Abstract: The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.

Abstract: Features are disclosed for managing routing rules stored by a routing device and used to manage network traffic in a network. A computing device can receive multiple routing rules corresponding to multiple routing devices in the network. The computing device can use a formal specification and a snapshot to generate a model of the network. The computing device may use the model in order to statically determine the set of possible paths without causing the transmission of data between a routing device and a destination. the computing device may compare the identified routing rules and the possible paths in order to determine excess routing rules. The computing device may remove the excess routing rules from the routing rules for each routing device such that each routing device routes subsequent network traffic based on the updated routing rules.

Abstract: Systems and methods detect cortical arousal events from a single time-varying ECG signal that is obtained via single-lead ECG. A pre-trained deep neural network transforms the ECG signal into a sequence of cortical-arousal probabilities. The deep neural network includes an inception module, a residual neural network, and a long short-term memory neural network to identify structure in the ECG signal that distinguishes periods of cortical arousal from periods without cortical arousal.

Abstract: Provided are a tricyclic compound as shown in formula (I) as a CRTH2 inhibitor, or a pharmaceutically acceptable salt, a tautomer, a stereoisomer or a solvate thereof, and the use thereof in treating diseases related to CRTH2 receptors.

Abstract: Disclosed are a cold storage material and a cold storage type cryogenic refrigerator using same. The cold storage material is tin alloy particles, the content of tin in the tin alloy particle is not less than 40% and not more than 99%, and the cold storage material at least includes one component of bismuth, antimony, silver and gold. The cold storage type cryogenic refrigerator includes a cold storage device, and the cold storage material filled in the cold storage device is tin alloy particles, is lead-free, lowly toxic, easy in spherization and extremely accessible and has a relatively good thermal performance, has properties comparable to those of lead, and has a relatively good heat exchange performance when being used in a cold storage type refrigerator.

Abstract: Disclosed are a self-pressure-relief air distribution mechanism and a corresponding cryogenic refrigerator. The self-pressure-relief air distribution mechanism includes an air distribution valve (6) and a rotary valve (7), where a rear face of the air distribution valve (6) is divided into a high-pressure face (66) and a low-pressure face (65), and the high-pressure face (66) and the low-pressure face (65) are hermetically separated by a third sealing ring (b3) that seals the air distribution valve (6) and a cover (2); and the air distribution valve (6) is provided with a pressure-relief hole (61) that axially penetrates an air distribution face (64) and the low-pressure face (65) of the air distribution valve (6), and a low-pressure passage (22) of the cover (2) can communicate with the rear face of the air distribution valve (6) via the pressure-relief hole (61), to guide a low-pressure airflow in the cover (2) to the rear face of the air distribution valve (6).

Abstract: The present disclosure provides a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds. They are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Abstract: An air distribution mechanism and a corresponding cryogenic refrigerator are provided. The air distribution mechanism includes an air distribution valve (6) and a rotary valve (7), the air distribution valve (6) includes an air distribution valve main body (6a) and an air distribution valve seat (6b), an air distribution plane (6a3) that is on the air distribution valve main body (6a) and faces away from the air distribution valve seat (6b) protrudes relative to the air distribution valve seat (6b), the air distribution plane (6a3) is tightly attached to a switching plane (73) on the rotary valve (7), and the switching plane (73) protrudes from the rotary valve (7); the air distribution valve (6) is fixedly mounted in a mounting chamber of a cover (2), and the rotary valve (7) is rotatable around a principal rotation axis O of the rotary valve relative to the air distribution valve (6) to switch connection states of an air distribution side flow path and a switching side flow path.

Abstract: Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleamine 2, 3-dioxygenase 1 (IDO1), potentially useful in the treatment of diseases treatable, such as cancers.

Abstract: The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

Abstract: In some examples, special-purpose machines are provided that facilitate smart copy optimization in a network service or publication system, including software-configured computerized variants of such special-purpose machines and improvements to such variants, and to the technologies by which such special-purpose machines become improved compared to other special-purpose machines that facilitate adding the new features. Such technologies can include special artificial-intelligence (AI), machine-learning (ML), and natural-language-processing (NLP) techniques.

