Abstract: A classifier detects anomalous activity and models a pattern of life of network entities through a series of machine learning models cooperating with multiple response and training instances, which are served by a scalable cloud platform that receives data associated with processes from multiple endpoint agents. The classifier spins up the multiple response instances to support the detection of anomalous activity through the series of machine learning models and the multiple training instances to support the creation and training of the series of machine learning models modeling of the pattern of life of network entities. The classifier spin ups the multiple response instances and the multiple training instances to automatically scale an amount of response instances and training instances needed to respond to a current data load of the data associated with the processes coming from the endpoint agents connected to the network.

Abstract: A data source is monitored. During the monitoring, an arrival at the data source of each of one or more sets of one or more features is detected. In response to detecting the arrival at the data source of at least a first set of one or more features of the one or more sets of one or more features, data is extracted from the first set of one or more features, data for at least a second set of one or more features of the one or more sets of one or more features is estimated, wherein the second set of one or more features has not yet arrived at the data source, and, based on the extracted data and the estimated data, a data quality metric is predicted.

Abstract: The fluid delivery devices, systems and methods described herein include a subcutaneous port, a catheter, and a connection assembly configured to fluidly couple the port and catheter.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: Various implementations described herein are directed to a device having memory circuitry having multi-port bitcells, wherein each bitcell of the multi-port bitcells has a read-write port and a read port. The device may have read-write circuitry coupled to the read-write port, wherein the read-write circuitry has write-drive logic and read-sense logic that provide for at least one write and at least one read in a single clock cycle.

Abstract: Fixation devices are disclosed herein that can be used to secure to a catheter. The fixation devices include a body having a central bore extending therethrough to receive a catheter and at least one end having a tapered profile tapering inwardly a distal edge thereof. The body can include an expanded intermediate portion, such as one or more bulbous portions. The fixation devices can also include suture openings or grooves to secure the devices to tissue.

Abstract: Systems and methods of routing are provided. In the system, one or more processors determine that a packet is to be transmitted to a destination. In one or more aspects of the system, the one or more processors select a next port to be used for transmitting the packet by selecting a set of ports among a plurality of ports based on a static weight configuration associated with each port. The next port may be selected from the set of ports based on a number of hops required to reach the destination from each port and based on an estimated latency from each port to the destination. The one or more processors may then route the packet through the selected next port.

Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient’s natural cerebrospinal fluid (CSF) pulsation or the patient’s heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.

Abstract: Fixation devices are disclosed herein that can be used to secure to a catheter and to tissue. The fixation devices include a body having a bore extending therethrough to receive a catheter. The fixation devices can also include suture openings or grooves to secure the devices to tissue.

Abstract: Methods and devices are disclosed herein that generally provide protection for devices (e.g., microcatheters) having small tips. Methods and devices are also disclosed herein that generally facilitate use of commercially-available stereotactic systems with devices (e.g., microcatheters) having small tips.

Abstract: A system for managing an access to an asset is provided. A digital key to the asset is generated and synchronized between a first user device of a first user and an access control device that controls the access to the asset. A key-sharing request is initiated by the first user device to grant a second user the access to the asset. Based on the key-sharing request, an application server communicates the digital key to a second user device of the second user. When the second user device is within a detection range of the access control device, the access control device receives the digital key from the second user device, validates the digital key, and grants the second user the access to the asset for an access duration defined in the key-sharing request.

Abstract: Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.

Abstract: A hybrid radiating element may comprise a dielectric substrate having a thickness, a top surface and a bottom surface, and an electrically conductive patch disposed on the top surface of the dielectric substrate. The hybrid radiating element may further comprise a graphene stub disposed on the top surface of the dielectric substrate. The graphene stub may be contiguous with, and electrically coupled to, the electrically conductive patch. The hybrid radiating element may further comprise an electrically conductive layer disposed on the bottom surface of the dielectric substrate. An array of hybrid radiating elements may be arranged in a grid pattern of M rows and N columns. A codebook set of biasing voltages may be arranged to drive the radiating elements in the array as a phase transformation matrix, thereby manipulating the reflection of an incoming electromagnetic wave.

Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: A method for facilitating charge transfer is provided. The method includes receiving, via an electronic device, a request to transfer charge stored in an energy storage device. The method includes determining a set of parameters of the energy storage device based on the received request. The set of parameters includes an amount of charge determined to be transferred from the energy storage device or a charge level desired to be achieved for the energy storage device. The method includes identifying charging systems available to receive and store charge corresponding to the set of parameters of the energy storage device. The method further includes allocating one of the identified charging systems to receive charge from the energy storage device and store the received amount of charge. The allocated charging system travels to a location of the energy storage device to receive the determined amount of charge from the energy storage device.

Abstract: Systems and methods for controlling energy delivered for thermal ablation. An apparatus may include a conductive member comprising an array of conductive filaments, a power supply configured to provide the current to the conductive/resistive member in a plurality of electrical pulses, and a processing circuit coupled to the power supply. The processing circuit is configured to control the supply current value to be greater than or equal to a first current density and less than or equal to a second current density, and control the pulse length to be greater than or equal to a first pulse length and less than a second pulse length, control the supply current value to have a third current density at a first time and a fourth current density at a second time.

Abstract: Aspects of the disclosure are directed to improving academic achievement through predictive analysis. In accordance with one aspect, a method for determining a performance level of college readiness including inputting a number of current students who performed a prepared status; dividing the number of current students by a total number of current students to generate a current year data; subtracting a prior year data from the current year data to generate a difference; sorting the difference in a first category; sorting the current year data in a second category; and determining the performance level based on the first category and the second category.

Abstract: A transdermal permeant delivery system for delivery of at least one permeant into a tissue membrane of a subject comprises a filament array having a plurality of filaments that are disposed in a poration area and configured to deliver thermal energy to the tissue membrane to form a plurality of micropores; a applicator electrically connected to the filament array and configured to supply electrical energy to the filaments in order to create the plurality of micropores in the micropore area; and a patch configured for application on the micropore area and for releaseably containing at least one permeant. Method of treatment comprise using the transdermal permeant delivery system to administered a permeant in the form of a drug to a subject in need thereof.