Abstract: are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.

Abstract: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.

Abstract: A seating indicator for loadbreak connectors and deadbreak connectors that includes a substantially round, elastic O-ring having a body and an opening, wherein the O-ring is installed on the transition shoulder portion of a loadbreak bushing insert, and wherein the O-ring extends radially and outwardly from the bushing insert when an elbow connector is properly installed thereon. The O-ring can be hollow so that it will more easily deform and can be made from an elastomeric material in easily viewable colors.