Patents by Inventor Arjang Hassibi
Arjang Hassibi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160160271Abstract: This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time.Type: ApplicationFiled: August 10, 2015Publication date: June 9, 2016Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
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Patent number: 9341589Abstract: A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized.Type: GrantFiled: June 20, 2012Date of Patent: May 17, 2016Assignee: Board of Regents, The University of Texas SystemInventors: Arjang Hassibi, Arun Manickam, Rituraj Singh
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Patent number: 9223929Abstract: The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provides methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts.Type: GrantFiled: March 14, 2006Date of Patent: December 29, 2015Assignee: The California Institute of TechnologyInventors: Babak Hassibi, Haris Vikalo, Arjang Hassibi
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Patent number: 9133504Abstract: This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time. The method involves contacting a fluid volume having a plurality of different analytes with a solid substrate having a plurality of different probes. The probes are capable of specifically binding to the analytes. The method also involves measuring signals at multiple time points while the fluid volume is in contact with the substrate. The signals measured at multiple time points can be correlated with the amount of binding of the analytes with the probes. The method eliminates the need to wash the probes before measuring the binding characteristics.Type: GrantFiled: June 5, 2007Date of Patent: September 15, 2015Assignee: California Institute of TechnologyInventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
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Patent number: 9087742Abstract: A high density micro-electrode array includes a transistor layer including a plurality of access transistors and a substrate in operable communication with the transistor layer including, wherein at least a portion of the substrate includes a plurality of trenches. The system includes a plurality of electrodes at least partially located in the plurality of trenches, wherein each of the plurality of electrodes is connected to at least one of the plurality of access transistors and wherein each of the electrodes is separated by a distance less than approximately one microns.Type: GrantFiled: March 13, 2013Date of Patent: July 21, 2015Assignee: International Business Machines CorporationInventors: Kangguo Cheng, Arjang Hassibi, Ali Khakifirooz, Dharmendra S. Modha
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Patent number: 9074942Abstract: A method and apparatus for determining a temperature of a semiconductor device is provided herein. One aspect of the disclosed subject matter is seen in a temperature sensing device. The temperature sensing device comprises a diode and a circuit. The diode is adapted to be reverse biased by a charging voltage applied thereto. The circuit determines a temperature of the diode based on a rate that the voltage on the diode discharges in response to the charging voltage being uncoupled from the diode.Type: GrantFiled: September 10, 2013Date of Patent: July 7, 2015Assignee: Advanced Micro Devices, Inc.Inventors: Golam R. Chowdhury, Arjang Hassibi
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Patent number: 9048141Abstract: A method of aligning a semiconductor chip includes forming a semiconductor chip with a light-activated circuit including at least one photosite, positioning the semiconductor chip relative to a device, and illuminating the positioned semiconductor chip. The method further includes generating an RF signal with an RF circuit based upon illumination of the at least one photosite, and determining the position of the photosite with respect to the device based upon the generated RF signal.Type: GrantFiled: February 28, 2013Date of Patent: June 2, 2015Assignee: Robert Bosch GmbHInventors: Christoph Lang, Arjang Hassibi, Sam Kavusi
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Patent number: 8969781Abstract: An optical biosensor pixel for detecting the amount of light that is generated by the biosensing process and a biosensor array architecture that includes such biosensor pixels. The optical biosensor pixel includes a photodiode configured to convert an incident photon flux into a current. Additionally, the optical biosensor pixel includes an optical filter configured to select specific wavelengths and/or photon flux angles to reach the photodiode from a biological sample. The biosensor pixel further includes a trans-impedance amplifier coupled to the photodiode, where the trans-impedance amplifier is configured to convert the current into a voltage signal. Additionally, the biosensor pixel includes a 1-bit comparator coupled to the trans-impedance amplifier and a 1-bit digital-to-analog converter coupled to the 1-bit comparator, where the 1-bit digital-to-analog converter injects different levels of charge into an input of the trans-impedance amplifier at each cycle based on an output of the 1-bit comparator.Type: GrantFiled: June 28, 2012Date of Patent: March 3, 2015Assignee: Board of Regents, The University of Texas SystemInventors: Arjang Hassibi, Rituraj Singh, Arun Manickam
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Publication number: 20140318958Abstract: A biosensor pixel for measuring current that flows through the electrode surface in response to electrochemical interactions and a biosensor array architecture that includes such biosensor pixels. The biosensor pixel includes an electrode transducer configured to measure a current generated by electrochemical interactions occurring at a recognition layer placed directly on top of it in response to an electrical voltage placed across an electrode transducer-electrolyte interface. The biosensor pixel further includes a trans-impedance amplifier connected to the electrode transducer, where the trans-impedance amplifier is configured to convert the current into a voltage signal as the electrochemical interactions occur.Type: ApplicationFiled: April 30, 2013Publication date: October 30, 2014Applicant: Board of Regents, The University of Texas SystemInventors: Arjang Hassibi, Arun Manickam, Rituraj Singh
