Abstract: The disclosure provides products configured for oral use, the products including one or more agents adapted to or configured to reduce irritation that may be associated with release of a component from the products. Xylitol in particular may be useful as an irritation reducing agent. The disclosure further provides methods of reducing irritation associated with the release of one or more components from an oral composition or product.

Abstract: The present invention provides compounds of formula I or II: wherein X1, X3, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: The present invention provides compounds of formula I wherein X1, X2, X3, X4, R1, R1a, R1b, R2?, R2?, R3?, R3?, R6 and R7 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

Abstract: The present disclosure provides protein-enriched, tobacco-containing products, suitable for use as oral formulations. Products of the present disclosure typically include at least one tobacco material (e.g., a particulate tobacco material or a tobacco-derived extract), at least one protein-enriched material (e.g., a tobacco-derived protein-enriched material), and at least one sugar alcohol.

Abstract: The disclosure provides products configured for oral use, the products including one or more agents adapted to or configured to reduce irritation that may be associated with release of a component from the products. Xylitol in particular may be useful as an irritation reducing agent. The disclosure further provides methods of reducing irritation associated with the release of one or more components from an oral composition or product.

Abstract: Systems, methods, and computer-readable media are disclosed for filtering data with probabilistic filters for content selection. In one embodiment, an example method may include determining a user interaction history with a first product identifier for a user account, determining a first parent product identifier of the first product identifier, and generating a database with the first parent product identifier and a user account identifier for the user account. Example methods may include determining a set of candidate content with first content and second content for the user account, determining a second product identifier associated with the first content, and determining a second parent product identifier of the second product identifier. Example methods may include determining that the second parent product identifier is not present in the database using a probabilistic filter, and determining that the first content is eligible for presentation.

Abstract: Various embodiments of the present technology may provide methods and apparatus for a time-to-digital converter. The time-to-digital converter may include a state machine that increments/decrements according to an input signal and a count value. The time-to-digital converter may further include a register to store the count value according to the input signal.

Abstract: Aspects described herein relate to receiving a timing adjustment (TA) command indicating to adjust timing for an uplink transmission in a time division, adjusting, by the UE and based on the TA command, the timing for the uplink transmission in the time division, and where the uplink transmission includes an overlapping portion that at least partially overlaps in time with a previous uplink transmission scheduled for transmission in a previous time division, due to the TA command, and a non-overlapping portion that does not at least partially overlap in time with the previous uplink transmission, refraining from transmitting the non-overlapping portion of the uplink transmission that is scheduled in the time division. Other aspects relate to transmitting the TA command and not receiving an overlapping uplink transmission.

Abstract: The present disclosure provides protein-enriched, tobacco-containing products, suitable for use as oral formulations. Products of the present disclosure typically include at least one tobacco material (e.g., a particulate tobacco material or a tobacco-derived extract), at least one protein-enriched material (e.g., a tobacco-derived protein-enriched material), and at least one sugar alcohol.

Abstract: Various embodiments of the present technology may provide methods and apparatus for a time-to-digital converter. The time-to-digital converter may include a state machine that increments/decrements according to an input signal and a count value. The time-to-digital converter may further include a register to store the count value according to the input signal.

Abstract: An air spring includes a first body; a first piston cooperating with the first body to define a pressurized first chamber including a gas, the first piston configured to slideably move relative to the first body; a pressurized second chamber; a flow passage between the first chamber and the second chamber; and a seal to selectively permit or restrict flow between the first chamber and the second chamber depending on a position of the first piston with respect to the first body.

Abstract: Aspects described herein relate to receiving a timing adjustment (TA) command indicating to adjust timing for an uplink transmission in a time division, adjusting, by the UE and based on the TA command, the timing for the uplink transmission in the time division, and where the uplink transmission includes an overlapping portion that at least partially overlaps in time with a previous uplink transmission scheduled for transmission in a previous time division, due to the TA command, and a non-overlapping portion that does not at least partially overlap in time with the previous uplink transmission, refraining from transmitting the non-overlapping portion of the uplink transmission that is scheduled in the time division. Other aspects relate to transmitting the TA command and not receiving an overlapping uplink transmission.

