Abstract: An image-guided lumbar puncture aspiration and injector system. The system includes an auto-injection device having a housing, at least one syringe having a fluid, a controller, a processor, a memory, and a display. An imaging device is communicatively coupled to the auto-injection device and captures images of a lumbar puncture area of a patient to be displayed on the display of the auto-injection device, helping identify a location for a lumbar puncture procedure. A needle assembly is coupled to the at least one syringe of the auto-injection device. An outer needle is adapted to be inserted into a location of the lumbar puncture area identified by the imaging device, and an inner needle is adapted to be inserted into the dura of the patient. The outer sheath needle protects the inner needle from contaminants. The controller operates the auto-injection device based on a programmed infusion and aspiration profile.

Abstract: Disclosed are approaches for providing per-application tunnel access, such as virtual private network (VPN) access, in LINUX based systems. In response to an application requesting a network connection, a process identifier of the application and an inode identifier representing a socket for the network connection are obtained. Then, a kernel space map is updated to include the process identifier of the application and the inode identifier. In response to the application making a network connection request, the inode identifier of the application is obtained based at least in part on a source network address, a source port number, a destination network address, and a destination port number. Then, the kernel space map is queried to obtain the process identifier of the application, wherein the inode identifier is a query parameter. Then, a routing policy is identified based at least in part on the process identifier.

Abstract: RNA adsorbed onto lipid nano-emulsion particles and its formulations. The present invention relates, a method of preparing a liquid formulation of RNA complexed with lipid nano-emulsion particles or nano-carriers. It particularly provides a method for preparation of the RNA adsorbed onto lipid nano-emulsion particles in liquid and the formulations of said RNA complexes as such.

Abstract: The technology is generally directed to programming delays in hardware already existing within fiber networks to reduce the unfairness in transmitting and receiving data. The delays may be programmed in the optics hardware after the deployment of the network. The delays may be determined based on the time it takes the networking switch to replicate data to be transmitted and/or the length of the cables. According to some examples, the delays may be programmed at either or both the egress and ingress optics hardware of a cable. The programmable delay reduces the unfairness of one destination, or end user, receiving data before another destination when the information is intended to be received synchronously.

Abstract: A hybrid radiating element may comprise a dielectric substrate having a thickness, a top surface and a bottom surface, and an electrically conductive patch disposed on the top surface of the dielectric substrate. The hybrid radiating element may further comprise a graphene stub disposed on the top surface of the dielectric substrate. The graphene stub may be contiguous with, and electrically coupled to, the electrically conductive patch. The hybrid radiating element may further comprise an electrically conductive layer disposed on the bottom surface of the dielectric substrate. An array of hybrid radiating elements may be arranged in a grid pattern of M rows and N columns. A codebook set of biasing voltages may be arranged to drive the radiating elements in the array as a phase transformation matrix, thereby manipulating the reflection of an incoming electromagnetic wave.

Abstract: Methods, systems, and computer-readable media for orchestration of computations using a remote repository are disclosed. A representation of one or more inputs to a computation is stored in a repository. The computation is assigned to one or more hosts of a plurality of hosts. A representation of program code executable to perform the computation is stored in the repository. A local copy of the one or more inputs is stored on the one or more hosts. The computation is initiated on the one or more hosts using the program code and the local copy of the one or more inputs. The computation is initiated for a plurality of keys. The computation succeeds for one or more keys after the computation has failed for one or more other keys. A representation of one or more outputs of the computation is stored in the repository.

Abstract: Various implementations described herein are directed to a device having memory circuitry having multi-port bitcells, wherein each bitcell of the multi-port bitcells has a read-write port and a read port. The device may have read-write circuitry coupled to the read-write port, wherein the read-write circuitry has write-drive logic and read-sense logic that provide for at least one write and at least one read in a single clock cycle.

Abstract: A method for facilitating charge transfer is provided. The method includes receiving, via an electronic device, a request to transfer charge stored in an energy storage device. The method includes determining a set of parameters of the energy storage device based on the received request. The set of parameters includes an amount of charge determined to be transferred from the energy storage device or a charge level desired to be achieved for the energy storage device. The method includes identifying charging systems available to receive and store charge corresponding to the set of parameters of the energy storage device. The method further includes allocating one of the identified charging systems to receive charge from the energy storage device and store the received amount of charge. The allocated charging system travels to a location of the energy storage device to receive the determined amount of charge from the energy storage device.

Abstract: The present application provides a liposomal composition that multivalently displays a specific glycan ligand, or combination of specific glycan ligands, to specifically target CD33 on microglial cells. Multivalent engagement of CD33 with glycan ligands in the liposomal composition are useful in modulating microglial cell function, particularly as a therapeutic for the preventing, treating or delaying progression of Alzheimer's disease.

Abstract: A classifier detects anomalous activity and models a pattern of life of network entities through a series of machine learning models cooperating with multiple response and training instances, which are served by a scalable cloud platform that receives data associated with processes from multiple endpoint agents. The classifier spins up the multiple response instances to support the detection of anomalous activity through the series of machine learning models and the multiple training instances to support the creation and training of the series of machine learning models modeling of the pattern of life of network entities. The classifier spin ups the multiple response instances and the multiple training instances to automatically scale an amount of response instances and training instances needed to respond to a current data load of the data associated with the processes coming from the endpoint agents connected to the network.

Abstract: The fluid delivery devices, systems and methods described herein include a subcutaneous port, a catheter, and a connection assembly configured to fluidly couple the port and catheter.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: Various implementations described herein are directed to a device having memory circuitry having multi-port bitcells, wherein each bitcell of the multi-port bitcells has a read-write port and a read port. The device may have read-write circuitry coupled to the read-write port, wherein the read-write circuitry has write-drive logic and read-sense logic that provide for at least one write and at least one read in a single clock cycle.

Abstract: Fixation devices are disclosed herein that can be used to secure to a catheter. The fixation devices include a body having a central bore extending therethrough to receive a catheter and at least one end having a tapered profile tapering inwardly a distal edge thereof. The body can include an expanded intermediate portion, such as one or more bulbous portions. The fixation devices can also include suture openings or grooves to secure the devices to tissue.

Abstract: Systems and methods of routing are provided. In the system, one or more processors determine that a packet is to be transmitted to a destination. In one or more aspects of the system, the one or more processors select a next port to be used for transmitting the packet by selecting a set of ports among a plurality of ports based on a static weight configuration associated with each port. The next port may be selected from the set of ports based on a number of hops required to reach the destination from each port and based on an estimated latency from each port to the destination. The one or more processors may then route the packet through the selected next port.

Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient’s natural cerebrospinal fluid (CSF) pulsation or the patient’s heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.

Abstract: Fixation devices are disclosed herein that can be used to secure to a catheter and to tissue. The fixation devices include a body having a bore extending therethrough to receive a catheter. The fixation devices can also include suture openings or grooves to secure the devices to tissue.

Abstract: Methods and devices are disclosed herein that generally provide protection for devices (e.g., microcatheters) having small tips. Methods and devices are also disclosed herein that generally facilitate use of commercially-available stereotactic systems with devices (e.g., microcatheters) having small tips.

Abstract: A system for managing an access to an asset is provided. A digital key to the asset is generated and synchronized between a first user device of a first user and an access control device that controls the access to the asset. A key-sharing request is initiated by the first user device to grant a second user the access to the asset. Based on the key-sharing request, an application server communicates the digital key to a second user device of the second user. When the second user device is within a detection range of the access control device, the access control device receives the digital key from the second user device, validates the digital key, and grants the second user the access to the asset for an access duration defined in the key-sharing request.

Abstract: Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.