Abstract: An inhibitor of a wild type and Y641F mutant of human histone methyltransferase EZH2 is provided herein. Particularly, the inhibitor is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The inhibitor can be used to treat a cancer or precancerous condition related to EZH2 activity.

Abstract: An inhibitor of a wild type and Y641 F mutant of human histone methyltransferase EZH2 is provided herein. Particularly, the inhibitor is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The inhibitor can be used to treat a cancer or precancerous condition related to EZH2 activity.

Abstract: The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

Abstract: The present disclosure provides systems and methods for determining the presence and severity of sleep disordered breathing in a patient based on the output of a low-cost at-home diagnostic and the results of a health questionnaire. The low-cost at-home diagnostic is a simple photoplethysmographic survey to detect oxygen saturation overnight. Minimum oxygen saturation and other metrics are determined from the photoplethysmographic survey and applied, in combination with the health questionnaire data, to a set of artificial neural networks. Each artificial neural network corresponds to a respective degree of severity of sleep disordered breathing, according to rate of occurrence of apnea and hypopnea events during sleep. Each artificial neural network is trained with a respective subset of clinical data generated from a large population of individuals, to reduce both the false positive and false negative rate of the classifier.

Abstract: Systems, apparatuses, services, platforms, and methods are discussed herein that provide assistance for user interface devices. In one example, an assistance application is provided comprising an imaging system configured to capture an image of a scene, an interface system configured to provide data associated with the image to a distributed assistance service that responsively processes the data to recognize properties of the scene and establish feedback for a user based at least on the properties of the scene, and a user interface configured to provide the feedback to the user.

Abstract: A low-temperature device for separating and purifying gas based on a small-sized low-temperature refrigerating machine includes a primary, secondary and quaternary heat exchanger, at least one small-sized low-temperature refrigerating machine, and at least one liquid collecting tank. The small-sized low-temperature refrigerating machine includes a first cold head and a second cold head, the secondary heat exchanger is provided on the first cold head to form a primary cold head heat exchanger, the quaternary heat exchanger is provided on the second cold head to form a secondary cold head heat exchanger, a mixed gas outlet is connected to an inlet of the primary cold head heat exchanger. By using primary and secondary cold heads of the small-sized low-temperature refrigerating machine as cold sources, gases having different condensing temperature are liquefied and solidified separately, and two or more gases can be separated and purified at a lower cost.

Abstract: A pulse tube refrigerator with an automatic gas flow and phase regulating device is composed by a helium compressor, an air distribution valve, a drive controller, a drive lead, a temperature sensor, a temperature measuring lead, a heat regenerator, a first-stage pulse tube, a second-stage pulse tube, a first-stage air reservoir and a second-stage air reservoir, wherein the air distribution valve is consisted of eight independent valves. According to received temperature signals from the temperature sensors the drive controller transmits order signals to the eight independent valves so as to control the open/close degree, time and sequence of the eight valves of the air distribution valve.

Abstract: A low-temperature device for separating and purifying gas based on a small-sized low-temperature refrigerating machine includes a primary, secondary and quaternary heat exchanger, at least one small-sized low-temperature refrigerating machine, and at least one liquid collecting tank. The small-sized low-temperature refrigerating machine includes a first cold head and a second cold head, the secondary heat exchanger is provided on the first cold head to form a primary cold head heat exchanger, the quaternary heat exchanger is provided on the second cold head to form a secondary cold head heat exchanger, a mixed gas outlet is connected to an inlet of the primary cold head heat exchanger. By using primary and secondary cold heads of the small-sized low-temperature refrigerating machine as cold sources, gases having different condensing temperature are liquefied and solidified separately, and two or more gases can be separated and purified at a lower cost.

Abstract: The invention relates to a pulse tube refrigerator with an automatic gas flow and phase regulating device, comprising a helium compressor (1), an air distribution valve (11), a drive controller (9), a drive lead (10), a temperature sensor, a temperature measuring lead (8), a heat regenerator, a first-stage pulse tube (5), a second-stage pulse tube (6), a first-stage air reservoir (14) and a second-stage air reservoir (15), wherein said air distribution valve (11) comprises eight independent valves of a first valve (21), a second valve (22), a third valve (23), a fourth valve (24), a fifth valve (25), a sixth valve (26), a seventh valve (27) and an eighth valve (28).