM and above features a profile that is arcuate from the gauge dimension to the nose area or alternatively has a blunt straight taper section but with a ratio of profile length (PL) to bit size (BS) of under 0.75. The blades extend into a concave cone and the cutting structure continues along the blades towards the center. The blades have a step near the gauge section to increase the exposure of the blade cutting structure. An array of protrusions are disposed parallel to and behind the cutting structure to increase high speed stability and adjacent the blade step transition to protect outer casing on run in.

Abstract: A device for mitigation of temporomandibular joint disorder with lingual tooth surface contact surface, hard palate conformity, anterior pad, and pad wings.

Abstract: A plurality of security events is detected in a computing system, each security event based on at least one policy in a plurality of security policies. Respective interactive graphical representations are presented in a graphical user interface (GUI) of either or both of the security events or security policies. The representations include interactive graphical elements representing the respective security events or security policies. User selection of a particular event element via the interactive GUI causes a subset of the security policies to be identified, each security policy in the subset serving as a basis for at least one particular security event represented by the particular event element. User selection of a particular policy element via the interactive GUI causes a subset of the security policies to be identified, each security event in the subset based at least in part on a particular security policy represented by the particular policy element.

Abstract: A computing system security dashboard is provided for presentation on a computer display device, the dashboard including a plurality of security view panes. Each security view pane, when expanded, presents a respective visualization of security conditions of a particular computing system. When the particular security view pane is collapsed it can hide at least a portion of particular visualizations of security conditions presented using the particular security view pane when expanded. The particular security view pane occupies a smaller area of the dashboard when collapsed than when expanded. A particular visual indicator is presented on the particular security view, at least when collapsed, summarizing at least a portion of the particular security conditions identified in the particular visualizations. A user interaction with the particular collapsed security view pane can prompt the particular security view pane to be expanded in area and present the particular visualizations.

Abstract: One aspect of the invention relates to customized thin-film composite membranes comprising: a porous support; a selective barrier; and one or more polymeric additives dispersed in the porous support in an amount from at least about 1% and about 50% by weight of the porous support. Another aspect of the invention relates to a method of fabricating a porous support comprising the steps of: preparing a polymer solution comprising a polymer, a polymeric additive, and a first liquid; contacting a surface with the polymer solution; and evaporating the liquid. Another aspect of the invention relates to the use of the thin-film composite membranes disclosed herein in osmotically driven membrane processes.

Abstract: A method, system and computer program product for batched remapping of virtual memory addresses for garbage collection in a large object area. A mapping from a table having a first set of virtual memory addresses and sizes of non-contiguous, page-aligned large objects in a large object area to a remapping table having a second set of virtual memory addresses is determined. In a single batch, a request is received that includes the second set of virtual addresses and requests a remapping of the large objects to the second set of virtual memory addresses. The second set of virtual memory addresses is validated, and the large objects are remapped to the second set of virtual memory addresses according to the request. The remapping results in a compaction so that the large objects are contiguous in the large object area. The remapping does not require copying data in physical memory.

Abstract: A method of awarding a prize to a user of an electronic gaming machine (EGM) in a network. The network includes a plurality of venues in which each venue includes at least one EGM. The method includes querying the EGMs to determine changes in win meters of the respective EGMs during a polling cycle. The change in the win meter representative of at least one of a number of wins or an amount won by the corresponding EGM over the cycle. The method also includes deciding to award the prize based on responses to the querying and selecting a winning venue from the network. The method also includes selecting a winning EGM at the winning venue, wherein probabilities of the respective EGMs being selected as the winning EGM are proportional to the changes in the win meters of the respective EGMs at the winning venue over the cycle.

Abstract: A portable charger is provided. The portable charging includes a housing and a power source located in the housing so that that the power source can be inductively recharging through the housing. The portable charger also includes a first output connector coupled to the power source for charging a first electronic device, as well as a second output connector coupled to the power source that is different from the first output connector for charging a second electronic device. The first output connector and the second output connector are configured to be at least partially stored within the housing in order to minimize size of the charger.

Abstract: A method of awarding a prize in a network of electronic gaming machines in which the probability of a machine winning the prize is dependent upon a change in a win meter of the electronic gaming machine within a polling cycle.

Abstract: A message flow within a message broker can be identified. The message flow can include nodes and connections. The nodes can include a reflective node, a pre-defined node and a user-defined node. The message broker can be an intermediary computer program code able to translate a message from a first formal messaging protocol to a second formal messaging protocol. The code can be stored within a computer readable medium. The reflective node within the message flow can be selected. The reflective node can be associated with an external resource which can be an executable code. The external resource can be executed which can result in the modifying of the structure of the message flow. The modification can occur during runtime. The modification can include node and/or connection adding, altering, and deleting.

Abstract: A message flow within a message broker can be identified. The message flow can include nodes and connections. The nodes can include a reflective node, a pre-defined node and a user-defined node. The message broker can be an intermediary computer program code able to translate a message from a first formal messaging protocol to a second formal messaging protocol. The code can be stored within a computer readable medium. The reflective node within the message flow can be selected. The reflective node can be associated with an external resource which can be an executable code. The external resource can be executed which can result in the modifying of the structure of the message flow. The modification can occur during runtime. The modification can include node and/or connection adding, altering, and deleting.

Abstract: The invention provides, in part, methods and reagents for modulating neuronal apoptosis and for modulating synaptic plasticity.

Abstract: A gunstock including a barrel brace and a pistol grip projecting downwardly from the rear of the barrel brace. An X-shaped crosspiece projects rearwardly from the pistol grip. A butt projects rearwardly from the crosspiece. A handle projects forwardly from the bottom of the pistol grip.

Abstract: A gunstock including a barrel brace and a pistol grip projecting downwardly from the rear of the barrel brace. An X-shaped crosspiece projects rearwardly from the pistol grip. A butt projects rearwardly from the crosspiece. A handle projects forwardly from the bottom of the pistol grip.