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Publication number: 20140242735Abstract: A method of aligning a semiconductor chip includes forming a semiconductor chip with a light-activated circuit including at least one photosite, positioning the semiconductor chip relative to a device, and illuminating the positioned semiconductor chip. The method further includes generating an RF signal with an RF circuit based upon illumination of the at least one photosite, and determining the position of the photosite with respect to the device based upon the generated RF signal.Type: ApplicationFiled: February 28, 2013Publication date: August 28, 2014Applicant: Robert Bosch GmbHInventors: Christoph Lang, Arjang Hassibi, Sam Kavusi
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Patent number: 8637436Abstract: A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.Type: GrantFiled: August 24, 2007Date of Patent: January 28, 2014Assignee: California Institute of TechnologyInventor: Arjang Hassibi
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Publication number: 20140016669Abstract: A method and apparatus for determining a temperature of a semiconductor device is provided herein. One aspect of the disclosed subject matter is seen in a temperature sensing device. The temperature sensing device comprises a diode and a circuit. The diode is adapted to be reverse biased by a charging voltage applied thereto. The circuit determines a temperature of the diode based on a rate that the voltage on the diode discharges in response to the charging voltage being uncoupled from the diode.Type: ApplicationFiled: September 10, 2013Publication date: January 16, 2014Applicant: ADVANCED MICRO DEVICES, INC.Inventors: Golam R. Chowdhury, Arjang Hassibi
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Publication number: 20140011710Abstract: A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized.Type: ApplicationFiled: August 5, 2013Publication date: January 9, 2014Applicant: Board of Regents, The University of Texas SystemInventors: Arjang Hassibi, Arun Manickam, Rituraj Singh
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Publication number: 20140001341Abstract: An optical biosensor pixel for detecting the amount of light that is generated by the biosensing process and a biosensor array architecture that includes such biosensor pixels. The optical biosensor pixel includes a photodiode configured to convert an incident photon flux into a current. Additionally, the optical biosensor pixel includes an optical filter configured to select specific wavelengths and/or photon flux angles to reach the photodiode from a biological sample. The biosensor pixel further includes a trans-impedance amplifier coupled to the photodiode, where the trans-impedance amplifier is configured to convert the current into a voltage signal. Additionally, the biosensor pixel includes a 1-bit comparator coupled to the trans-impedance amplifier and a 1-bit digital-to-analog converter coupled to the 1-bit comparator, where the 1-bit digital-to-analog converter injects different levels of charge into an input of the trans-impedance amplifier at each cycle based on an output of the 1-bit comparator.Type: ApplicationFiled: June 28, 2012Publication date: January 2, 2014Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Arjang Hassibi, Rituraj Singh, Arun Manickam
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Publication number: 20130345065Abstract: A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized.Type: ApplicationFiled: June 20, 2012Publication date: December 26, 2013Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Arjang Hassibi, Arun Manickam, Rituraj Singh
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Patent number: 8573841Abstract: A method and apparatus for determining a temperature of a semiconductor device is provided herein. One aspect of the disclosed subject matter is seen in a temperature sensing device. The temperature sensing device comprises a diode and a circuit. The diode is adapted to be reverse biased by a charging voltage applied thereto. The circuit determines a temperature of the diode based on a rate that the voltage on the diode discharges in response to the charging voltage being uncoupled from the diode.Type: GrantFiled: April 8, 2011Date of Patent: November 5, 2013Assignee: Advanced Micro Devices, Inc.Inventors: Golam R. Chowdhury, Arjang Hassibi
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Publication number: 20130225441Abstract: A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.Type: ApplicationFiled: April 1, 2013Publication date: August 29, 2013Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventor: Arjang Hassibi
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Patent number: 8518329Abstract: A biosensor system incorporating CMOS integrated circuits. In one type of biosensor system, the biosensor system includes a silicon substrate. The biosensor system further includes active devices fabricated on the silicon substrate. Additionally, the biosensor system includes a plurality of metal layers stacked on top of the active devices. Furthermore, the biosensor system includes a passivation layer covering a top metal layer, where the passivation layer includes an opening configured to expose the top metal layer, where the opening is used as a sensing electrode. Additionally, the biosensor system includes a plurality of probes attached to the sensing electrode.Type: GrantFiled: March 12, 2012Date of Patent: August 27, 2013Assignee: Board of Regents, The University of Texas SystemInventors: Arjang Hassibi, Byungchul Jang, Arun Manickam
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Publication number: 20130134546Abstract: A method includes forming one or more trenches in a substrate; lining the one or more trenches with a dielectric liner; filling the one or more trenches with a conductive electrode to form one or more trench electrodes; forming a transistor layer on the substrate; connecting each of the one or more trench electrodes to at least one access transistor in the transistor layer; and thinning the substrate to expose at least a portion of each of the trench electrodes.Type: ApplicationFiled: November 30, 2011Publication date: May 30, 2013Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Kangguo Cheng, Arjang Hassibi, Ali Khakifirooz, Dharmendra S. Modha
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Patent number: 8421521Abstract: Embodiments relate to a metal-oxide-semiconductor device including a metal-oxide-semiconductor field-effect transistor (MOSFET). The MOSFET includes a gate configured to change electrical characteristics based on a sensed chemical characteristic and a source and drain. One of the source and drain is connected to an analysis circuit, and a backgate is connected to an AC voltage source.Type: GrantFiled: June 29, 2012Date of Patent: April 16, 2013Assignee: International Business Machines CorporationInventors: Arjang Hassibi, Bahman Hekmatshoartabari, Ali Khakifirooz, Davood Shahrjerdi