Abstract: A system of using a flow disc to modify a spray pattern of a fuel injector is a system used to change the spray pattern of injected fuel to increase the air to fuel ratio of an engine. The system includes a flow disc and a fuel injector. The flow disc modifies the spray pattern of the injected fuel by the fuel injector to increase the air contact with the injected fuel. The flow disc includes a disc body and a plurality of spray holes. The disc body is designed to securely fit within the fuel injector. The arrangement of the plurality of spray holes helps modify the spray pattern of the injected fuel. The fuel injector includes an injector body and a spray tip. The injector body controls the flow of the fuel being injected into the engine. The spray tip serves as the outlet of the fuel injector.

Abstract: A pouched product including an outer water-permeable pouch defining a cavity and a composition configured for oral use situated within the cavity is provided. The composition is at least partially orally dissolvable, and includes one or more dissolvable fillers in an amount of at least about 45% by weight, based on the total weight of the composition; a humectant in an amount up to about 25% by weight, based on the total weight of the composition; and at least one active ingredient, at least one flavorant, or both at least one active ingredient and at least one flavorant.

Abstract: A computing device is configured to generate a content reference for content displayed on a webpage. An encrypted reference is generated for the content reference. The content is provided, with the content reference, to a client device. A website is provided for the client device upon selection of the content by a user input on the webpage. The website includes an offering and related offerings associated with the content. In accordance with a web action received from the website, a logical table is updated with an entry associated with the encrypted reference. The update may be associated with a credit or a charge based at least in part on the web action for the offering or the related offerings.

Abstract: Isolated O-methylated flavonoid compounds and mixtures of o-methylated flavonoid compounds derived from a plant of the Nicotiana species and methods of obtaining such compounds are provided. The o-methylated flavonoids can be combined with tobacco materials to produce tobacco products (e.g., smoking articles) to enhance the sensory characteristics thereof. The o-methyl flavonoids can alternatively be combined with non-tobacco materials for dietary supplement and/or pharmaceutical use.

Abstract: The disclosure provides for oral compositions that exhibit desired properties associated with moist products while incorporating a relatively low water content. Such compositions may include at least one releasable material, at least one filler/carrier component, and at least one water substitute, such as a polyol. The water substituted may be present in an amount of about 25% by weight or greater based on the total weight of the oral composition, and the compositions and products formed therewith can exhibit a relatively low water activity, such as in the range of about 0.85 or less. The present disclosure further provides methods of forming an oral composition with a mouthfeel corresponding to a moist product while having a relatively low water activity.

Abstract: A composition is provided, the composition including a binder system in an amount of at least about 5% by weight, based on the total weight of the composition, and at least one active ingredient and/or flavoring agent. The binder system includes at least one thermoplastic binding material and at least one plasticizer. The composition is typically substantially free of unbleached tobacco material, excluding any nicotine component present.

Abstract: The disclosure provides products configured for oral use, the products including one or more agents adapted to or configured to reduce irritation that may be associated with release of a component from the products. Xylitol, in particular, may be useful as an irritation reducing agent. The disclosure further provides methods of reducing irritation associated with the release of one or more components from an oral composition or product.

Abstract: The disclosure provides a composition including a filler, a lipid having a melting point of about 29° C. or above, water, and a flavoring agent or an active ingredient or both a flavoring agent and an active ingredient, which is optionally substantially free of isomalt and substantially free of tobacco material, excluding any nicotine component present, based on the total weight of the composition. The disclosure also provides compositions including a filler, a lipid having a melting point of about 29° C. or above, water in an amount of at least about 15% by weight, based on total weight of the composition, and a flavoring agent or an active ingredient or both a flavoring agent and an active ingredient.