Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: The disclosed systems and methods are configurable central nervous system (CNS) delivery solutions for therapeutics, such as genetic medicines. The systems and methods first infuse a therapeutic bolus within intrathecal space and subsequently infuse a flush fluid to move the therapeutic bolus rostrally toward a target area and achieve a desired spread in the spine and/or brain. The second location can be at a location caudal to the delivery location of the therapeutic bolus.

Abstract: A method for facilitating charge transfer is provided. The method includes receiving, via an electronic device, a request to transfer charge stored in an energy storage device. The method includes determining a set of parameters of the energy storage device based on the received request. The set of parameters includes an amount of charge determined to be transferred from the energy storage device or a charge level desired to be achieved for the energy storage device. The method includes identifying charging systems available to receive and store charge corresponding to the set of parameters of the energy storage device. The method further includes allocating one of the identified charging systems to receive charge from the energy storage device and store the received amount of charge. The allocated charging system travels to a location of the energy storage device to receive the determined amount of charge from the energy storage device.

Abstract: Systems and methods for controlling energy delivered for thermal ablation. An apparatus may include a conductive member comprising an array of conductive filaments, a power supply configured to provide the current to the conductive/resistive member in a plurality of electrical pulses, and a processing circuit coupled to the power supply. The processing circuit is configured to control the supply current value to be greater than or equal to a first current density and less than or equal to a second current density, and control the pulse length to be greater than or equal to a first pulse length and less than a second pulse length, control the supply current value to have a third current density at a first time and a fourth current density at a second time.

Abstract: Aspects of the disclosure are directed to improving academic achievement through predictive analysis. In accordance with one aspect, a method for determining a performance level of college readiness including inputting a number of current students who performed a prepared status; dividing the number of current students by a total number of current students to generate a current year data; subtracting a prior year data from the current year data to generate a difference; sorting the difference in a first category; sorting the current year data in a second category; and determining the performance level based on the first category and the second category.

Abstract: A transdermal permeant delivery system for delivery of at least one permeant into a tissue membrane of a subject comprises a filament array having a plurality of filaments that are disposed in a poration area and configured to deliver thermal energy to the tissue membrane to form a plurality of micropores; a applicator electrically connected to the filament array and configured to supply electrical energy to the filaments in order to create the plurality of micropores in the micropore area; and a patch configured for application on the micropore area and for releaseably containing at least one permeant. Method of treatment comprise using the transdermal permeant delivery system to administered a permeant in the form of a drug to a subject in need thereof.

Abstract: Fixation devices are disclosed herein that can be used to secure to a catheter and to tissue. The fixation devices include a body having a bore extending therethrough to receive a catheter. The fixation devices can also include suture openings or grooves to secure the devices to tissue.

Abstract: A method for facilitating charging is provided. The method includes receiving a charging request from a user device for charging an energy storage device associated with an acceptor node. The method includes determining a set of charging parameters for the energy storage device based on the charging request. The method includes identifying one or more mobile charging systems that are available within a first geographical region associated with the acceptor node and satisfy the set of charging parameters. The method includes allocating, from the one or more mobile charging systems, a first mobile charging system to charge the energy storage device of the acceptor node. Based on the allocation, the first mobile charging system travels from a first location to reach a second location of the acceptor node to charge the energy storage device.

Abstract: A method for facilitating charging is provided. The method includes receiving a charging request from a user device for charging an energy storage device associated with an acceptor node. The method includes determining a set of charging parameters for the energy storage device based on the charging request. The method includes identifying one or more mobile charging systems that are available within a first geographical region associated with the acceptor node and satisfy the set of charging parameters. The method includes allocating, from the one or more mobile charging systems, a first mobile charging system to charge the energy storage device of the acceptor node. Based on the allocation, the first mobile charging system travels from a first location to reach a second location of the acceptor node to charge the energy storage device.

Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

Abstract: Systems and methods of routing are provided. In the system, one or more processors determine that a packet is to be transmitted to a destination. In one or more aspects of the system, the one or more processors select a next port to be used for transmitting the packet by selecting a set of ports among a plurality of ports based on a static weight configuration associated with each port. The next port may be selected from the set of ports based on a number of hops required to reach the destination from each port and based on an estimated latency from each port to the destination. The one or more processors may then route the packet through the selected next port.

Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.

Abstract: Systems and methods of routing are provided. In the system, one or more processors determine that a packet is to be transmitted to a destination. In one or more aspects of the system, the one or more processors select a next port to be used for transmitting the packet by selecting a set of ports among a plurality of ports based on a static weight configuration associated with each port. The next port may be selected from the set of ports based on a number of hops required to reach the destination from each port and based on an estimated latency from each port to the destination. The one or more processors may then route the packet through the selected next port.

Abstract: Fluid delivery systems and methods of delivering an agent and treating a disorder are disclosed that include a subcutaneously implantable port having a body defining a chamber with an open top and a delivery opening and a septum coupled to the body to extend over the open top of the chamber. The systems and methods can further include an intrathecal catheter having an proximal end configured to be coupled to the port and fluidly coupled to the delivery opening of the chamber and a plug having a body with a passage to receive the intrathecal catheter therethrough. The plug can be configured to be inserted into the fascia to protect against leakage of cerebrospinal fluid.

Abstract: Systems and methods of routing are provided. In the system, one or more processors determine that a packet is to be transmitted to a destination. In one or more aspects of the system, the one or more processors select a next port to be used for transmitting the packet by selecting a set of ports among a plurality of ports based on a static weight configuration associated with each port. The next port may be selected from the set of ports based on a number of hops required to reach the destination from each port and based on an estimated latency from each port to the destination. The one or more processors may then route the packet through the selected next port.

Abstract: Systems and methods for flushing shunt systems are disclosed herein. In some embodiments, a flusher includes a pinch tube that extends over a flush dome such that a user can simultaneously close the pinch tube and actuate the flush dome with a single motion. Flushing and refill valves of the system can be disposed in a cartridge that is laterally-offset from the flush dome, advantageously reducing the height profile of the flusher. Flushers with integrated shunt valves are also disclosed, as are shunt systems with restricted and unrestricted modes for selectively limiting the instances in which a user can open an auxiliary flow path through the system.

Abstract: Fluid delivery systems and methods of delivering an agent and treating a disorder are disclosed that include a subcutaneously implantable port having a body defining a chamber with an open top and a delivery opening and a septum coupled to the body to extend over the open top of the chamber. The systems and methods can further include an intrathecal catheter having an proximal end configured to be coupled to the port and fluidly coupled to the delivery opening of the chamber and a plug having a body with a passage to receive the intrathecal catheter therethrough. The plug can be configured to be inserted into the fascia to protect against leakage of cerebrospinal fluid.

Abstract: The fluid delivery devices, systems and methods described herein include a subcutaneous port, a catheter, and a connection assembly configured to fluidly couple the port and catheter.

Abstract: Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient.